Results 81 to 90 of about 162,334 (201)

Identification of proteins targeted by the thioredoxin superfamily in Plasmodium falciparum. [PDF]

, 2009
The malarial parasite Plasmodium falciparum possesses a functional thioredoxin and glutathione system comprising the dithiol-containing redox proteins thioredoxin (Trx) and glutaredoxin (Grx), as well as plasmoredoxin (Plrx), which is exclusively found ...
Sturm, Nicole, Becker Katja, Koncarevic, Sasa, Forchhammer, Karl, Mailu, Boniface M., Rahlfs, Stefan, Katja Becker, Deponte, Marcel, Koncarevic Sasa, Becker, Katja, Sturm Nicole, Mailu Boniface M., Marcel Deponte, Deponte Marcel, Jortzik, Esther, Stefan Rahlfs, Jortzik Esther, Esther Jortzik, Karl Forchhammer, Nicole Sturm, Forchhammer Karl, Boniface M Mailu, Sasa Koncarevic, Rahlfs Stefan   +23 more
core   +2 more sources

High Specificity of sIgE to α−/β‐Gliadin and Limited Reactivity to Non‐Gluten Proteins in Wheat Allergy Dependent on Augmentation Factors (WALDA)

Clinical &Experimental Allergy, EarlyView.
This study suggest that WALDA is characterized by highly specific reactivity to gliadin proteins, with limited sensitization to non‐gluten wheat components. sIgE to α‐/β‐gliadin represents a promising diagnostic biomarker with superior specificity compared to ω5‐gliadin alone.
Valentina Faihs, Florian Schusta, Claudia Kugler, Tilo Biedermann, Monika Raulf, Margitta Worm, Knut Brockow, Ingrid Sander   +7 more
wiley   +1 more source

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

The FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source

Energetic dysregulations in psychotic disorders: Targets for new therapeutics

The FEBS Journal, EarlyView.
The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson, Kai‐Christian Sonntag, Thao Do Vy Le, Kaitlin Shannon, Chao Wang, Fei Du, Xi Chen, Donna McPhie, Dost Ongur, Bruce Cohen, Virginie‐Anne Chouinard   +10 more
wiley   +1 more source

New Inhibitors of the Thioredoxin-Thioredoxin Reductase System Based on a Naphthoquinone Spiroketal Natural Product Lead.

, 2001
Natural products of the naphthoquinone spiroketal structural type served as lead structures for the development of novel inhibitors of the thioredoxin-thioredoxin reductase redox system.
Jung, J K, Wipf, Peter, Hopkins, T D, Southwick, E C, Rodriguez, S, Birmingham, A, Lazo, J S, Powis, G   +7 more
core  

Ferredoxin-thioredoxin Reductase: Purification and Substrate Requirements

, 1984
International audienceIn the recent years, three systems capable of promoting the light activation of enzymes in higher plant chloroplasts have been described (Anderson, 1979; Buchanan, 1980).
Gadal, Pierre, Jean-Pierre Jacquot, Michel Droux, Suzuki, Akira, Akira Suzuki, Droux, Michel, Jacquot, Jean-Pierre, Pierre Gadal   +7 more
core   +1 more source

Hepatocytes lacking thioredoxin reductase 1 have normal replicative potential during development and regeneration [PDF]

, 2010
Cells require ribonucleotide reductase (RNR) activity for DNA replication. In bacteria, electrons can flow from NADPH to RNR by either a thioredoxin-reductase- or a glutathione-reductase-dependent route.
Jean A. Kundert, Kundert, Jean A, Dana M. van der Heide, Elena S. Suvorova, Carla M. Weisend, Rollins, MaryClare F, Merrill, Gary F, van der Heide, Dana M, Mario R. Capecchi, Schmidt, Edward E, Kristin M. Comstock, Suvorova, Elena S, Edward E. Schmidt, Comstock, Kristin M, Capecchi, Mario R, MaryClare F. Rollins, Gary F. Merrill, Weisend, Carla M   +17 more
core   +1 more source

A comprehensive study on ferredoxin isoforms in the cyanobacterium Synechocystis sp. PCC 6803

The FEBS Journal, EarlyView.
Ferredoxins are small FeS cluster‐containing proteins that play a central role in distributing electrons within the cell. The cyanobacterium Synechocystis sp. PCC 6803 contains several ferredoxin isoforms and their biophysical properties (UV/Vis and EPR spectra, Em potential), expression patterns, and interactions with the electron donors photosystem I
Marko Boehm, Drazenka Svedruzic, Carolyn E. Lubner, Jens Appel, David W. Mulder, Effie C. Kisgeropoulos, Vanessa Hueren, Katharina Spengler, Vivek S. Bharadwaj, Zhanjun Guo, Anastasia E. Ledinina, Darja Deobald, Lorenz Adrian, Paul W. King, Kirstin Gutekunst   +14 more
wiley   +1 more source

The Human Thioredoxin System: Modifications and Clinical Applications [PDF]

Iranian Journal of Basic Medical Sciences, 2011
The thioredoxin system, comprising thioredoxin (Trx), thioredoxin reductase (TrxR) and NADPH, is one of the major cellular antioxidant systems, implicated in a large and growing number of biological functions.
Seyed Isaac Hashemy
doaj  

Purification of mitochondrial thioredoxin reductase and its involvement in the redox regulation of membrane permeability [PDF]

, 1998
The isolation to purity of a rat liver mitochondrial thioredoxin reductase is reported. The mitochondrial enzyme shows a chromatographic behavior different from that of the cytosolic enzyme. The purified enzyme, after sodium dodecylsulfate-polyacrylamide
RIGOBELLO, MARIA PIA, BARZON E, CALLEGARO MT, BINDOLI, ALBERTO, BENETTI M, Elena Barzon, Alberto Bindoli, Maria Teresa Callegaro, Maria Pia Rigobello, Monica Benetti   +9 more
core   +1 more source