Results 21 to 30 of about 169,438 (276)

Cross-talk between Bcr-abl and the Thioredoxin System in Chronic Myeloid Leukaemia: Implications for CML Treatment. [PDF]

Antioxidants (Basel), 2020
Chronic myeloid leukaemia (CML) is currently treated with inhibitors of the CML specific oncoprotein, bcr-abl. While this strategy is initially successful, drug resistance can become a problem.
Clapper E, Wang S, Raninga PV, Di Trapani G, Tonissen KF.   +4 more
europepmc   +2 more sources

Evolutionarily Conserved Role of Thioredoxin Systems in Determining Longevity

Antioxidants, 2023
Thioredoxin and thioredoxin reductase are evolutionarily conserved antioxidant enzymes that protect organisms from oxidative stress. These proteins also play roles in redox signaling and can act as a redox-independent cellular chaperone.
Abdelrahman AlOkda, Jeremy M. Van Raamsdonk   +1 more
doaj   +1 more source

Improved Tolerance of Lactiplantibacillus plantarum in the Presence of Acid by the Heterologous Expression of trxA from Oenococcus oeni

Fermentation, 2022
Oenococcus oeni is the main microorganism that undergoes malolactic fermentation (MLF) in the winemaking industry due to its excellent adaptability to harsh wine environments.
Longxiang Liu, Xinyu Yu, Ming Wu, Keying Zhang, Shuai Shang, Shuai Peng, Weiyu Song   +6 more
doaj   +1 more source

Cellular Responses Required for Oxidative Stress Tolerance of the Necrotrophic Fungus Alternaria alternata, Causal Agent of Pear Black Spot

Microorganisms, 2022
To establish successful infections in host plants, pathogenic fungi must sense and respond to an array of stresses, such as oxidative stress. In this study, we systematically analyzed the effects of 30 mM H2O2 treatment on reactive oxygen species (ROS ...
Miao Zhang, Yandong Zhang, Yongcai Li, Yang Bi, Renyan Mao, Yangyang Yang, Qianqian Jiang, Dov Prusky   +7 more
doaj   +1 more source

The Thioredoxin System of Helicobacter pylori [PDF]

Journal of Biological Chemistry, 2000
This paper describes the purification of thioredoxin reductase (TR) and the characterization, purification, and cloning of thioredoxin (Trx) from Helicobacter pylori. Purification, amino acid sequence analysis, and molecular cloning of the gene encoding thioredoxin revealed that it is a 12-kDa protein which possesses the conserved redox active motif ...
H J, Windle, A, Fox, D, Ní Eidhin, D, Kelleher   +3 more
openaire   +4 more sources

Transcriptional changes of proteins of the thioredoxin and glutathione systems in Acanthamoeba spp. under oxidative stress – an RNA approach

Parasite, 2022
The thioredoxin (Trx) and the glutathione (GSH) systems represent important antioxidant systems in cells and in particular thioredoxin reductase (TrxR) has been shown to constitute a promising drug target in parasites.
Köhsler Martina, Leitsch David, Loufouma Mbouaka Alvie, Wekerle Maximilian, Walochnik Julia   +4 more
doaj   +1 more source

Degradation of somatomedins by the thioredoxin system [PDF]

FEBS Letters, 1985
Insulin Degradation Thioredoxin Insulin‐like growth factor I Insulin‐like growth factor II
Enberg, Gösta, Holmgren, Arne
openaire   +2 more sources

The thioredoxin reductase system of mycoplasmas [PDF]

Microbiology, 1997
Representative species of the Mollicutes possess a thioredoxin reductase system (NTS) composed of a low-molecular-mass thioredoxin (TRX) and NADPH-binding thioredoxin reductase (NTR). The TRXs of Mycoplasma pneumoniae and M. capricolum have molecular masses of 11.2 and 12 kDa, respectively, and are stable at 90 °C for 10 min.
G, Ben-Menachem, R, Himmelreich, R, Herrmann, Y, Aharonowitz, S, Rottem   +4 more
openaire   +2 more sources

PLANT THIOREDOXIN SYSTEMS REVISITED [PDF]

Annual Review of Plant Physiology and Plant Molecular Biology, 2000
▪ Abstract  Thioredoxins, the ubiquitous small proteins with a redox active disulfide bridge, are important regulatory elements in plant metabolism. Initially recognized as regulatory proteins in the reversible light activation of key photosynthetic enzymes, they have subsequently been found in the cytoplasm and in mitochondria.
Schurmann P, Jacquot JP
openaire   +3 more sources

The role of thioredoxin reductases in brain development [PDF]

, 2008
The thioredoxin-dependent system is an essential regulator of cellular redox balance. Since oxidative stress has been linked with neurodegenerative disease, we studied the roles of thioredoxin reductases in brain using mice with nervous system (NS ...
Jonna Soerensen, Schmidt, Jörg, Soerensen, Jonna, Markus Brielmeier, Schweizer, Ulrich, Schmahl, W., Schweizer, U., Jakupoglu, Cemile, Brielmeier, Markus, Heike Beck, Schmahl, Wolfgang W., Marcus Conrad, Conrad, M., Jörg Schmidt, Brielmeier, M., Förster, Heidi, Conrad, Marcus, Förster, H., Beck, H., Wolfgang Schmahl, Beck, Heike, Jakupoglu, C., Cemile Jakupoglu, Soerensen, J., Heidi Förster, Ulrich Schweizer, Schmidt, J.   +26 more
core   +1 more source