Results 91 to 100 of about 162,334 (201)

A comparative analysis of cell death signalling in RNA and DNA virus infections and potential inhibitory strategies

The FEBS Journal, EarlyView.
RNA and DNA viruses can manipulate host cell death through various mechanisms. RNA viruses (H1N1, SARS‐CoV‐2) induce acute apoptosis, necroptosis, and pyroptosis to promote rapid viral transmission and epithelial barrier damage. In contrast, DNA viruses (HSV‐1, EBV) regulate these mechanisms to sustain a lytic‐latency cycle, evade immune response and ...
Panagiotis Keramidas, Maria Pitou, Amalia Aggeli, Sotiris Varlamis, Theodora Choli‐Papadopoulou   +4 more
wiley   +1 more source

Glutathione reductase and thioredoxin reductase at the crossroad: The structure of Schistosoma mansoni thioredoxin glutathione reductase.

, 2008
Thioredoxin glutathione reductase (TGR) is a key flavoenzyme expressed by schistosomes that bridges two detoxification pathways crucial for the parasite survival in the host's organism.
BELLELLI, Andrea, Angelucci, F., Bellelli, A., Boumis, G., MIELE AE, ANGELUCCI, Francesco, DIMASTROGIOVANNI, Daniela, MIELE, Adriana Erica, BOUMIS G, DIMASTROGIOVANNI D, Brunori, M., BRUNORI, Maurizio, Dimastrogiovanni, D., BELLELLI A., BOUMIS, Giovanna, M. BRUNORI, Miele, A.E., Brunori M, Bellelli A, Angelucci F   +19 more
core   +1 more source

From isotopologues to isotopomers: advances in mass spectrometry‐based positional 13C analysis in plants

New Phytologist, EarlyView.
Workflow of gas chromatography coupled to mass spectrometry (GC‐MS)‐based 13C‐labelling analysis of plant metabolites. Summary Carbon fluxes throughout metabolic networks can be investigated experimentally through 13C‐isotope labelling experiments (13C‐ILE) and 13C‐metabolic flux analysis (13C‐MFA).
Valéria F. Lima, Jônatas G.S.B. Oliveira, Luisa Wittemeier, Joachim Kopka, Danilo M. Daloso   +4 more
wiley   +1 more source

Substitution of the Thioredoxin System for Glutathione Reductase in Drosophila melanogaster

, 2001
The disulfide reducing enzymes glutathione reductase and thioredoxin reductase are highly conserved among bacteria, fungi, worms, and mammals. These proteins maintain intracellular redox homeostasis to protect the organism from oxidative damage.
José Botella-Munoz, Katja Becker, Schneuwly, Stephan, R. Heiner Schirmer, Ulschmid, Julia K., Becker, Katja, Stefan M. Kanzok, Stephan Schneuwly, Müller, Hans-Michael, Bauer, Holger, Julia K. Ulschmid, Kanzok, Stefan M., Schirmer, R. Heiner, Anke Fechner, Botella-Munoz, José, Hans-Michael Müller, Holger Bauer, Fechner, Anke   +17 more
core   +1 more source

Effects of cold water immersion versus active recovery on oxidative stress, redox gene expression and mitochondrial adaptations after strength training

Experimental Physiology, EarlyView.
Abstract We compared the acute and chronic effects of postexercise cold water immersion (CWI) and active recovery (ACT) on oxidative stress, redox‐related gene expression, mitochondrial adaptations and muscle oxidative capacity. In a crossover study, nine males completed strength sessions, followed by either 10 min CWI or ACT.
Llion A. Roberts, Chantal A. Pileggi, Nina Zeng, Vandre C. Figueiredo, James F. Markworth, Truls Raastad, David Briskey, Katsuhiko Suzuki, Jeff S. Coombes, David Cameron‐Smith, Jonathan M. Peake   +10 more
wiley   +1 more source

Changes in redox network expression during Caco-2 cell differentiation into enterocytes

Redox Experimental Medicine
Objective: This work characterized fluctuations in cell components involved in the regulation of cell redox homeostasis during Caco-2 cell differentiation into enterocytes. Methods: Caco-2 cells were differentiated for 10 days. Gene expression of NADPH
Wei Zhu, Eleonora Cremonini, Patricia I Oteiza   +2 more
doaj   +1 more source

Correction: Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target.

, 2007
Correction: Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug ...
Angela N Kuntz, Elisabeth Davioud-Charvet, Elias S. J Arnér, Angela N Kuntz (31518), David L Williams, Jean Dessolin (31522), Lindsay L Califf, Lindsay L Califf (31521), Ahmed A Sayed, Elisabeth Davioud-Charvet (31519), David L Williams (13083), Elias S. J Arnér (31523), Ahmed A Sayed (31520), Jean Dessolin   +13 more
core   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

The Oxidized Protein Repair Enzymes Methionine Sulfoxide Reductases and Their Roles in Protecting against Oxidative Stress, in Ageing and in Regulating Protein Function

Antioxidants, 2018
Cysteine and methionine residues are the amino acids most sensitive to oxidation by reactive oxygen species. However, in contrast to other amino acids, certain cysteine and methionine oxidation products can be reduced within proteins by dedicated ...
Sofia Lourenço dos Santos, Isabelle Petropoulos, Bertrand Friguet   +2 more
doaj   +1 more source

Semisynthesis and Characterization of Mammalian Thioredoxin Reductase^†

, 2016
Thioredoxin reductase and thioredoxin constitute the cellular thioredoxin system, which provides reducing equivalents to numerous intracellular target disulfides. Mammalian thioredoxin reductase contains the rare amino acid selenocysteine.
Brian Eckenroth (2642749), Katharine Harris (2642752), Ronald T. Raines (369613), Robert J. Hondal (1306002), Anton A. Turanov (811577), Vadim N. Gladyshev (8009)   +5 more
core   +1 more source