Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells. [PDF]
PLoS ONE, 2008 BackgroundSecTRAPs (selenium compromised thioredoxin reductase-derived apoptotic proteins) can be formed from the selenoprotein thioredoxin reductase (TrxR) by targeting of its selenocysteine (Sec) residue with electrophiles, or by its removal through C ...
Karin Anestål +3 more
doaj +1 more source
Molecular Pharmacology and Antitumor Activity of Palmarumycin-Based Inhibitors of Thioredoxin Reductase. [PDF]
, 2006 The cytosolic thioredoxin redox system composed of thioredoxin-1 and the NADPH-dependent thioredoxin reductase-1 reductase is an important regulator of cell growth and survival.
Lynch, Stephen M +4 more
core +1 more source
Redox Systems in Botrytis cinerea: Impact on Development and Virulence
Molecular Plant-Microbe Interactions, 2014 The thioredoxin system is of great importance for maintenance of cellular redox homeostasis. Here, we show that it has a severe influence on virulence of Botrytis cinerea, demonstrating that redox processes are important for host-pathogen interactions in
Anne Viefhues +3 more
doaj +1 more source
Stromal response to prostate cancer: nanotechnology-based detection of thioredoxin-interacting protein partners distinguishes prostate cancer associated stroma from that of benign prostatic hyperplasia. [PDF]
PLoS ONE, 2013 Histological staining of reactive stroma has been shown to be a predictor of biochemical recurrence in prostate cancer, however, molecular markers of the stromal response to prostate cancer have not yet been fully delineated.
Elizabeth Singer +7 more
doaj +1 more source
Structure-functional Characterization of Mammalian Redox Proteins: Methionine sulfoxide reductase B1 (MsrB1), Glutaredoxin domain (Grx) of TGR, and Thioredoxin (Trx) [PDF]
, 2013 This thesis was written at the Department of Biotechnology of Norwegian University of Science and Technology (NTNU) and made as a completion of the three-year PhD program.
Dobrovolska, Olena
core +1 more source
Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense. [PDF]
PLoS Pathogens, 2016 Mycobacterium tuberculosis (Mtb) must cope with exogenous oxidative stress imposed by the host. Unlike other antioxidant enzymes, Mtb's thioredoxin reductase TrxB2 has been predicted to be essential not only to fight host defenses but also for in vitro ...
Kan Lin +6 more
doaj +1 more source
Nature Communications, 2018 Thioredoxin (Trx), Trx reductase, Txnip and NADPH together comprise the Trx system. Here the authors make a T cell-specific thioredoxin reductase-1 knockout mouse to show how this system reprograms cellular metabolism to enable T cell development ...
Jonathan Muri +9 more
doaj +1 more source
Thioredoxin and thioredoxin-reductase protein levels.
, 2016 Thioredoxin and thioredoxin-reductase protein levels.
Galina Zeltcer (2890028) +4 more
core +1 more source
Angewandte Chemie, EarlyView.Oncogenic MYC is a transcription factor that is difficult to inhibit. However, precise positioning of an acrylamide electrophile in MAX to covalently bond to the unique Cys438 in MYC, enabled shortening and optimizing of MAX‐derived, helix‐constrained peptides with high‐affinity and selectivity.
Aline Dantas de Araujo +7 more
wiley +2 more sources
Thioredoxin reductase: An emerging pharmacologic target for radiosensitization of cancer
Translational Oncology, 2022 Novel agents are required to increase the radiosensitivity of cancer and improve the outcome of radiotherapy. Thioredoxin (Trx) and thioredoxin reductase (TrxR) reduce the oxidized cysteine thiols in several proteins, which regulate cellular redox ...
Raghavendra S. Patwardhan +2 more
doaj +1 more source