Results 81 to 90 of about 3,231,062 (301)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Low-loss Multimoded Antiresonant Hollow Core Fiber

14th Pacific Rim Conference on Lasers and Electro-Optics (CLEO PR 2020), 2020
We report the first design for low-loss, multimoded antiresonant hollow-core fiber for applications requiring multiple modes. The designed fiber guides 6 - 9 spatially distinct core modes having confinement loss <0.001 - 0.01dB/m respectively.
Goel, Charu, Yoo, Seongwoo
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Magnetization-Dependent Core-Loss Model in a Three-Phase Self-Excited Induction Generator

Energies, 2018
Steady-state, transient, as well as dynamic analyses of self-excited induction generators (SEIGs) are generally well-documented. However, in most of the documented studies, core losses have been neglected or inaccurately modeled.
Saleh H. Al-Senaidi, Abdulrahman I. Alolah, Majeed A. Alkanhal   +2 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Core Structure and Electromagnetic Field Evaluation in WPT Systems for Charging Electric Vehicles

Energies, 2018
The electromagnetic field (EMF) in a wireless power transfer (WPT) system needs to couple inductively between the primary and the secondary coils through a large air gap, thus giving the system a loosely coupled characteristic.
Kamal Eldin Idris Elnail, Xueliang Huang, Chen Xiao, Linlin Tan, Xu Haozhe   +4 more
doaj   +1 more source

Physical Modeling of Core Losses in Ferrite E-Cores

IEEE Open Journal of Power Electronics
The development of advanced power electronic converters requires an accurate calculation of core losses in magnetic devices. But the losses in the widely used ferrite cores depend on the shape of the core, especially above 100kHz, meaning that core losses can not be estimated by simply scaling reference data with respect to the volume of the core.
Théophane Dimier, Jürgen Biela
openaire   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

High-Frequency Gap Losses in Nanocrystalline Cores

IEEE Transactions on Power Electronics, 2017
Finite element analysis is used to examine the gap losses that occur in finely laminated nanocrystalline inductor cores under high-frequency operation. The losses are seen to be concentrated in the region of the air gap and the dependence of the losses on key design parameters and operating conditions is explored.
Wang, Yiren, Calderon-Lopez, Gerardo, Forsyth, Andrew   +2 more
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source