Results 71 to 80 of about 49,631 (209)

Dual action of sulforaphane in the regulation of thioredoxin reductase and thioredoxin in human HepG2 and Caco-2 cells

, 2007
We have previously demonstrated that sulforaphane is a potent inducer for thioredoxin reductase in HepG2 and MCF-7 cells (Zhang et al. Carcinogenesis2003, 24, 497−503; Wang et al. J. Agric. Food Chem.2005, 53, 1417−1421).
Beckett, Geoffrey J., Wang, Wei, Plumb, Geoff W., Bacon, James R., Bao, Yongping, Howie, A. Forbes   +5 more
core   +1 more source

Transcriptomic and proteomic signatures underlying nymphal adaptation and foam production in the forage pest Mahanarva spectabilis

Insect Molecular Biology, EarlyView.
RNA‐seq and Batelli gland proteomics of fifth‐instar Mahanarva spectabilis nymphs reveal transcripts and proteins associated with xylem feeding, foam production and environmental interaction. Functional annotation identified genes involved in osmoregulation, detoxification, chemosensation and stress responses, while proteomic analysis confirmed ...
Monique da Silva Bonjour, Angelo José Rinaldi, Eulálio Gutemberg Dias dos Santos, Gabriely Teixeira Bhering Faria, Ana Márcia Escocard de Azevedo Manhães, Jorge Fernando Pereira, Alexander Machado Auad, Maria Goreti de Almeida Oliveira, Humberto Josué de Oliveira Ramos   +8 more
wiley   +1 more source

Inhibition of Tapeworm Thioredoxin and Glutathione Pathways by an Oxadiazole N-Oxide Leads to Reduced Mesocestoides vogae Infection Burden in Mice

Molecules, 2015
Parasitic flatworms cause serious infectious diseases that affect humans and livestock in vast regions of the world, yet there are few effective drugs to treat them. Thioredoxin glutathione reductase (TGR) is an essential enzyme for redox homeostasis in
Vivian Pasquet, Hugo Bisio, Gloria V. López, Laura Romanelli-Cedrez, Mariana Bonilla, Jenny Saldaña, Gustavo Salinas   +6 more
doaj   +1 more source

Molecular Pharmacology and Antitumor Activity of Palmarumycin-Based Inhibitors of Thioredoxin Reductase. [PDF]

, 2006
The cytosolic thioredoxin redox system composed of thioredoxin-1 and the NADPH-dependent thioredoxin reductase-1 reductase is an important regulator of cell growth and survival.
Lynch, Stephen M, Kirkpatrick, D Lynn, Wipf, Peter, Powis, Garth, Birmingham, Anne   +4 more
core   +1 more source

Thioredoxin system modulates metabolic and stomatal responses to elevated CO2 in Arabidopsis

New Phytologist, EarlyView.
Integrative model of extraplastidial NADPH‐dependent thioredoxin reductase/thioredoxin system‐mediated regulation of stomatal function, redox homeostasis, and metabolic responses under ambient and elevated CO2 in Arabidopsis thaliana. Summary The NADPH‐dependent thioredoxin reductase/thioredoxin (NTR/TRX) system plays a central role in maintaining ...
Paula da Fonseca‐Pereira, Domingos F. Mélo Neto, Rita de Cássia Monteiro‐Batista, Daniel Gomes Coelho, Jaciara Lana‐Costa, Leonardo Perez de Souza, Ina Krahnert, Danilo M. Daloso, Jorge Gago, Alisdair R. Fernie, Wagner L. Araújo, Adriano Nunes‐Nesi   +11 more
wiley   +1 more source

Semisynthesis and Characterization of Mammalian Thioredoxin Reductase^†

, 2016
Thioredoxin reductase and thioredoxin constitute the cellular thioredoxin system, which provides reducing equivalents to numerous intracellular target disulfides. Mammalian thioredoxin reductase contains the rare amino acid selenocysteine.
Brian Eckenroth (2642749), Katharine Harris (2642752), Ronald T. Raines (369613), Robert J. Hondal (1306002), Anton A. Turanov (811577), Vadim N. Gladyshev (8009)   +5 more
core   +1 more source

The Circadian Oscillator Affects Both Glutathione Homeostasis and Its Response to Salt Stress in Arabidopsis thaliana

Plant, Cell &Environment, EarlyView.
ABSTRACT Glutathione, including reduced glutathione (GSH) and oxidized glutathione (GSSG), is the major non‐protein thiol‐based redox buffer. There are diurnal rhythms in total glutathione level and in this work, we investigate whether these oscillations might be indicative of circadian regulation of total glutathione homeostasis.
Desiré Cano‐Yelo, Raquel López‐Martínez, Francisca Sevilla, Alex A. R. Webb, Ana Jiménez, María Carmen Martí   +5 more
wiley   +1 more source

Glutathione reductase and thioredoxin reductase at the crossroad: The structure of Schistosoma mansoni thioredoxin glutathione reductase.

, 2008
Thioredoxin glutathione reductase (TGR) is a key flavoenzyme expressed by schistosomes that bridges two detoxification pathways crucial for the parasite survival in the host's organism.
BELLELLI, Andrea, Angelucci, F., Bellelli, A., Boumis, G., MIELE AE, ANGELUCCI, Francesco, DIMASTROGIOVANNI, Daniela, MIELE, Adriana Erica, BOUMIS G, DIMASTROGIOVANNI D, Brunori, M., BRUNORI, Maurizio, Dimastrogiovanni, D., BELLELLI A., BOUMIS, Giovanna, M. BRUNORI, Miele, A.E.   +16 more
core   +1 more source

Ro5‐4864, a ligand of the mitochondrial translocator protein, protects against heart failure in mice via regulation of the p62‐Keap1‐Nrf2 axis

The Journal of Physiology, EarlyView.
Abstract figure legend Graphical abstract of the proposed Ro5‐4864 mechanism of action via p62‐Keap1‐Nrf2 axis in heart failure. TSPO, the 18‐kDa mitochondrial translocator protein of the outer mitochondrial membrane, can directly interact with p62 (also known as SQSTM1), which is crucial for the degradation of damaged mitochondria by autophagy ...
Daphne A. Diloretto, Phung N. Thai, Gabriela Grigorean, Veneese J. Brown, Tjien Dwyer, Nipavan Chiamvimonvat, Elena N. Dedkova, Saul Schaefer   +7 more
wiley   +1 more source

Differential expression of disulfide reductase enzymes in a free-living platyhelminth (Dugesia dorotocephala).

PLoS ONE, 2017
A search of the disulfide reductase activities expressed in the adult stage of the free-living platyhelminth Dugesia dorotocephala was carried out. Using GSSG or DTNB as substrates, it was possible to obtain a purified fraction containing both GSSG and ...
Alberto Guevara-Flores, Álvaro Miguel Herrera-Juárez, José de Jesús Martínez-González, Irene Patricia Del Arenal Mena, Óscar Flores-Herrera, Juan Luis Rendón   +5 more
doaj   +1 more source