Role of thioredoxin reductase (TrxB) in oxidative stress response of Francisella tularensis live vaccine strain [PDF]
Journal of BacteriologyFrancisella tularensis is an important human pathogen responsible for causing tularemia in the Northern Hemisphere. Francisella has been developed as a biological weapon in the past due to its extremely high virulence. F.
Matthew Higgs +4 more
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Thioredoxin System in Insects: Uncovering the Roles of Thioredoxins and Thioredoxin Reductase beyond the Antioxidant Defences [PDF]
InsectsIncreased levels of reactive oxygen species (ROS) produced during aerobic metabolism in animals can negatively affect the intracellular redox status, cause oxidative stress and interfere with physiological processes in the cells.
Andrea Gřešková, Marek Petřivalský
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Cell Reports, 2017 Energetic nutrients are oxidized to sustain high intracellular NADPH/NADP+ ratios. NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively ...
Justin R Prigge +2 more
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Evolutionarily Conserved Role of Thioredoxin Systems in Determining Longevity
Antioxidants, 2023 Thioredoxin and thioredoxin reductase are evolutionarily conserved antioxidant enzymes that protect organisms from oxidative stress. These proteins also play roles in redox signaling and can act as a redox-independent cellular chaperone.
Abdelrahman AlOkda +1 more
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Fluorogenic probes for thioredoxin reductase activity
Results in Chemistry, 2021 The thioredoxin system is vital in maintaining the cellular redox state and is implicated in various cancers and other diseases. It comprises of thioredoxin reductase, thioredoxin and NADPH.
Tendai J. Mafireyi +2 more
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JS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1. [PDF]
PLoS ONE, 2010 The selenoenzyme thioredoxin reductase 1 has a complex role relating to cell growth. It is induced as a component of the cellular response to potentially mutagenic oxidants, but also appears to provide growth advantages to transformed cells by inhibiting
Kornelia Edes +3 more
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The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition. [PDF]
PLoS ONE, 2016 BACKGROUND:The entry of HIV into its host cell is an interesting target for chemotherapeutic intervention in the life-cycle of the virus. During entry, reduction of disulfide bridges in the viral envelope glycoprotein gp120 by cellular oxidoreductases is
Kathrin Reiser +9 more
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Tissue Distribution and Activity of Thioredoxin Reductase in Pancreatic Carcinoma [PDF]
Middle East Journal of Cancer, 2019 Background: Thioredoxin, NADPH, and thioredoxin reductase form the thioredoxinsystem which exists in all living cells. Oxidants have a major role in cancer pathogenesis;therefore, it is necessary to study the role of redox-active compounds such as ...
Faezeh Sadrabadi Haghighi +3 more
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The over expression of thioredoxin during malignancies [PDF]
Reviews in Clinical Medicine, 2014 Thioredoxin system comprised of thiorexin and NADPH dependent thiorexin reductase, is responsible for redox regulation of cells by controlling the apoptosis, proliferation and other vital processes of cells.
Shahaboddin Shabani +2 more
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Molecular docking studies of N-Heterocyclic Carbene molecules with Thioredoxin Reductase and DNA
Cumhuriyet Science Journal, 2021 Thioredoxin which is induced by thioredoxin reductase causes the proliferation of cancerous cells and metastasis due to its effects on cell growth, besides its regulatory effects on the amount of reactive oxygen species.
Elvan Üstün, Neslihan Şahin
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