Results 31 to 40 of about 49,631 (209)

Thioredoxin reductase: An emerging pharmacologic target for radiosensitization of cancer

Translational Oncology, 2022
Novel agents are required to increase the radiosensitivity of cancer and improve the outcome of radiotherapy. Thioredoxin (Trx) and thioredoxin reductase (TrxR) reduce the oxidized cysteine thiols in several proteins, which regulate cellular redox ...
Raghavendra S. Patwardhan, Deepak Sharma, Santosh K. Sandur   +2 more
doaj   +1 more source

Thioredoxin Inhibitors Attenuate Platelet Function and Thrombus Formation.

PLoS ONE, 2016
Thioredoxin (Trx) is an oxidoreductase with important physiological function. Imbalances in the NADPH/thioredoxin reductase/thioredoxin system are associated with a number of pathologies, particularly cancer, and a number of clinical trials for ...
Clive Metcalfe, Anjana Ramasubramoni, Giordano Pula, Matthew T Harper, Stuart J Mundell, Carmen H Coxon   +5 more
doaj   +1 more source

Oligo-Carrageenan Kappa-Induced Reducing Redox Status and Activation of TRR/TRX System Increase the Level of Indole-3-acetic Acid, Gibberellin A3 and trans-Zeatin in Eucalyptus globulus Trees

Molecules, 2014
Eucalyptus globulus trees treated with oligo-carrageenan (OC) kappa showed an increase in NADPH, ascorbate and glutathione levels and activation of the thioredoxin reductase (TRR)/thioredoxin (TRX) system which enhance photosynthesis, basal metabolism ...
Alberto González, Rodrigo A. Contreras, Gustavo Zúiga, Alejandra Moenne   +3 more
doaj   +1 more source

Thioredoxin and thioredoxin-reductase protein levels.

, 2016
Thioredoxin and thioredoxin-reductase protein levels.
Galina Zeltcer (2890028), Mordechai Chevion (119370), Benjamin Drenger (2890031), Hilbert Grievink (2890025), Eduard Berenshtein (119363)   +4 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

The Barley Grain Thioredoxin System – an Update

Frontiers in Plant Science, 2013
Thioredoxin reduces disulfide bonds and play numerous important functions in plants. In cereal seeds, cytosolic h-type thioredoxin facilitates the release of energy reserves during the germination process and is recycled by NADPH-dependent thioredoxin ...
Per eHägglund, Olof eBjörnberg, Nicolas eNavrot, Johanne eMørch Jensen, Kenji eMaeda, Kristine eKirkensgaard, Azar eShahpiri, Abida eSultan, Jakob eBunkenborg, Frank eGubler, José Maria Barrero, Anette eHenriksen, Christine eFinnie, Birte eSvensson   +13 more
doaj   +1 more source

Measurement of thioredoxin and thioredoxin reductase

, 2001
The thioredoxin system is ubiquitous, providing reducing equivalents to essential biosynthetic enzymes like ribonucleotide reductase. It is essential for cellular redox regulation, control of oxidative stress, and protection against oxidative damage ...
Holmgren, A,, Arnér, ES
core   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Did a shared thioredoxin-reductase gene mutation lead to maternal peripartum cardiomyopathy and fatal dilated cardiomyopathy in her son? A case report

Case Reports in Women's Health, 2020
Peripartum cardiomyopathy (PPCM) is characterized by development of left ventricular systolic dysfunction and heart failure that occurs towards the end of pregnancy or in the postpartum period in the absence of structural heart disease.
Indranee Rajapreyar, Rachel Sinkey, Salpy V. Pamboukian, Alan Tita   +3 more
doaj   +1 more source

Interaction of recombinant form of NADPH-dependent thioredoxin reductase from rice with thioredoxin from two plant and bacterial sources [PDF]

مجله بیوتکنولوژی کشاورزی, 2014
Maintaining redox homeostasis in the cell is critical for different cellular metabolisms and signal transduction pathways. In plants different molecular mechanisms are involved in maintaining cellular redox homeostasis.
Hadiyeh Eslam Panah, Azar Shah Piri, Ehsan Sheykholeslam   +2 more
doaj   +1 more source