Results 101 to 110 of about 45,317 (203)

Sultams as Dual Inhibitors of Human Carbonic Anhydrase and Thioredoxin Reductase

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
A series of sultam‐based N‐acyl derivatives with potential applications as dual TrxR1 and CA inhibitors were synthesized and evaluated. TrxR1 screening identified several active compounds, with inhibitory potency influenced by the type and orientation of substituents.
Aleksandrs Pustenko, Raitis Bobrovs, Venkatesan Saravanan, Kathir Avan, Simone Carradori, Antons Sizovs, Andrea Angeli, Claudiu T. Supuran, Raivis Žalubovskis   +8 more
wiley   +1 more source

Thioredoxin Reductase as a Target for Antibacterial Gold Compounds in Burkholderia cenocepacia: Disclosing the Molecular Basis of Enzyme Inhibition

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
The molecular basis of thioredoxin reductase inhibition by antibacterial gold(I) compounds is disclosed. X‐ray crystallography and high‐resolution ESI‐MS reveal selective gold coordination to catalytically relevant cysteine residues of Bc‐TrxR, leading to stable protein–gold adducts and disruption of enzyme redox activity.
Stefano Zineddu, José Aleixo de Azevedo‐França, Martina Aguanno, Valentina Pecchioli, Giarita Ferraro, Virginia Cuomo, Antonello Merlino, Luigi Messori   +7 more
wiley   +1 more source

The mechanism of action of auranofin analogs in B. cenocepacia revealed by chemogenomic profiling

Microbiology Spectrum
Drug repurposing efforts led to the discovery of bactericidal activity in auranofin, a gold-containing drug used to treat rheumatoid arthritis. Auranofin kills Gram-positive bacteria by inhibiting thioredoxin reductase, an enzyme that scavenges reactive ...
Dustin T. Maydaniuk, Brielle Martens, Sarah Iqbal, Andrew M. Hogan, Neil Lorente Cobo, Anna Motnenko, Dang Truong, Sajani H. Liyanage, Mingdi Yan, Gerd Prehna, Silvia T. Cardona   +10 more
doaj   +1 more source

Furagin Derivatives—Nitrofuran‐Based Hydrazones as Potential Dual Inhibitors of Thioredoxin Reductase and Carbonic Anhydrases

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Nitrofuran‐based hydrazones derived from furagin are developed as dual inhibitors of thioredoxin reductase 1 and cancer‐associated carbonic anhydrases IX and XII. The series shows selective enzyme inhibition with reduced off‐target carbonic anhydrase (CA) I/II activity, while lead compound 7g exhibits potent TrxR1 inhibition and moderate anticancer ...
Aleksandrs Pustenko, Raitis Bobrovs, Katrīna Freimane, Antons Sizovs, Andrea Angeli, Claudiu T. Supuran, Raivis Žalubovskis   +6 more
wiley   +1 more source

1,2,3-Benzoxathiazine-2,2-Dioxides as Inhibitors of Thioredoxin Reductase. [PDF]

ChemMedChem
Ivanova J, Jackeviča L, Sizovs A, Bobrovs R, Žalubovskis R.   +4 more
europepmc   +1 more source

Thioredoxin Reductase and Organometallic Complexes: A Pivotal System to Tackle Multidrug Resistant Tumors? [PDF]

Cancers (Basel), 2023
Salmain M, Gaschard M, Baroud M, Lepeltier E, Jaouen G, Passirani C, Vessières A.   +6 more
europepmc   +1 more source

Targeting Florida red tide: Curcumin inhibits Karenia brevis thioredoxin reductase. [PDF]

Plant Physiol Biochem
Taher E, Liu Y, Hondal RJ, Rein KS.
europepmc   +1 more source

Multifunctional Selenium-Sulfur-Doped Carbon Dots Nanozymes with Thioredoxin Reductase Activity for Regenerative Therapy of Infected Wounds. [PDF]

ACS Appl Mater Interfaces
Huang J, Zhou N, Cao M, Zhang X, Zhang S, Luan X, Wei X, Wang L, Zhang W, Huang Z, Shao X, Gao L, Li Y, Jin H.   +13 more
europepmc   +1 more source

Structure-based identification of a non-covalent thioredoxin reductase inhibitor with proven ADMET suitability. [PDF]

J Enzyme Inhib Med Chem
Lamanna G, Augello G, Ronga L, Tesauro D, Silvestri I, Azzolina A, Cervello M, Mangiatordi GF, Saviano M.   +8 more
europepmc   +1 more source

Calredoxin regulates the chloroplast NADPH-dependent thioredoxin reductase in Chlamydomonas reinhardtii. [PDF]

Plant Physiol, 2023
Zinzius K, Marchetti GM, Fischer R, Milrad Y, Oltmanns A, Kelterborn S, Yacoby I, Hegemann P, Scholz M, Hippler M.   +9 more
europepmc   +1 more source