Results 61 to 70 of about 169,438 (276)
Characterization of the Thioredoxin System from Colwellia psychrerythraea and Thermosipho africanus [PDF]
, 2021 The thioredoxin system is a ubiquitous oxidoreductase system that consists of the enzyme thioredoxin reductase, the protein thioredoxin and the cofactor nicotinamide adenine dinucleotide phosphate.
Sahtout, Naheda Mohamad Fayez
core
, 2021 Chronic myeloid leukemia (CML) is a myeloproliferative disorder that is caused by the formation of a fusion onco-protein, BCR-ABL. Since BCR-ABL plays a role in the progression of CML, the most common treatments of CML are tyrosine kinase inhibitors ...
Di Trapani, Giovanna +5 more
core +1 more source
Thioredoxin Inhibitors Attenuate Platelet Function and Thrombus Formation.
PLoS ONE, 2016 Thioredoxin (Trx) is an oxidoreductase with important physiological function. Imbalances in the NADPH/thioredoxin reductase/thioredoxin system are associated with a number of pathologies, particularly cancer, and a number of clinical trials for ...
Clive Metcalfe +5 more
doaj +1 more source
Antioxidants, 2023 Geranylgeranylacetone (GGA) exerts cytoprotective activity against various toxic stressors via the thioredoxin (TRX) redox system; however, its effect on skin inflammation and molecular mechanism on inducing the TRX of GGA is still unknown.
Tiancheng Jin +10 more
doaj +1 more source
The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding
Animal Research and One Health, EarlyView.A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang +10 more
wiley +1 more source
The Emerging Role of the Thioredoxin System in Angiogenesis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2010 Although there have been a multitude of studies, the mechanisms of angiogenesis remain incompletely understood. Increasing evidence suggests that cellular redox homeostasis is an important regulator of angiogenesis. The thioredoxin (TRX) system functions as an endogenous antioxidant that can exert influence over endothelial cell function ...
Louise L, Dunn +3 more
openaire +2 more sources
, 2019 The Gram-negative pathogen, Acinetobacter baumannii has emerged as a global nosocomial health threat affecting the majority of hospitals in the U.S. and abroad.
Bernard P. Arulanandam (225852) +15 more
core +1 more source
Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy
BMEMat, EarlyView.This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma +9 more
wiley +1 more source
Nature Communications, 2018 Thioredoxin (Trx), Trx reductase, Txnip and NADPH together comprise the Trx system. Here the authors make a T cell-specific thioredoxin reductase-1 knockout mouse to show how this system reprograms cellular metabolism to enable T cell development ...
Jonathan Muri +9 more
doaj +1 more source
Thioredoxin and glutathione systems differ in parasitic and free-living platyhelminths
BMC Genomics, 2010 Background The thioredoxin and/or glutathione pathways occur in all organisms. They provide electrons for deoxyribonucleotide synthesis, function as antioxidant defenses, in detoxification, Fe/S biogenesis and participate in a variety of cellular ...
Salinas Gustavo +5 more
doaj +1 more source