Results 31 to 40 of about 726,031 (169)

Optimising Satellite and Core Networks for a Global Quantum Network

Journal of Optical Communications and Networking, 2023
Quantum Key Distribution (QKD) promises information theoretic security. However, the exponential decay of the secure key in optical fibres leads to limitations in long distance QKD distribution across fibres, which is necessary for global Quantum Networks (QNs).
Vasileios Karavias, Catherine White, Andrew Lord, Michael Christopher Payne   +3 more
openaire   +1 more source

Precision of image-guided spinal stereotactic ablative radiotherapy and impact of positioning variables

Physics and Imaging in Radiation Oncology, 2022
Background and purpose: Spinal stereotactic ablative body radiotherapy (SABR) requires high precision. We evaluate the intrafraction motion during cone-beam computed tomography (CBCT) guided SABR with different immobilization techniques.
Charlotte Billiet, Wim Vingerhoed, Steven Van Laere, Ines Joye, Carole Mercier, Piet Dirix, Daan Nevens, Peter Vermeulen, Paul Meijnders, Dirk Verellen   +9 more
doaj   +1 more source

Structure and dynamics of core/periphery networks [PDF]

Journal of Complex Networks, 2013
Recent studies uncovered important core/periphery network structures characterizing complex sets of cooperative and competitive interactions between network nodes, be they proteins, cells, species or humans. Better characterization of the structure, dynamics and function of core/periphery networks is a key step of our understanding cellular functions ...
Csermely Péter, London András, Wu Ling-Yun, Uzzi Brian   +3 more
openaire   +4 more sources

ON THE CORE OF THE NETWORK DESIGN GAME

Journal of the Operations Research Society of Japan, 1992
Summary: We consider a cooperative game on a communication network system whose objective is to find a fair allocation of the total cost for constructing the network among customers. Since an NP-hard combinatorial optimization problem must be solved for calculating the exact network design cost, we consider a game in which lower bounds obtained by ...
Kubo, Mikio, Kasugai, Hiroshi
openaire   +3 more sources

The Multistationarity Structure of Networks with Intermediates and a Binomial Core Network [PDF]

Bulletin of Mathematical Biology, 2019
This work addresses whether a reaction network, taken with mass-action kinetics, is multistationary, that is, admits more than one positive steady state in some stoichiometric compatibility class. We build on previous work on the effect that removing or adding intermediates has on multistationarity, and also on methods to detect multistationarity for ...
AmirHosein Sadeghimanesh, Elisenda Feliu
openaire   +6 more sources

Auranofin repurposing for lung and pancreatic cancer: low CA12 expression as a marker of sensitivity in patient-derived organoids, with potentiated efficacy by AKT inhibition

Journal of Experimental & Clinical Cancer Research
Background This study explores the repurposing of Auranofin (AF), an anti-rheumatic drug, for treating non-small cell lung cancer (NSCLC) adenocarcinoma and pancreatic ductal adenocarcinoma (PDAC). Drug repurposing in oncology offers a cost-effective and
Christophe Deben, Laurie Freire Boullosa, Felicia Rodrigues Fortes, Edgar Cardenas De La Hoz, Maxim Le Compte, Sofie Seghers, Marc Peeters, Steve Vanlanduit, Abraham Lin, Krijn K. Dijkstra, Paul Van Schil, Jeroen M. H. Hendriks, Hans Prenen, Geert Roeyen, Filip Lardon, Evelien Smits   +15 more
doaj   +1 more source

Co-targeting of VEGFR2 and PD-L1 promotes survival and vasculature normalization in pleural mesothelioma

OncoImmunology
Pleural mesothelioma (PM) is an aggressive cancer caused by asbestos exposure, with limited treatment options and poor prognosis, highlighting the need for more effective therapies.
Sophie Rovers, Jonas Van Audenaerde, Ruben Verloy, Jorrit De Waele, Louize Brants, Christophe Hermans, Ho Wa Lau, Céline Merlin, Maria Möller Ribas, Peter Ponsaerts, Steven Van Laere, Filip Lardon, An Wouters, Scott A. Fisher, Jan van Meerbeeck, Elly Marcq, Evelien Smits   +16 more
doaj   +1 more source

Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell lung cancer

Redox Biology, 2021
Auranofin (AF) is an FDA-approved antirheumatic drug with anticancer properties that acts as a thioredoxin reductase 1 (TrxR) inhibitor. The exact mechanisms through which AF targets cancer cells remain elusive.
Laurie Freire Boullosa, Jinthe Van Loenhout, Tal Flieswasser, Jorrit De Waele, Christophe Hermans, Hilde Lambrechts, Bart Cuypers, Kris Laukens, Esther Bartholomeus, Vasiliki Siozopoulou, Winnok H. De Vos, Marc Peeters, Evelien L.J. Smits, Christophe Deben   +13 more
doaj   +1 more source

Evolution Characteristics of the Network Core in the Facebook [PDF]

PLoS ONE, 2014
Statistical properties of the static networks have been extensively studied. However, online social networks are evolving dynamically, understanding the evolving characteristics of the core is one of major concerns in online social networks. In this paper, we empirically investigate the evolving characteristics of the Facebook core.
Liu, Jian-Guo, Ren, Zhuo-Ming, Guo, Qiang, Chen, Duan-Bing   +3 more
openaire   +4 more sources

Protein-level profiling of TIGIT axis components in human PDAC reveals immune–suppressive expression patterns

Cancer Immunology, Immunotherapy
Purpose In pancreatic ductal adenocarcinoma (PDAC), immune checkpoint inhibitors have shown limited efficacy, and the role of the TIGIT axis remains underexplored.
D. Quatannens, Y. Verhoeven, S. van der Heijden, D. Peeters, J. Claes, C. Hermans, H. Lambrechts, K. Zwaenepoel, P. van Dam, M. Peeters, H. Prenen, S. Koljenovic, J. De Waele, C. Faes, F. Lardon, G. Roeyen, E. Smits, J. Van Audenaerde   +17 more
doaj   +1 more source