Results 61 to 70 of about 162,334 (201)

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

A novel thermostable and halophilic thioredoxin reductase from the Red Sea Atlantis II hot brine pool.

PLoS ONE, 2019
The highly extreme conditions of the lower convective layer in the Atlantis II (ATII) Deep brine pool of the Red Sea make it an ideal environment for the search for novel enzymes that can function under extreme conditions.
Elham A Badiea, Ahmed A Sayed, Mohamad Maged, Walid M Fouad, Mahmoud M Said, Amr Y Esmat   +5 more
doaj   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

Comprehensive Evaluation of Commercial Antibodies for High Sensitivity Detection of EPO‐Doping on Western Blots

Drug Testing and Analysis, EarlyView.
A large‐scale evaluation of 164 commercially available anti‐human EPO antibodies was conducted to identify an alternative to clone AE7A5 anti‐EPO antibody used in doping control for the detection of erythropoiesis‐stimulating agents (ERAs) on Western blots.
Christian Reichel, Günter Gmeiner, Hans Geyer, Mario Thevis   +3 more
wiley   +1 more source

Characterization and enzymatic function of thioredoxin glutathione reductase in Orientobilharzia turkestanicum isolated from Xizang

BMC Veterinary Research
Orientobilharziasis, caused by Orientobilharzia turkestanicum, is a zoonotic parasitic disease that leads to significant economic losses in livestock and cercarial dermatitis in humans.
Wenqiang Tang, Yongcheng Yue, Bin Shi, Xialing Zhao, Yang Hong   +4 more
doaj   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Transactivational activity of the tumor suppressor protein p53 is dependent on thioredoxin reductase activity in mammalian cells [PDF]

Reporter gene transactivation by human p53 is inhibited in budding yeast lacking the TRR1 gene encoding thioredoxin reductase. Thioredoxin reductase specifically catalyzes the NADPH-dependent reduction of thioredoxin.
Merwin, Jason R.
core   +2 more sources

Novel potential interacting partners of fibronectin in spontaneous animal model of interstitial cystitis [PDF]

, 2012
Feline idiopathic cystitis (FIC) is the only spontaneous animal model for human interstitial cystitis (IC), as both possess a distinctive chronical and relapsing character. Underlying pathomechanisms of both diseases are not clearly established yet.
Amann, Barbara, Hauck Stefanie M., Kerstin N. Euler, Barbara Amann, Dorsch Roswitha, Euler, K.N., Cornelia A Deeg, Dorsch, Roswitha, Roswitha Dorsch, Kerstin N Euler, Euler Kerstin N., Deeg Cornelia A., Amann Barbara, Treutlein, Gudrun, Stefanie M Hauck, Stefanie M. Hauck, Deeg, Cornelia A., Treutlein Gudrun, Hauck, Stefanie M., Euler, Kerstin N., Cornelia A. Deeg, Amann, B., Hartmann, Katrin, Hartmann Katrin, Hauck, S.M., Hartmann, K., Katrin Hartmann, Treutlein, G., Gudrun Treutlein, Deeg, C.A., Dorsch, R.   +30 more
core   +2 more sources

The Serendipitous Discovery of Rollover Cyclometalation: From Unrecognized Observation to Transformative Chemistry

European Journal of Inorganic Chemistry, EarlyView.
Rollover cyclometalation is a distinctive variant of classical cyclometalation where a chelated heterocyclic ligand undergoes internal rotation, releasing one donor atom from coordination and subsequently activating a remote C─H bond with high regioselectivity.
Antonio Zucca, Maria I. Pilo
wiley   +1 more source

Inhibition of Tapeworm Thioredoxin and Glutathione Pathways by an Oxadiazole N-Oxide Leads to Reduced Mesocestoides vogae Infection Burden in Mice

Molecules, 2015
Parasitic flatworms cause serious infectious diseases that affect humans and livestock in vast regions of the world, yet there are few effective drugs to treat them. Thioredoxin glutathione reductase (TGR) is an essential enzyme for redox homeostasis in
Vivian Pasquet, Hugo Bisio, Gloria V. López, Laura Romanelli-Cedrez, Mariana Bonilla, Jenny Saldaña, Gustavo Salinas   +6 more
doaj   +1 more source