Results 31 to 40 of about 3,479,520 (326)

Development and Validation of a Burkholderia pseudomallei Core Genome Multilocus Sequence Typing Scheme To Facilitate Molecular Surveillance

Journal of Clinical Microbiology, 2021
Burkholderia pseudomallei causes the severe disease melioidosis. Whole-genome sequencing (WGS)-based typing methods currently offer the highest resolution for molecular investigations of this genetically diverse pathogen.
S. Lichtenegger, T. T. Trinh, K. Assig, K. Prior, D. Harmsen, Julian Pesl, A. Zauner, M. Lipp, T. A. Que, Beatrice Mutsam, B. Kleinhappl, I. Steinmetz, G. Wagner   +12 more
semanticscholar   +1 more source

5’isomiR-183-5p|+2 elicits tumor suppressor activity in a negative feedback loop with E2F1

Journal of Experimental & Clinical Cancer Research, 2022
Background MicroRNAs (miRNAs) and isomiRs play important roles in tumorigenesis as essential regulators of gene expression. 5’isomiRs exhibit a shifted seed sequence compared to the canonical miRNA, resulting in different target spectra and thereby ...
Xiaoya Li, Birgitta Elisabeth Michels, Oyku Ece Tosun, Janine Jung, Jolane Kappes, Susanne Ibing, Nishanth Belugali Nataraj, Shashwat Sahay, Martin Schneider, Angelika Wörner, Corinna Becki, Naveed Ishaque, Lars Feuerbach, Bernd Heßling, Dominic Helm, Rainer Will, Yosef Yarden, Karin Müller-Decker, Stefan Wiemann, Cindy Körner   +19 more
doaj   +1 more source

Pan and Core Genome Analysis of 183 Mycobacterium tuberculosis Strains Revealed a High Inter-Species Diversity among the Human Adapted Strains

Antibiotics, 2021
Tuberculosis (TB) is an airborne communicable disease with high morbidity and mortality rates, especially in developing countries. The causal agents of TB belong to the complex Mycobacterium tuberculosis (MTBc), which is composed of different human and ...
F. Zakham, T. Sironen, O. Vapalahti, R. Kant   +3 more
semanticscholar   +1 more source

Expansion of CORE-SINEs in the genome of the Tasmanian devil [PDF]

BMC Genomics, 2012
AbstractBackgroundThe genome of the carnivorous marsupial, the Tasmanian devil (Sarcophilus harrisii, Order: Dasyuromorphia), was sequenced in the hopes of finding a cure for or gaining a better understanding of the contagious devil facial tumor disease that is threatening the species’ survival.
Nilsson, Maria Anna, Janke, Axel, Murchison, Elizabeth P., Ning, Zemin, Hallström, Björn M.   +4 more
openaire   +6 more sources

HierCC: a multi-level clustering scheme for population assignments based on core genome MLST

bioRxiv, 2020
Motivation Routine infectious disease surveillance is increasingly based on large-scale whole genome sequencing databases. Real-time surveillance would benefit from immediate assignments of each genome assembly to hierarchical population structures. Here
Zhemin Zhou, J. Charlesworth, M. Achtman
semanticscholar   +1 more source

Genome wide analysis of Arabidopsis core promoters [PDF]

BMC Genomics, 2005
Abstract Background Core promoters are the gene regulatory regions most proximal to the transcription start site (TSS), central to the formation of pre-initiation complexes and for combinatorial gene regulation. The DNA elements required for core promoter function in plants are poorly understood.
Erich Grotewold, Carlos Molina, Carlos Molina   +2 more
openaire   +4 more sources

A robust pipeline for efficient knock-in of point mutations and epitope tags in zebrafish using fluorescent PCR based screening

BMC Genomics, 2022
Background Genome editing using CRISPR/Cas9 has become a powerful tool in zebrafish to generate targeted gene knockouts models. However, its use for targeted knock-in remains challenging due to inefficient homology directed repair (HDR) pathway in ...
Blake Carrington, Ramanagouda Ramanagoudr-Bhojappa, Erica Bresciani, Tae-Un Han, Raman Sood   +4 more
doaj   +1 more source

Haplotyping the Vitis collinear core genome with rhAmpSeq improves marker transferability in a diverse genus

Nature Communications, 2020
Transferable DNA markers are essential for breeding and genetics. Grapevine (Vitis) breeders utilize disease resistance alleles from congeneric species ~20 million years divergent, but existing Vitis marker platforms have cross-species transfer rates as ...
C. Zou, Avinash Karn, B. Reisch, A. Nguyen, Yongming Sun, Yun Bao, Michael Campbell, D. Church, Stephen Williams, Xia Xu, C. Ledbetter, Sagar Patel, A. Fennell, J. Glaubitz, M. Clark, D. Ware, J. Londo, Qi Sun, L. Cadle-Davidson   +18 more
semanticscholar   +1 more source

Tracy: basecalling, alignment, assembly and deconvolution of sanger chromatogram trace files

BMC Genomics, 2020
Background DNA sequencing is at the core of many molecular biology laboratories. Despite its long history, there is a lack of user-friendly Sanger sequencing data analysis tools that can be run interactively as a web application or at large-scale in ...
Tobias Rausch, Markus Hsi-Yang Fritz, Andreas Untergasser, Vladimir Benes   +3 more
doaj   +1 more source

Comparative genomics of Drosophila and human core promoters [PDF]

Genome Biology, 2006
Abstract Background The core promoter region plays a critical role in the regulation of eukaryotic gene expression. We have determined the non-random distribution of DNA sequences relative to the transcriptional start site in Drosophila melanogaster promoters to identify sequences that may be biologically
Brian Oliver, Peter C. FitzGerald, Charles Vinson, David Sturgill, Andrey Shyakhtenko   +4 more
openaire   +3 more sources