Results 21 to 30 of about 49,631 (209)

Novel potential interacting partners of fibronectin in spontaneous animal model of interstitial cystitis [PDF]

, 2012
Feline idiopathic cystitis (FIC) is the only spontaneous animal model for human interstitial cystitis (IC), as both possess a distinctive chronical and relapsing character. Underlying pathomechanisms of both diseases are not clearly established yet.
Amann, Barbara, Hauck Stefanie M., Kerstin N. Euler, Barbara Amann, Dorsch Roswitha, Euler, K.N., Cornelia A Deeg, Dorsch, Roswitha, Roswitha Dorsch, Kerstin N Euler, Euler Kerstin N., Deeg Cornelia A., Amann Barbara, Treutlein, Gudrun, Stefanie M Hauck, Stefanie M. Hauck, Deeg, Cornelia A., Treutlein Gudrun, Hauck, Stefanie M., Euler, Kerstin N., Cornelia A. Deeg, Amann, B., Hartmann, Katrin, Hartmann Katrin, Hauck, S.M., Hartmann, K., Katrin Hartmann, Treutlein, G., Gudrun Treutlein, Deeg, C.A., Dorsch, R.   +30 more
core   +1 more source

Structural analysis of glutaredoxin domain of Mus musculus thioredoxin glutathione reductase. [PDF]

PLoS ONE, 2012
Thioredoxin glutathione reductase (TGR) is a member of the mammalian thioredoxin reductase family that has a monothiol glutaredoxin (Grx) domain attached to the thioredoxin reductase module.
Olena Dobrovolska, Elena Shumilina, Vadim N Gladyshev, Alexander Dikiy   +3 more
doaj   +1 more source

Genomic organisation and alternative splicing of mouse and human thioredoxin reductase 1 genes

BMC Genomics, 2001
Background Thioredoxin reductase (TR) is a redox active protein involved in many cellular processes as part of the thioredoxin system. Presently there are three recognised forms of mammalian thioredoxin reductase designated as TR1, TR3 and TGR, that ...
Tonissen Kathryn F, Osborne Simone A
doaj   +1 more source

Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells. [PDF]

PLoS ONE, 2008
BackgroundSecTRAPs (selenium compromised thioredoxin reductase-derived apoptotic proteins) can be formed from the selenoprotein thioredoxin reductase (TrxR) by targeting of its selenocysteine (Sec) residue with electrophiles, or by its removal through C ...
Karin Anestål, Stefanie Prast-Nielsen, Narimantas Cenas, Elias S J Arnér   +3 more
doaj   +1 more source

A Crystalline and Thermally Stable Selenocysteine Selenenic Acid

Angewandte Chemie, EarlyView.
The long‐sought catalytic intermediate of selenoproteins, selenocysteine selenenic acid (Sec–SeOH), is isolated for the first time at ambient temperature. A bioinspired selenopeptide sequence encapsulated within a protective molecular cradle and an oxidant‐free route from selenenyl iodide (Sec–SeI) enable the isolation of Sec–SeOH. Contrary to the long‐
Ryosuke Masuda, Satoru Kuwano, Kei Goto
wiley   +2 more sources

Redox Systems in Botrytis cinerea: Impact on Development and Virulence

Molecular Plant-Microbe Interactions, 2014
The thioredoxin system is of great importance for maintenance of cellular redox homeostasis. Here, we show that it has a severe influence on virulence of Botrytis cinerea, demonstrating that redox processes are important for host-pathogen interactions in
Anne Viefhues, Jens Heller, Nora Temme, Paul Tudzynski   +3 more
doaj   +1 more source

Stromal response to prostate cancer: nanotechnology-based detection of thioredoxin-interacting protein partners distinguishes prostate cancer associated stroma from that of benign prostatic hyperplasia. [PDF]

PLoS ONE, 2013
Histological staining of reactive stroma has been shown to be a predictor of biochemical recurrence in prostate cancer, however, molecular markers of the stromal response to prostate cancer have not yet been fully delineated.
Elizabeth Singer, Jennifer Linehan, Gail Babilonia, S Ashraf Imam, David Smith, Sofia Loera, Timothy Wilson, Steven Smith   +7 more
doaj   +1 more source

Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense. [PDF]

PLoS Pathogens, 2016
Mycobacterium tuberculosis (Mtb) must cope with exogenous oxidative stress imposed by the host. Unlike other antioxidant enzymes, Mtb's thioredoxin reductase TrxB2 has been predicted to be essential not only to fight host defenses but also for in vitro ...
Kan Lin, Kathryn M O'Brien, Carolina Trujillo, Ruojun Wang, Joshua B Wallach, Dirk Schnappinger, Sabine Ehrt   +6 more
doaj   +1 more source

Selenium in biology: Facts and medical perspectives [PDF]

, 2000
Several decades after the discovery of setenium as an essential trace element in vertebrates approximately 20 eukaryotic and more than 15 prokaryotic selenoproteins containing the 21(st) proteinogenic amino acid, selenocysteine, have been identified ...
Flohé, Leopold, Gärtner, Roland, Köhrle, Josef, Brigelius-Flohé, Regina, Böck, August, Meyer, Ortwin   +5 more
core   +1 more source

The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation

Nature Communications, 2018
Thioredoxin (Trx), Trx reductase, Txnip and NADPH together comprise the Trx system. Here the authors make a T cell-specific thioredoxin reductase-1 knockout mouse to show how this system reprograms cellular metabolism to enable T cell development ...
Jonathan Muri, Sebastian Heer, Mai Matsushita, Lea Pohlmeier, Luigi Tortola, Tobias Fuhrer, Marcus Conrad, Nicola Zamboni, Jan Kisielow, Manfred Kopf   +9 more
doaj   +1 more source