Results 41 to 50 of about 169,438 (276)
JS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1. [PDF]
PLoS ONE, 2010 The selenoenzyme thioredoxin reductase 1 has a complex role relating to cell growth. It is induced as a component of the cellular response to potentially mutagenic oxidants, but also appears to provide growth advantages to transformed cells by inhibiting
Kornelia Edes +3 more
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Thioredoxin–thioredoxin reductase – a system that has come of age [PDF]
European Journal of Biochemistry, 2000 ‹12 000 protein having a redoxactive disulfide; thioredoxin was the name assigned to thisprotein [4]. It was shown that thioredoxin was reduced bythioredoxin reductase in a NADPH-dependent reaction and thatin its dithiol form, thioredoxin served as the reductant ofribonucleotides via a ribonucleotide reductase.
openaire +3 more sources
A Crystalline and Thermally Stable Selenocysteine Selenenic Acid
Angewandte Chemie, EarlyView.The long‐sought catalytic intermediate of selenoproteins, selenocysteine selenenic acid (Sec–SeOH), is isolated for the first time at ambient temperature. A bioinspired selenopeptide sequence encapsulated within a protective molecular cradle and an oxidant‐free route from selenenyl iodide (Sec–SeI) enable the isolation of Sec–SeOH. Contrary to the long‐
Ryosuke Masuda, Satoru Kuwano, Kei Goto
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The thioredoxin system in breast cancer cell invasion and migration. [PDF]
Redox Biol, 2016 Metastasis is the most life threatening aspect of breast cancer. It is a multi-step process involving invasion and migration of primary tumor cells with a subsequent colonization of these cells at a secondary location. The aim of the present study was to
Bhatia M +7 more
europepmc +2 more sources
Detoxification of Mitochondrial Oxidants and Apoptotic Signaling Are Facilitated by Thioredoxin-2 and Peroxiredoxin-3 during Hyperoxic Injury. [PDF]
PLoS ONE, 2017 Mitochondria play a fundamental role in the regulation of cell death during accumulation of oxidants. High concentrations of atmospheric oxygen (hyperoxia), used clinically to treat tissue hypoxia in premature newborns, is known to elicit oxidative ...
Benjamin J Forred +6 more
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Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State. [PDF]
Sci Rep, 2016 The mitochondrial thioredoxin system (NADPH, thioredoxin reductase, thioredoxin) is a major redox regulator. Here we have investigated the redox correlation between this system and the mitochondrial enzyme cyclophilin D.
Folda A +7 more
europepmc +2 more sources
Thioredoxin and Glutaredoxin Systems [PDF]
, 2019 This Special Issue features recent data concerning thioredoxins and glutaredoxins from various biological systems, including bacteria, mammals, and plants. Four of the sixteen articles are review papers that deal with the regulation of development of the effect of hydrogen peroxide and the interactions between oxidants and reductants, the description ...
Zaffagnini, Mirko, Jacquot, Jean-Pierre
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Thioredoxin and Glutathione Systems
, 2021 Most cancer cells contain high levels of reactive oxygen species (ROS), which result in higher expression levels of the glutathione and thioredoxin reductase systems. These antioxidant systems convert ROS to nonharmful compounds and they also reduce disulfide bonds in oxidized proteins.
Yu, Yezhou +2 more
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Cloning of thioredoxin h reductase and characterization of the thioredoxin reductase–thioredoxin h system from wheat [PDF]
Biochemical Journal, 2002 Thioredoxins h are ubiquitous proteins reduced by NADPH— thioredoxin reductase (NTR). They are able to reduce disulphides in target proteins. In monocots, thioredoxins h accumulate at high level in seeds and show a predominant localization in the nucleus of seed cells.
Pérez Ruiz, Juan Manuel +2 more
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CellsChronic exposure to arsenic via drinking water can induce bladder cancer in humans. Nevertheless, there is little knowledge about the precise mechanisms of this.
Xiangli Yan +3 more
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