Results 121 to 130 of about 6,100 (143)
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Core-fucosylated glycoproteins as biomarkers for diagnosing pancreatic ductal adenocarcinoma
International Journal of Biological MacromoleculesPancreatic ductal adenocarcinoma (PDAC) is highly malignant, with a five-year survival rate of only 12 %. Exact diagnosis and intervention are critical for improving patient prognosis. Core fucosylation (CF) of proteins plays a vital role in the progression of various cancers, including PDAC.
Xinyu, Zhao +6 more
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Specific increase in serum core-fucosylated haptoglobin in patients with chronic pancreatitis
Pancreatology, 2016Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis of all malignancies, and its diagnosis in early stages is the most important prognostic factor. Chronic pancreatitis (CP), a common background of PDAC occurrence, is morphologically defined as progressive pancreatic fibrosis and inflammation accompanied by pancreatic exocrine cell atrophy.
Makiko Ueda +15 more
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FUT8-mediated core fucosylation stabilizes TMEM67 to promote ciliogenesis
Journal of Cell BiologyGlycosylation of membrane proteins plays an essential role in diverse biological processes. However, it remains unknown whether this posttranslational modification occurs on ciliary membrane proteins. Herein, by mass spectrometry–based proteomic analysis, we demonstrate that multiple membrane proteins localized in the ciliary transition zone undergo ...
Difei Wang +12 more
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Analytical Biochemistry, 1996
Core-fucosylated glycans, derivatized with 2-aminoacridone, consistently migrate slower than the corresponding oligosaccharides which lack this fucose residue, using the micellar electrophoretic capillary chromatography conditions outlined in this study. alpha-Fucosidase digestion of glycans followed by CE analysis has allowed facile differentiation of
G N, Okafo +6 more
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Core-fucosylated glycans, derivatized with 2-aminoacridone, consistently migrate slower than the corresponding oligosaccharides which lack this fucose residue, using the micellar electrophoretic capillary chromatography conditions outlined in this study. alpha-Fucosidase digestion of glycans followed by CE analysis has allowed facile differentiation of
G N, Okafo +6 more
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Site-Specific Analysis of Core and Antenna Fucosylation on Serum Glycoproteins
Analytical ChemistryFucosylation is an important structural feature of glycans and plays an essential role in the regulation of glycoprotein functions. Fucosylation can be classified into core- (CF) and antenna-fucosylation (AF, also known as (sialyl-) Lewis) based on the location on N-glycans, and they perform distinct biological functions.
Jun Li +6 more
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Carbohydrate Research, 1993
Several sialylated and fucosylated oligosaccharides, based upon the N-acetyllactosaminyl core structure, have been synthesized from a single trisaccharide glycoside, beta-D-GlcNAc-(1-->3)-beta-D-Gal-(1-->4)-beta-D-GlcNAc-OCH2(CH2)++ +7CO2CH3, by the sequential use of several glycosyltransferases and one sialidase.
M A, Kashem +3 more
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Several sialylated and fucosylated oligosaccharides, based upon the N-acetyllactosaminyl core structure, have been synthesized from a single trisaccharide glycoside, beta-D-GlcNAc-(1-->3)-beta-D-Gal-(1-->4)-beta-D-GlcNAc-OCH2(CH2)++ +7CO2CH3, by the sequential use of several glycosyltransferases and one sialidase.
M A, Kashem +3 more
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RACK1 inhibits ferroptosis of cervical cancer by enhancing SLC7A11 core-fucosylation
Glycoconjugate JournalReceiver for Activated C Kinase 1 (RACK1) is a highly conserved scaffold protein that can assemble multiple kinases and proteins together to form complexes, thereby regulating signal transduction process and various cellular biological processes, including cell cycle regulation, differentiation, and immune response.
Anqi, Yan, Hao, Wu, Wei, Jiang
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Identification of Core‐Fucosylated Glycoproteins by Single‐Step Truncation of N‐Glycans
Current ProtocolsAbstract Alpha‐1,6 core fucosylation (CF) is a unique glycoform of N‐glycans, and studies showed that CF modifications are involved in the occurrence and progression of various diseases and may provide potential disease biomarkers. Current strategies for the CF glycoproteome are often based on multistep enrichment of glycoproteins or ...
Yao Min, Xinyuan Zhao, Wantao Ying
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