Results 1 to 10 of about 5,328 (197)

Synthesis and in vitro characterization of [198Au]Auranofin [PDF]

EJNMMI Radiopharmacy and Chemistry
Background Radiopharmaceuticals offer targeted treatment by combining diagnostic or therapeutic radionuclides with biologically active molecules. Auranofin is the only Food and Drug Administration (FDA) approved gold(I) complex, originally developed for ...
Punita Bhardwaj, Caroline Frohner, Christopher Geppert, Christian Gorges, Winfried Brenner, Guilhem Claude, Sarah Spreckelmeyer   +6 more
doaj   +3 more sources

Reactive oxygen species promotion drives auranofin’s antiviral activity against hepatitis E virus [PDF]

Journal of Virology
Hepatitis E virus (HEV) causes roughly 20 million yearly global infections and is associated with chronic hepatitis, neurological sequelae, and pregnancy-related adverse outcomes that require antiviral intervention.
Kateland Tiller, S. Tyler Williams, Bo Wang, Debin Tian, Xiang-Jin Meng, James Weger-Lucarelli   +5 more
doaj   +2 more sources

Structural basis of ligand selectivity in FAD/NAD(P)H-dependent dehydrogenases: insights from trypanothione reductase and type II NADH dehydrogenase. [PDF]

Protein Sci
Abstract FAD/NAD(P)H‐dependent dehydrogenases form a structurally conserved family of redox enzymes that participate in essential metabolic processes across parasites and higher organisms. Among them, trypanothione reductase (TR) is a key component of the redox metabolism of Leishmania species and represents an attractive target for antileishmanial ...
Perrone GCM, Spadone S, Francavilla AL, Morselli S, Todisco S, Ortalli M, Mendoza-Roldan JA, Scaglione V, Sgobba MN, Guerra L, Belluti F, Varani S, Otranto D, De Grassi A, Volpicella M, Pierri CL.   +15 more
europepmc   +2 more sources

Auranofin Ameliorates Gouty Inflammation by Suppressing NLRP3 Activation and Neutrophil Migration via the IL-33/ST2–CXCL1 Axis [PDF]

Cells
Gout is a form of sterile inflammatory arthritis in which monosodium urate (MSU) crystals deposit and provoke a neutrophil-predominant response, primarily driven by activation of the NACHT, leucine-rich repeat, and pyrin domain-containing protein 3 ...
Hyeyeon Yoo, Ahyoung Choi, Minjun Kim, Yongseok Gye, Hyeonju Jo, Seung-Ki Kwok, Youngjae Park, Jennifer Jooha Lee   +7 more
doaj   +2 more sources

Auranofin Combination Therapy: A New Frontier in Cancer Treatment [PDF]

Molecules
Auranofin, a gold(I)-based compound initially developed for the treatment of rheumatoid arthritis, has emerged as a promising anticancer agent with a multimodal mechanism of action.
Diana Laura Guzman-Gomez, Srinivasa Reddy Telukutla, Ruchika Ojha, Suresh K. Bhargava, Magdalena Plebanski   +4 more
doaj   +2 more sources

Auranofin potentiates linezolid activity against MRSA by disrupting redox homeostasis and inhibiting SarA-mediated virulence and biofilm [PDF]

Virulence
Methicillin-resistant Staphylococcus aureus (MRSA) remains a major therapeutic challenge and poses a significant global health threat. Developing adjuvants to enhance the efficacy of existing antibiotics represents a promising strategy to address this ...
Jian-Guo Li, Wei-Cheng Zhong, Long-Gen Zhong, Chao-Yan Niu, Ting-Yin Lu, Chuan-Jian Zhang, Jian Sun, Xiao-Ping Liao, Yu-Feng Zhou   +8 more
doaj   +2 more sources

Auranofin, identified by FDA-approved drug library screening, inhibits HBs antigen secretion via lysosomal damage. [PDF]

PLoS ONE
Background and aimHepatitis B surface antigen (HBsAg) is associated with hepatocellular carcinoma risk and immune exhaustion and contributes to hepatitis B virus (HBV) persistence. Current anti-HBV treatments have a limited ability to reduce HBsAg levels.
Akiyoshi Shimoda, Kazuhiro Murai, Hayato Hikita, Satoshi Minami, Takayuki Miyake, Shinji Kuriki, Emi Sometani, Jihyun Sung, Satoshi Shigeno, Yuichiro Higuchi, Kazuki Maesaka, Kumiko Shirai, Yuki Tahata, Yoshinobu Saito, Takahiro Kodama, Takeshi Takahashi, Hiroshi Suemizu, Tetsuo Takehara   +17 more
doaj   +2 more sources

Antiproliferative effect of gold(I) compound auranofin through inhibition of STAT3 and telomerase activity in MDA-MB 231 human breast cancer cells [PDF]

BMB Reports, 2013
Signal transducer and activator of transcription 3 (STAT3) andtelomerase are considered attractive targets for anticancertherapy. The in vitro anticancer activity of the gold(I) compoundauranofin was investigated using MDA-MB 231 human breastcancer cells,
Nam-Hoon Kim, Hyo Jung Park, Mi-Kyung Oh   +2 more
exaly   +2 more sources

Potential Anticancer Activity of Auranofin

Chemical and Pharmaceutical Bulletin, 2019
Gold compounds have a long history of use in medicine. Auranofin was developed more than 30 years ago as an oral therapy for rheumatoid arthritis. Now, however, auranofin is rarely used in clinical practice despite its efficacy for treating rheumatoid arthritis because more novel antirheumatic medications are available.
Takefumi Onodera, Isao Momose, Manabu Kawada   +2 more
exaly   +6 more sources

Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation [PDF]

Nature Communications
Auranofin, an FDA-approved antirheumatic gold drug, has gained ongoing interest in clinical studies for treating advanced or recurrent tumors. However, gold ion’s dynamic thiol exchange nature strongly attenuates its bioactivity due to the fast formation
Yuan Wang, Bei Cao, Qianqian Wang, Sinan Zhong, Xin Fang, Junjian Wang, Albert S. C. Chan, Xiaolin Xiong, Taotao Zou   +8 more
doaj   +2 more sources