Results 51 to 60 of about 49,631 (209)

Structural model of the Plasmodium falciparum Thioredoxin reductase:a novel target for antimalarial drugs [PDF]

Journal of Vector Borne Diseases, 2009
Background: Malaria, a scourge of mankind, imposes a huge socioeconomic burden in tropicalcountries. Emergence of multi-drug resistant malarial parasites impels us to explore novel drugtargets.
Amit Kumar Banerjee, Neelima Arora, U.S.N. Murty   +2 more
doaj  

Yeast thioredoxin reductase Trr1p controls TORC1-regulated processes

Scientific Reports, 2018
The thioredoxin system plays a predominant role in the control of cellular redox status. Thioredoxin reductase fuels the system with reducing power in the form of NADPH. The TORC1 complex promotes growth and protein synthesis when nutrients, particularly
Cecilia Picazo, Emilia Matallana, Agustín Aranda   +2 more
doaj   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Inhibition of thioredoxin reductase by lanthanum chloride

, 2012
Lanthanum chloride (LaCl3) is a good inhibitor of both the cytosolic and mitochondrial thioredoxin reductase with IC50 values of 1.75 and 7.46 μM, respectively.
CITTA, ANNA, CESARO, LUCA, RIGOBELLO, MARIA PIA, SCUTARI, GUIDO, BINDOLI, ALBERTO, FOLDA, ALESSANDRA   +5 more
core   +1 more source

Subchronic Exposure to Arsenic and Nickel Triggers Nitrosative Stress and Histological Alterations in the Rat Liver

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima, Luiz Otávio Guimarães‐Ervilha, Isabela Pereira da Silva Bento, Renê Chagas da Silva, Mariana Machado‐Neves   +4 more
wiley   +1 more source

Methylglyoxal Causes Dysfunction of Thioredoxin and Thioredoxin Reductase in Endothelial Cells

Journal of Pharmacological Sciences, 2009
Methylglyoxal (MG), a reactive dicarbonyl produced during glucose metabolism, induces oxidative stress and apoptosis. Under hyperglycemic conditions, the abnormal accumulation of MG is related to the development of diabetic complications. We examined the
Ryosuke Tatsunami, Tatsuya Oba, Kyohei Takahashi, Yoshiko Tampo   +3 more
doaj   +1 more source

Acetylated Thioredoxin Reductase 1 Resists Oxidative Inactivation

Frontiers in Chemistry, 2021
Thioredoxin Reductase 1 (TrxR1) is an enzyme that protects human cells against reactive oxygen species generated during oxidative stress or in response to chemotherapies. Acetylation of TrxR1 is associated with oxidative stress, but the function of TrxR1
David. E. Wright, Nikolaus Panaseiko, Patrick O’Donoghue, Patrick O’Donoghue   +3 more
doaj   +1 more source

Activation of translation via reduction by thioredoxin–thioredoxin reductase in Saccharomyces cerevisiae

, 2009
Previously we reported that in vitro translation activity in extracts of Saccharomyces cerevisiae was stimulated by dithiothreitol (DTT) and further increased by the addition of thioredoxin (TRX1) [Choi, S.K.
Jun, Kyung Ok, Choi, Sang Ki, Kim, Young-Bum, An, Jinseok, Song, Chin-Hee, Oh, Jae Hyeun   +5 more
core   +1 more source

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, EarlyView.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source

Liebig Review: Essential and Beneficial Elements in the Regulation of Cadmium Uptake and Tolerance in Crop Plants

Journal of Plant Nutrition and Soil Science, EarlyView.
ABSTRACT Cadmium (Cd2+) contamination in agricultural soils has been reported to pose risks to crop productivity, food safety, and human health. This review synthesizes current knowledge on the mechanisms by which essential (S, Zn, Fe, Mg, K, Ca) and beneficial (Si, Se, rare earth elements) elements mitigate Cd2+ toxicity in plants.
Maria Manzoor, Karl Hermann Mühling
wiley   +1 more source