Results 51 to 60 of about 162,334 (201)

Dual action of sulforaphane in the regulation of thioredoxin reductase and thioredoxin in human HepG2 and Caco-2 cells

, 2007
We have previously demonstrated that sulforaphane is a potent inducer for thioredoxin reductase in HepG2 and MCF-7 cells (Zhang et al. Carcinogenesis2003, 24, 497−503; Wang et al. J. Agric. Food Chem.2005, 53, 1417−1421).
Beckett, Geoffrey J., Wang, Wei, Plumb, Geoff W., Bacon, James R., Bao, Yongping, Howie, A. Forbes   +5 more
core   +1 more source

An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir

Advanced Science, EarlyView.
FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun, Rohan Narayan, Santhosh Kambaiah Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Siva Shanmugam Selvaraj, Gudepalya Renukaiah Rudramurthy, Chakenahalli Naveenkumar, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi   +13 more
wiley   +1 more source

Structural model of the Plasmodium falciparum Thioredoxin reductase:a novel target for antimalarial drugs [PDF]

Journal of Vector Borne Diseases, 2009
Background: Malaria, a scourge of mankind, imposes a huge socioeconomic burden in tropicalcountries. Emergence of multi-drug resistant malarial parasites impels us to explore novel drugtargets.
Amit Kumar Banerjee, Neelima Arora, U.S.N. Murty   +2 more
doaj  

Yeast thioredoxin reductase Trr1p controls TORC1-regulated processes

Scientific Reports, 2018
The thioredoxin system plays a predominant role in the control of cellular redox status. Thioredoxin reductase fuels the system with reducing power in the form of NADPH. The TORC1 complex promotes growth and protein synthesis when nutrients, particularly
Cecilia Picazo, Emilia Matallana, Agustín Aranda   +2 more
doaj   +1 more source

Harnessing Methylselenol (CH3SeH): A Highly Effective Platform for Stimuli‐Responsive Delivery With Therapeutic Potential

Advanced Science, EarlyView.
Tools for controlled selenol delivery are crucial for exploring Se‐related biology and medicine, but compound platforms for triggerable release of CH3SeH remain lacking. Herein, we report the first general triggered platform (TD‐MSe) for efficient cyclization release of CH3SeH in live cells.
Wenfang Liang, Liyue Wang, Xuan Wang, Xinran Li, Hao Xing, Lu Sun, Zhen Xi, Long Yi   +7 more
wiley   +1 more source

Methylglyoxal Causes Dysfunction of Thioredoxin and Thioredoxin Reductase in Endothelial Cells

Journal of Pharmacological Sciences, 2009
Methylglyoxal (MG), a reactive dicarbonyl produced during glucose metabolism, induces oxidative stress and apoptosis. Under hyperglycemic conditions, the abnormal accumulation of MG is related to the development of diabetic complications. We examined the
Ryosuke Tatsunami, Tatsuya Oba, Kyohei Takahashi, Yoshiko Tampo   +3 more
doaj   +1 more source

Effect of thioredoxin deletion and p53 cysteine replacement on human p53 activity in wild-type and thioredoxin reductase null yeast

, 2009
Reporter gene transactivation by human p53 is inhibited in budding yeast lacking the TRR1 gene encoding thioredoxin reductase. To investigate the role of thioredoxin in controlling p53 activity, the level of reporter gene transactivation by p53 was ...
Stoner, Christopher S., Pearson, George D., Lopez, Nathan I., Merrill, Gary Frederic, Merwin, Jason R., Koç, Ahmet   +5 more
core   +1 more source

Effect of Thioredoxin Deletion and p53 Cysteine Replacement on Human p53 Activity in Wild-Type and Thioredoxin Reductase Null Yeast

, 2016
Reporter gene transactivation by human p53 is inhibited in budding yeast lacking the TRR1 gene encoding thioredoxin reductase. To investigate the role of thioredoxin in controlling p53 activity, the level of reporter gene transactivation by p53 was ...
Christopher S. Stoner (2348095), George D. Pearson (2348104), Nathan I. Lopez (2348101), Jason R. Merwin (2348092), Ahmet Koç (2348098), Gary F. Merrill (262243)   +5 more
core   +1 more source

Disulfide Bond–Modified Proteomics Reveals the Effects of Riboflavin on Protein Folding Dynamics

Animal Research and One Health, EarlyView.
Riboflavin deficiency impairs oxidative protein folding, causing ER misfolded protein accumulation, CHOP activation, and apoptosis, revealing a role of riboflavin in proteostasis. ABSTRACT Riboflavin is a crucial micronutrient essential for maintaining cellular homeostasis, acting as an important precursor for flavoproteins that utilize flavin ...
Bo Zhang, Shuisheng Hou, Jing Tang
wiley   +1 more source

Overexpression of chloroplast NADPH-dependent thioredoxin reductase in Arabidopsis enhances leaf growth and elucidates in-vivo function of reductase and thioredoxin domains

Frontiers in Plant Science, 2013
Plant chloroplasts have versatile thioredoxin systems including two thioredoxin reductases and multiple types of thioredoxins. Plastid-localized NADPH-dependent thioredoxin reductase (NTRC) contains both reductase (NTRd) and thioredoxin (TRXd) domains in
Jouni eToivola, Lauri eNikkanen, Käthe M. Dahlström, Tiina A. Salminen, Anna eLepistö, Florence eVignols, Eevi eRintamäki   +6 more
doaj   +1 more source