Results 1 to 10 of about 683,682 (149)

Targeting CD70 in combination with chemotherapy to enhance the anti-tumor immune effects in non-small cell lung cancer

OncoImmunology, 2023
Despite the recent emergence of immune checkpoint inhibitors, clinical outcomes of metastatic NSCLC patients remain poor, pointing out the unmet need to develop novel therapies to enhance the anti-tumor immune response in NSCLC.
Tal Flieswasser, Astrid Van den Eynde, Laurie Freire Boullosa, Jöran Melis, Christophe Hermans, Céline Merlin, Ho Wa Lau, Jonas Van Audenaerde, Filip Lardon, Evelien Smits, Patrick Pauwels, Julie Jacobs   +11 more
doaj   +1 more source

The CD70-CD27 axis in oncology: the new kids on the block

Journal of Experimental & Clinical Cancer Research, 2022
The immune checkpoint molecule CD70 and its receptor CD27 are aberrantly expressed in many hematological and solid malignancies. Dysregulation of the CD70-CD27 axis within the tumor and its microenvironment is associated with tumor progression and ...
Tal Flieswasser, Astrid Van den Eynde, Jonas Van Audenaerde, Jorrit De Waele, Filip Lardon, Carsten Riether, Hans de Haard, Evelien Smits, Patrick Pauwels, Julie Jacobs   +9 more
doaj   +1 more source

Single-organoid analysis reveals clinically relevant treatment-resistant and invasive subclones in pancreatic cancer

npj Precision Oncology, 2023
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal diseases, characterized by a treatment-resistant and invasive nature. In line with these inherent aggressive characteristics, only a subset of patients shows a clinical response to the ...
Maxim Le Compte, Edgar Cardenas De La Hoz, Sofía Peeters, Felicia Rodrigues Fortes, Christophe Hermans, Andreas Domen, Evelien Smits, Filip Lardon, Timon Vandamme, Abraham Lin, Steve Vanlanduit, Geert Roeyen, Steven Van Laere, Hans Prenen, Marc Peeters, Christophe Deben   +15 more
doaj   +1 more source

Core–periphery structure in directed networks [PDF]

Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2020
Empirical networks often exhibit different meso-scale structures, such as community and core–periphery structures. Core–periphery structure typically consists of a well-connected core and a periphery that is well connected to the core but sparsely connected internally. Most core–periphery studies focus on undirected networks.
Elliott, A, Chiu, A, Bazzi, M, Reinert, G, Cucuringu, M   +4 more
openaire   +5 more sources

Auranofin and Cold Atmospheric Plasma Synergize to Trigger Distinct Cell Death Mechanisms and Immunogenic Responses in Glioblastoma

Cells, 2021
Targeting the redox balance of malignant cells via the delivery of high oxidative stress unlocks a potential therapeutic strategy against glioblastoma (GBM).
Jinthe Van Loenhout, Laurie Freire Boullosa, Delphine Quatannens, Jorrit De Waele, Céline Merlin, Hilde Lambrechts, Ho Wa Lau, Christophe Hermans, Abraham Lin, Filip Lardon, Marc Peeters, Annemie Bogaerts, Evelien Smits, Christophe Deben   +13 more
doaj   +1 more source

Core Percolation on Complex Networks [PDF]

Physical Review Letters, 2012
As a fundamental structural transition in complex networks, core percolation is related to a wide range of important problems. Yet, previous theoretical studies of core percolation have been focusing on the classical Erd s-R nyi random networks with Poisson degree distribution, which are quite unlike many real-world networks with scale-free or fat ...
Yang-Yu, Liu, Endre, Csóka, Haijun, Zhou, Márton, Pósfai   +3 more
openaire   +4 more sources

A systematic review on poly(I:C) and poly-ICLC in glioblastoma: adjuvants coordinating the unlocking of immunotherapy

Journal of Experimental & Clinical Cancer Research, 2021
Immunotherapy is currently under intensive investigation as a potential breakthrough treatment option for glioblastoma. Given the anatomical and immunological complexities surrounding glioblastoma, lymphocytes that infiltrate the brain to develop durable
Jorrit De Waele, Tias Verhezen, Sanne van der Heijden, Zwi N. Berneman, Marc Peeters, Filip Lardon, An Wouters, Evelien L. J. M. Smits   +7 more
doaj   +1 more source

The prognostic impact of the immune signature in head and neck squamous cell carcinoma

Frontiers in Immunology, 2022
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumors that retain their poor prognosis despite recent advances in their standard of care.
Hasan Baysal, Vasiliki Siozopoulou, Vasiliki Siozopoulou, Hannah Zaryouh, Christophe Hermans, Ho Wa Lau, Hilde Lambrechts, Erik Fransen, Ines De Pauw, Julie Jacobs, Marc Peeters, Marc Peeters, Patrick Pauwels, Patrick Pauwels, Jan Baptist Vermorken, Jan Baptist Vermorken, Evelien Smits, Evelien Smits, Filip Lardon, Jorrit De Waele, An Wouters   +20 more
doaj   +1 more source

Cellular senescence in cancer: clinical detection and prognostic implications

Journal of Experimental & Clinical Cancer Research, 2022
Cellular senescence is a state of stable cell-cycle arrest with secretory features in response to cellular stress. Historically, it has been considered as an endogenous evolutionary homeostatic mechanism to eliminate damaged cells, including damaged ...
Andreas Domen, Christophe Deben, Jasper Verswyvel, Tal Flieswasser, Hans Prenen, Marc Peeters, Filip Lardon, An Wouters   +7 more
doaj   +1 more source

The Role of Akt in Acquired Cetuximab Resistant Head and Neck Squamous Cell Carcinoma: An In Vitro Study on a Novel Combination Strategy

Frontiers in Oncology, 2021
The epidermal growth factor receptor (EGFR) is a therapeutic target in head and neck squamous cell carcinoma (HNSCC). Resistance to EGFR-targeted therapies, such as cetuximab, poses a challenging problem.
Hannah Zaryouh, Ines De Pauw, Hasan Baysal, Patrick Pauwels, Patrick Pauwels, Marc Peeters, Marc Peeters, Jan Baptist Vermorken, Jan Baptist Vermorken, Filip Lardon, An Wouters   +10 more
doaj   +1 more source