Results 11 to 20 of about 169,438 (276)

The thioredoxin h system: potential applications

Biotechnology Advances, 2005
The thioredoxin h system has the specific capability to reduce intramolecular disulfide bonds of proteins, thereby modifying their tertiary structure. It is involved in many processes: in the activation or deactivation of enzymes and enzyme inhibitors and in the germination process. This system can be used to improve the breadmaking quality of wheat by
Frédéric De Lamotte
exaly   +6 more sources

The Mitochondrial Thioredoxin System

Antioxidants & Redox Signaling, 2000
Eukaryotic organisms from yeast to human possess a mitochondrial thioredoxin system composed of thioredoxin and thioredoxin reductase, similar to the cytosolic thioredoxin system that exists in the same cells. Yeast and mammalian mitochondrial thioredoxins are monomers of approximately 12 kDa and contain the typical conserved active site WCGPC. However,
Miranda-Vizuete, Antonio, Damdimopoulos, Anastasios E., Spyrou, Giannis   +2 more
openaire   +4 more sources

The Mammalian Testis-Specific Thioredoxin System

Antioxidants & Redox Signaling, 2004
Redox control of cell physiology is one of the most important regulatory mechanisms in all living organisms. The thioredoxin system, composed of thioredoxin and thioredoxin reductase, has emerged as a key player in cellular redox-mediated reactions.
Miranda-Vizuete, Antonio, Sadek, Christine M., Jiménez, Alberto, Krause, William J., Sutovsky, Peter, Oko, Richard   +5 more
openaire   +4 more sources

The over expression of thioredoxin during malignancies [PDF]

Reviews in Clinical Medicine, 2014
Thioredoxin system comprised of thiorexin and NADPH dependent thiorexin reductase, is responsible for redox regulation of cells by controlling the apoptosis, proliferation and other vital processes of cells.
Shahaboddin Shabani, Navid Nourizadeh, Mohammadsaleh Soltankhah   +2 more
doaj   +4 more sources

Molecular and Cellular Responses of DNA Methylation and Thioredoxin System to Heat Stress in Meat-Type Chickens [PDF]

Animals, 2021
Heat stress (HS) causes molecular dysfunction that adversely affects chicken performance and increases mortality. The responses of chickens to HS are extremely complex.
Walid S. Habashy, Marie C. Milfort, Romdhane Rekaya, Samuel E. Aggrey   +3 more
doaj   +2 more sources

The logic of kinetic regulation in the thioredoxin system [PDF]

BMC Systems Biology, 2011
The thioredoxin system consisting of NADP(H), thioredoxin reductase and thioredoxin provides reducing equivalents to a large and diverse array of cellular processes. Despite a great deal of information on the kinetics of individual thioredoxin-dependent reactions, the kinetic regulation of this system as an integrated whole is not known.
Ché S. Pillay, Jan-Hendrik S. Hofmeyr, Johann M. Rohwer   +2 more
openaire   +5 more sources

Targeting the thioredoxin system as a novel strategy against B‐cell acute lymphoblastic leukemia [PDF]

Molecular Oncology, 2019
B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL) is a genetically heterogeneous blood cancer characterized by abnormal expansion of immature B cells.
Klaudyna Fidyt, Agata Pastorczak, Agnieszka Goral, Kacper Szczygiel, Wojciech Fendler, Angelika Muchowicz, Marcin Adam Bartlomiejczyk, Joanna Madzio, Julia Cyran, Agnieszka Graczyk‐Jarzynka, Eugene Jansen, Elzbieta Patkowska, Ewa Lech‐Maranda, Deepali Pal, Helen Blair, Anna Burdzinska, Piotr Pedzisz, Eliza Glodkowska‐Mrowka, Urszula Demkow, Karolina Gawle‐Krawczyk, Michal Matysiak, Magdalena Winiarska, Przemyslaw Juszczynski, Wojciech Mlynarski, Olaf Heidenreich, Jakub Golab, Malgorzata Firczuk   +26 more
doaj   +2 more sources

The thioredoxin system in retroviral infection and apoptosis [PDF]

Cell Death and Differentiation, 2005
Human thioredoxin (TRX) was first identified in human T-cell leukemia virus type I (HTLV-I)-positive T-cell lines and is associated with the pathophysiology of retroviral infections. TRX is a vital component of the thiol-reducing system and regulates various cellular function (redox regulation).
Hiroshi Masutani, Junji Yodoi, Ueda S
exaly   +3 more sources

Thioredoxin System Protein Expression Is Associated with Poor Clinical Outcome in Adult and Paediatric Gliomas and Medulloblastomas. [PDF]

Mol Neurobiol, 2020
The thioredoxin (Trx) system is an important enzyme family that regulates cellular redox homeostasis. Protein expression of Trx system family members has been assessed in various cancers and linked to various clinicopathological variables, disease ...
Yao A, Storr SJ, Al-Hadyan K, Rahman R, Smith S, Grundy R, Paine S, Martin SG.   +7 more
europepmc   +2 more sources

Thioredoxin System Protein Expression in Carcinomas of the Pancreas, Distal Bile Duct, and Ampulla in the United Kingdom. [PDF]

Diseases
Background: Poor survival outcomes in periampullary cancer highlight the need for improvement in biomarkers and the development of novel therapies.
Al-Hadyan KS, Storr SJ, Zaitoun AM, Lobo DN, Martin SG.   +4 more
europepmc   +2 more sources