FEBS Journal, 2000 The mammalian thioredoxin reductases (TrxRs) are a family of selenium-containing pyridine nucleotide-disulphide oxidoreductases with mechanistic and sequence identity, including a conserved -Cys-Val-Asn-Val-Gly-Cys- redox catalytic site, to glutathione reductases.
Katja Becker, P F Wang, M L Ludwig
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Physiological functions of thioredoxin and thioredoxin reductase [PDF]
FEBS Journal, 2000 Thioredoxin, thioredoxin reductase and NADPH, the thioredoxin system, is ubiquitous from Archea to man. Thioredoxins, with a dithiol/disulfide active site (CGPC) are the major cellular protein disulfide reductases; they therefore also serve as electron donors for enzymes such as ribonucleotide reductases, thioredoxin peroxidases (peroxiredoxins) and ...
Arne Holmgren, Elias Arner, E S Arner
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Role of thioredoxin reductase (TrxB) in oxidative stress response of Francisella tularensis live vaccine strain [PDF]
Journal of BacteriologyFrancisella tularensis is an important human pathogen responsible for causing tularemia in the Northern Hemisphere. Francisella has been developed as a biological weapon in the past due to its extremely high virulence. F.
Matthew Higgs +4 more
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Cell Reports, 2017 Energetic nutrients are oxidized to sustain high intracellular NADPH/NADP+ ratios. NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively ...
Arne Holmgren +2 more
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Thioredoxin System in Insects: Uncovering the Roles of Thioredoxins and Thioredoxin Reductase beyond the Antioxidant Defences [PDF]
InsectsIncreased levels of reactive oxygen species (ROS) produced during aerobic metabolism in animals can negatively affect the intracellular redox status, cause oxidative stress and interfere with physiological processes in the cells.
Andrea Gřešková, Marek Petřivalský
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Evolutionarily Conserved Role of Thioredoxin Systems in Determining Longevity
Antioxidants, 2023 Thioredoxin and thioredoxin reductase are evolutionarily conserved antioxidant enzymes that protect organisms from oxidative stress. These proteins also play roles in redox signaling and can act as a redox-independent cellular chaperone.
Abdelrahman AlOkda +1 more
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JS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1. [PDF]
PLoS ONE, 2010 The selenoenzyme thioredoxin reductase 1 has a complex role relating to cell growth. It is induced as a component of the cellular response to potentially mutagenic oxidants, but also appears to provide growth advantages to transformed cells by inhibiting
Kornelia Edes +3 more
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Fluorogenic probes for thioredoxin reductase activity
Results in Chemistry, 2021 The thioredoxin system is vital in maintaining the cellular redox state and is implicated in various cancers and other diseases. It comprises of thioredoxin reductase, thioredoxin and NADPH.
Tendai J. Mafireyi +2 more
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The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition. [PDF]
PLoS ONE, 2016 BACKGROUND:The entry of HIV into its host cell is an interesting target for chemotherapeutic intervention in the life-cycle of the virus. During entry, reduction of disulfide bridges in the viral envelope glycoprotein gp120 by cellular oxidoreductases is
Kathrin Reiser +9 more
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Tissue Distribution and Activity of Thioredoxin Reductase in Pancreatic Carcinoma [PDF]
Middle East Journal of Cancer, 2019 Background: Thioredoxin, NADPH, and thioredoxin reductase form the thioredoxinsystem which exists in all living cells. Oxidants have a major role in cancer pathogenesis;therefore, it is necessary to study the role of redox-active compounds such as ...
Faezeh Sadrabadi Haghighi +3 more
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