Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells. [PDF]
PLoS ONE, 2008 BackgroundSecTRAPs (selenium compromised thioredoxin reductase-derived apoptotic proteins) can be formed from the selenoprotein thioredoxin reductase (TrxR) by targeting of its selenocysteine (Sec) residue with electrophiles, or by its removal through C ...
Karin Anestål +3 more
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Genomic organisation and alternative splicing of mouse and human thioredoxin reductase 1 genes
BMC Genomics, 2001 Background Thioredoxin reductase (TR) is a redox active protein involved in many cellular processes as part of the thioredoxin system. Presently there are three recognised forms of mammalian thioredoxin reductase designated as TR1, TR3 and TGR, that ...
Tonissen Kathryn F, Osborne Simone A
doaj +1 more source
Structural analysis of glutaredoxin domain of Mus musculus thioredoxin glutathione reductase. [PDF]
PLoS ONE, 2012 Thioredoxin glutathione reductase (TGR) is a member of the mammalian thioredoxin reductase family that has a monothiol glutaredoxin (Grx) domain attached to the thioredoxin reductase module.
Olena Dobrovolska +3 more
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Crystal structure of the human thioredoxin reductase–thioredoxin complex [PDF]
Nature Communications, 2011 Thioredoxin reductase 1 (TrxR1) is a homodimeric flavoprotein crucially involved in the regulation of cellular redox homeostasis, growth, and differentiation. Its importance in various diseases makes TrxR1 a highly interesting drug target. Here we present the first crystal structures of human TrxR1 in complex with its substrate thioredoxin (Trx).
Fritz-Wolf, K. +4 more
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Thioredoxin Reductase and its Inhibitors [PDF]
Current Protein & Peptide Science, 2014 Thioredoxin plays a crucial role in a wide number of physiological processes, which span from reduction of nucleotides to deoxyriboucleotides to the detoxification from xenobiotics, oxidants and radicals. The redox function of Thioredoxin is critically dependent on the enzyme Thioredoxin NADPH Reductase (TrxR).
SACCOCCIA, FULVIO +6 more
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The thioredoxin reductase system of mycoplasmas [PDF]
Microbiology, 1997 Representative species of the Mollicutes possess a thioredoxin reductase system (NTS) composed of a low-molecular-mass thioredoxin (TRX) and NADPH-binding thioredoxin reductase (NTR). The TRXs of Mycoplasma pneumoniae and M. capricolum have molecular masses of 11.2 and 12 kDa, respectively, and are stable at 90 °C for 10 min.
G, Ben-Menachem +4 more
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Redox Systems in Botrytis cinerea: Impact on Development and Virulence
Molecular Plant-Microbe Interactions, 2014 The thioredoxin system is of great importance for maintenance of cellular redox homeostasis. Here, we show that it has a severe influence on virulence of Botrytis cinerea, demonstrating that redox processes are important for host-pathogen interactions in
Anne Viefhues +3 more
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Stromal response to prostate cancer: nanotechnology-based detection of thioredoxin-interacting protein partners distinguishes prostate cancer associated stroma from that of benign prostatic hyperplasia. [PDF]
PLoS ONE, 2013 Histological staining of reactive stroma has been shown to be a predictor of biochemical recurrence in prostate cancer, however, molecular markers of the stromal response to prostate cancer have not yet been fully delineated.
Elizabeth Singer +7 more
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Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense. [PDF]
PLoS Pathogens, 2016 Mycobacterium tuberculosis (Mtb) must cope with exogenous oxidative stress imposed by the host. Unlike other antioxidant enzymes, Mtb's thioredoxin reductase TrxB2 has been predicted to be essential not only to fight host defenses but also for in vitro ...
Kan Lin +6 more
doaj +1 more source
Nature Communications, 2018 Thioredoxin (Trx), Trx reductase, Txnip and NADPH together comprise the Trx system. Here the authors make a T cell-specific thioredoxin reductase-1 knockout mouse to show how this system reprograms cellular metabolism to enable T cell development ...
Jonathan Muri +9 more
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