Results 91 to 100 of about 45,317 (203)
Macrophage: Biological Functions, Diseases, and Therapeutic Targets
Macrophages are sentinel innate immune cells that arise from embryonic precursors and bone marrow monocytes, displaying a functional continuum that transcends the classical M1 (pro‐inflammatory)/M2 (anti‐inflammatory) dichotomy. Under homeostatic conditions, balanced M1/M2 polarization preserves tissue integrity by coordinating immune surveillance ...
Bihang Sun +4 more
wiley +1 more source
Multidrug‐resistant (MDR) Gram‐negative bacteria account for a majority of fatal infections, and development of new antibiotic principles and drugs is therefore of outstanding importance.
Lili Zou +7 more
doaj +1 more source
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang +3 more
wiley +1 more source
Under the treatment of ferroptosis inducers, the expression of SEPHS2 is upregulated, driven by ATF4, to increase the biosynthesis of selenoproteins (e.g., GPX4) to promote resistance to ferroptosis. ABSTRACT While it has been reported that antioxidant selenoproteins are crucial for anti‐ferroptosis in tumors, it remains unclear whether and how ...
Shijia Bao +9 more
wiley +1 more source
Radiobiology studies of gold nanoparticle‐enhanced radiosensitization in proton therapy
Abstract Background Approximately 50%$\%$ of newly diagnosed cancer patients worldwide receive radiotherapy, most commonly with X‐rays. Proton therapy has emerged as a promising alternative, offering complementary advantages over conventional X‐rays due to its highly localized energy deposition at the Bragg peak, thereby reducing radiation exposure to ...
N. Fuster‐Martínez +13 more
wiley +1 more source
In this brief report, we propose a scenario in which bacterial volatile organic compound (BVOC)‐mediated communication with plants can be interpreted as a form of plant–microbe cooperation under heavy metal stress. Different VOCs are emitted depending on bacterial stress states, and VOCs from heavy metal‐stressed bacteria modulate plant defense ...
Anahita Barghi +2 more
wiley +1 more source
Trxr-Mimetic Alendronate-Based Carbon Dot Nanozymes For Osteoporosis Treatment
Aim or purpose: To construct alendronate carbon dot nanozyme (Se-S/ALEN CDs) with the biomimetic activity of thioredoxin reductase, and to explore its therapeutic effect on osteoporosis.
Jie Huang +4 more
doaj +1 more source
Thioredoxin system modulates metabolic and stomatal responses to elevated CO2 in Arabidopsis
Integrative model of extraplastidial NADPH‐dependent thioredoxin reductase/thioredoxin system‐mediated regulation of stomatal function, redox homeostasis, and metabolic responses under ambient and elevated CO2 in Arabidopsis thaliana. Summary The NADPH‐dependent thioredoxin reductase/thioredoxin (NTR/TRX) system plays a central role in maintaining ...
Paula da Fonseca‐Pereira +11 more
wiley +1 more source
ABSTRACT Glutathione, including reduced glutathione (GSH) and oxidized glutathione (GSSG), is the major non‐protein thiol‐based redox buffer. There are diurnal rhythms in total glutathione level and in this work, we investigate whether these oscillations might be indicative of circadian regulation of total glutathione homeostasis.
Desiré Cano‐Yelo +5 more
wiley +1 more source

