Results 21 to 30 of about 558,921 (264)
Core resources for genome analysis
, 2021 The Wellcome Sanger Institute will sequence and assemble tens of thousands of genomes across the next decade through large-scale biodiversity sequencing projects such as Darwin Tree of Life. The projects span the entire tree of eukaryotic life, and the genomes will enable new and unprecedented science.
Muffato, Matthieu, Blaxter, Mark
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Expansion of CORE-SINEs in the genome of the Tasmanian devil [PDF]
BMC Genomics, 2012 AbstractBackgroundThe genome of the carnivorous marsupial, the Tasmanian devil (Sarcophilus harrisii, Order: Dasyuromorphia), was sequenced in the hopes of finding a cure for or gaining a better understanding of the contagious devil facial tumor disease that is threatening the species’ survival.
Nilsson, Maria Anna +4 more
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Tracy: basecalling, alignment, assembly and deconvolution of sanger chromatogram trace files
BMC Genomics, 2020 Background DNA sequencing is at the core of many molecular biology laboratories. Despite its long history, there is a lack of user-friendly Sanger sequencing data analysis tools that can be run interactively as a web application or at large-scale in ...
Tobias Rausch +3 more
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BMC Genomics, 2022 Background Genome editing using CRISPR/Cas9 has become a powerful tool in zebrafish to generate targeted gene knockouts models. However, its use for targeted knock-in remains challenging due to inefficient homology directed repair (HDR) pathway in ...
Blake Carrington +4 more
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Current Research in Toxicology, 2021 Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that, upon activation by ligands, heterodimerizes with retinoid X receptor (RXR), binds to PPAR response elements (PPREs), and activates transcription of downstream genes.
Vanessa Cheng +5 more
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Fast Evolution of Core Promoters in Primate Genomes [PDF]
Molecular Biology and Evolution, 2008 Despite much interest in regulatory evolution, how promoters have evolved remains poorly studied, mainly owing to paucity of data on promoter regions. Using a new set of high-quality experimentally determined core promoters of the human genome, we conducted a comparative analysis of 2,492 human and rhesus macaque promoters and their neighboring nearly ...
Han, Liang +2 more
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Super enhancers—Functional cores under the 3D genome [PDF]
Cell Proliferation, 2020 AbstractComplex biochemical reactions take place in the nucleus all the time. Transcription machines must follow the rules. The chromatin state, especially the three‐dimensional structure of the genome, plays an important role in gene regulation and expression.
Juqing Zhang +5 more
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mOTUpan: a robust Bayesian approach to leverage metagenome assembled genomes for core-genome estimation [PDF]
NAR Genomics and Bioinformatics, 2021 Abstract Recent advances in sequencing and bioinformatics have expanded the tree of life by providing genomes for uncultured environmentally relevant clades, either through metagenome assembled genomes (MAGs) or single-cell assembled genomes (SAGs).
Moritz Buck +2 more
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Thermal proteome profiling in bacteria: probing protein state in vivo
Molecular Systems Biology, 2018 Increasing antibiotic resistance urges for new technologies for studying microbes and antimicrobial mechanism of action. We adapted thermal proteome profiling (TPP) to probe the thermostability of Escherichia coli proteins in vivo. E.
André Mateus +7 more
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Microbiology Spectrum, 2022 Staphylococcus aureus is a Gram-positive pathogen that causes various infections in humans and domestic animals. In China, S. aureus is the most common Gram-positive pathogen that causes clinical infections.
Zhen Xu, Chao Yuan
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