Results 11 to 20 of about 45,317 (203)
The over expression of thioredoxin during malignancies [PDF]
Reviews in Clinical Medicine, 2014 Thioredoxin system comprised of thiorexin and NADPH dependent thiorexin reductase, is responsible for redox regulation of cells by controlling the apoptosis, proliferation and other vital processes of cells.
Shahaboddin Shabani +2 more
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Molecular docking studies of N-Heterocyclic Carbene molecules with Thioredoxin Reductase and DNA
Cumhuriyet Science Journal, 2021 Thioredoxin which is induced by thioredoxin reductase causes the proliferation of cancerous cells and metastasis due to its effects on cell growth, besides its regulatory effects on the amount of reactive oxygen species.
Elvan Üstün, Neslihan Şahin
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Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductase. [PDF]
PLoS Biology, 2007 Metronidazole, a 5-nitroimidazole drug, has been the gold standard for several decades in the treatment of infections with microaerophilic protist parasites, including Entamoeba histolytica. For activation, the drug must be chemically reduced, but little
David Leitsch +4 more
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Characterizing roles for the glutathione reductase, thioredoxin reductase and thioredoxin peroxidase-encoding genes of Magnaporthe oryzae during rice blast disease. [PDF]
PLoS ONE, 2014 Understanding how pathogenic fungi adapt to host plant cells is of major concern to securing global food production. The hemibiotrophic rice blast fungus Magnaporthe oryzae, cause of the most serious disease of cultivated rice, colonizes leaf cells ...
Jessie Fernandez, Richard A Wilson
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Thioredoxin reductase as a pharmacological target
Pharmacological Research, 2021 Thioredoxin reductases (TrxRs) belong to the pyridine nucleotide disulfide oxidoreductase family enzymes that reduce thioredoxin (Trx). The couple TrxR and Trx is one of the major antioxidant systems that control the redox homeostasis in cells. The thioredoxin system, comprised of TrxR, Trx and NADPH, exerts its activities via a disulfide-dithiol ...
Geir Bjørklund +4 more
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Lipoamide Dehydrogenase, Glutathione Reductase, Thioredoxin Reductase, and Thioredoxin
Journal of Biological Chemistry, 1967 Abstract A procedure has been developed for the purification of lipoamide dehydrogenase, glutathione reductase, thioredoxin reductase, and thioredoxin from Escherichia coli B, in which the four proteins are purified together in the initial stages separation effected in two steps, and the individual purifications completed in one or two steps.
C H, Williams +3 more
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Redox Biology, 2016 Selenium participates in the antioxidant defense mainly through a class of selenoproteins, including thioredoxin reductase. Epigallocatechin-3-gallate (EGCG) is the most abundant and biologically active catechin in green tea.
Ruixia Dong +6 more
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Redox Biology, 2017 Myeloperoxidase produces strong oxidants during the immune response to destroy invading pathogens. However, these oxidants can also cause tissue damage, which contributes to the development of numerous inflammatory diseases. Selenium containing compounds,
Luke Carroll +5 more
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Cloning of thioredoxin h reductase and characterization of the thioredoxin reductase–thioredoxin h system from wheat [PDF]
Biochemical Journal, 2002 Thioredoxins h are ubiquitous proteins reduced by NADPH— thioredoxin reductase (NTR). They are able to reduce disulphides in target proteins. In monocots, thioredoxins h accumulate at high level in seeds and show a predominant localization in the nucleus of seed cells.
Pérez Ruiz, Juan Manuel +2 more
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Mitochondrial Thioredoxin-Glutathione Reductase from Larval Taenia crassiceps (Cysticerci)
Journal of Parasitology Research, 2010 Mitochondrial thioredoxin-glutathione reductase was purified from larval Taenia crassiceps (cysticerci). The preparation showed NADPH-dependent reductase activity with either thioredoxin or GSSG, and was able to perform thiol/disulfide exchange reactions.
Alberto Guevara-Flores +5 more
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