The Role of the Thioredoxin System in Brain Diseases [PDF]
Antioxidants, 2022 The thioredoxin system, consisting of thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH, plays a fundamental role in the control of antioxidant defenses, cell proliferation, redox states, and apoptosis.
Geir Bjørklund +6 more
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Thioredoxin System in Insects: Uncovering the Roles of Thioredoxins and Thioredoxin Reductase beyond the Antioxidant Defences [PDF]
InsectsIncreased levels of reactive oxygen species (ROS) produced during aerobic metabolism in animals can negatively affect the intracellular redox status, cause oxidative stress and interfere with physiological processes in the cells.
Andrea Gřešková, Marek Petřivalský
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The Thioredoxin System of Mammalian Cells and Its Modulators [PDF]
Biomedicines, 2022 Oxidative stress involves the increased production and accumulation of free radicals, peroxides, and other metabolites that are collectively termed reactive oxygen species (ROS), which are produced as by-products of aerobic respiration.
Aseel Ali Hasan +3 more
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The Thioredoxin System in Edwardsiella piscicida Contributes to Oxidative Stress Tolerance, Motility, and Virulence [PDF]
Microorganisms, 2023 Edwardsiella piscicida is an important fish pathogen that causes substantial economic losses. In order to understand its pathogenic mechanism, additional new virulence factors need to be identified.
Jiaojiao He +4 more
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Mitochondrial thioredoxin system is required for enhanced stress resistance and extended longevity in long-lived mitochondrial mutants [PDF]
Redox Biology, 2022 Mild impairment of mitochondrial function has been shown to increase lifespan in genetic model organisms including worms, flies and mice. To better understand the mechanisms involved, we analyzed RNA sequencing data and found that genes involved in the ...
Namastheé Harris-Gauthier +6 more
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Evolutionarily Conserved Role of Thioredoxin Systems in Determining Longevity
Antioxidants, 2023 Thioredoxin and thioredoxin reductase are evolutionarily conserved antioxidant enzymes that protect organisms from oxidative stress. These proteins also play roles in redox signaling and can act as a redox-independent cellular chaperone.
Abdelrahman AlOkda +1 more
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Genome-Wide Thioredoxin System in Cardamine hupingshanensis: Role in Se Stress and Metabolism [PDF]
BiologyThe thioredoxin system is crucial for maintaining redox balance and stress responses in plants, but its role in selenium hyperaccumulators remains poorly understood. To our knowledge, this study is the first to perform a genome-wide identification of the
Yao Li +6 more
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Thioredoxin-dependent system. Application of inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 One of the systems responsible for maintaining cellular redox homeostasis is the thioredoxin-dependent system. An equally important function of this system is the regulation of the expression of many proteins by the transcription factor NF-κB or the ...
Anna Jastrząb, Elżbieta Skrzydlewska
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Thioredoxin system: mechanisms and therapeutic potential in mental disorders [PDF]
Frontiers in PharmacologyMental disorders, including depression, schizophrenia (SCZ), autism spectrum disorders (ASD), and substance use disorders (SUD), impose a substantial global disease burden.
Le Zhang +4 more
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Crosstalk of thioredoxin system and programmed cell death: from pathophysiology to novel therapy [PDF]
Redox BiologyThe thioredoxin (Trx) system, an integral component of cellular redox regulation, preserves protein dithiol-disulfide equilibrium through its conserved Cys-Gly-Pro-Cys active site and is involved in key cellular functions, including cell proliferation ...
Yunyi Wu +11 more
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