Results 31 to 40 of about 4,042,841 (387)
Journal of Clinical Microbiology, 2021 Burkholderia pseudomallei causes the severe disease melioidosis. Whole-genome sequencing (WGS)-based typing methods currently offer the highest resolution for molecular investigations of this genetically diverse pathogen.
S. Lichtenegger +12 more
semanticscholar +1 more source
BE4max and AncBE4max Are Efficient in Germline Conversion of C:G to T:A Base Pairs in Zebrafish
Cells, 2020 The ease of use and robustness of genome editing by CRISPR/Cas9 has led to successful use of gene knockout zebrafish for disease modeling. However, it still remains a challenge to precisely edit the zebrafish genome to create single-nucleotide ...
Blake Carrington +2 more
doaj +1 more source
Thermal proteome profiling for interrogating protein interactions
Molecular Systems Biology, 2020 Thermal proteome profiling (TPP) is based on the principle that, when subjected to heat, proteins denature and become insoluble. Proteins can change their thermal stability upon interactions with small molecules (such as drugs or metabolites), nucleic ...
André Mateus +7 more
doaj +1 more source
Antibiotics, 2021 Tuberculosis (TB) is an airborne communicable disease with high morbidity and mortality rates, especially in developing countries. The causal agents of TB belong to the complex Mycobacterium tuberculosis (MTBc), which is composed of different human and ...
F. Zakham +3 more
semanticscholar +1 more source
Analysis of the Core Genome and Pan-Genome of Autotrophic Acetogenic Bacteria [PDF]
Frontiers in Microbiology, 2016 Acetogens are obligate anaerobic bacteria capable of reducing carbon dioxide (CO2) to multicarbon compounds coupled to the oxidation of inorganic substrates, such as hydrogen (H2) or carbon monoxide (CO), via the Wood-Ljungdahl pathway. Owing to the metabolic capability of CO2 fixation, much attention has been focused on understanding the unique ...
Shin, Jongoh +3 more
openaire +3 more sources
5’isomiR-183-5p|+2 elicits tumor suppressor activity in a negative feedback loop with E2F1
Journal of Experimental & Clinical Cancer Research, 2022 Background MicroRNAs (miRNAs) and isomiRs play important roles in tumorigenesis as essential regulators of gene expression. 5’isomiRs exhibit a shifted seed sequence compared to the canonical miRNA, resulting in different target spectra and thereby ...
Xiaoya Li +19 more
doaj +1 more source
Neutral genomic microevolution of a recently emerged pathogen, salmonella enterica serovar agona [PDF]
, 2013 Salmonella enterica serovar Agona has caused multiple food-borne outbreaks of gastroenteritis since it was first isolated in 1952. We analyzed the genomes of 73 isolates from global sources, comparing five distinct outbreaks with sporadic infections as
Achtman, Mark +9 more
core +3 more sources
Expansion of CORE-SINEs in the genome of the Tasmanian devil [PDF]
, 2012 Background: The genome of the carnivorous marsupial, the Tasmanian devil (Sarcophilus harrisii, Order: Dasyuromorphia), was sequenced in the hopes of finding a cure for or gaining a better understanding of the contagious devil facial tumor disease that ...
Hallström, Björn M. +4 more
core +2 more sources
Genome Biology, 2014 Whole-genome sequences are now available for many microbial species and clades, however existing whole-genome alignment methods are limited in their ability to perform sequence comparisons of multiple sequences simultaneously. Here we present the Harvest
Todd J. Treangen +3 more
semanticscholar +1 more source
Streptococcus thermophilus Core Genome: Comparative Genome Hybridization Study of 47 Strains [PDF]
Applied and Environmental Microbiology, 2008 ABSTRACT A DNA microarray platform based on 2,200 genes from publicly available sequences was designed for Streptococcus thermophilus . We determined how single-nucleotide polymorphisms in the 65- to 75-mer oligonucleotide probe sequences affect the hybridization signals. The microarrays were then used for
Thomas Bovbjerg, Rasmussen +5 more
openaire +2 more sources