Results 111 to 120 of about 162,334 (201)

Spatiotemporal Dynamics of Cytosolic NADPH in Living Arabidopsis thaliana

Plant, Cell &Environment, Volume 49, Issue 11, Page 9101-9116, November 2026.
ABSTRACT In plants, an adequate supply of Nicotinamide adenine dinucleotide phosphate (NADPH) in the cytosol is crucial for maintaining a variety of biosynthetic and antioxidant reactions. Cytosolic NADPH is mainly generated via four enzymatic pathways: NADP‐dependent malic dehydrogenase (NADP‐ME), cytosolic oxidative pentose phosphate pathway (cOPPP),
Danying Lu, Jinhong Liu, Shey‐Li Lim, Jia Yi Zhong, Boon Leong Lim   +4 more
wiley   +1 more source

Natural Product‐Induced Ferroptosis to Overcome Therapy Resistance in Aggressive Cancers

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Natural products trigger ferroptosis through iron overload, glutathione depletion, glutathione peroxidase 4 inhibition, and reactive oxygen species accumulation, selectively targeting aggressive, and drug‐resistant cancers. Polyphenols, alkaloids and terpenoids emerge as promising multi‐target agents to overcome therapy resistance and improve future ...
Giorgio Antoniolli
wiley   +1 more source

Interplay Between Epigenetics and Reactive Oxygen Species in Tumor Radioresistance: Mechanisms and Therapeutic Strategies for Radiotherapy

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Radiotherapy efficacy is constrained by tumor radioresistance, which arises in part from the interplay between reactive oxygen species (ROS) and epigenetic regulation. This review systematically synthesizes the bidirectional “epigenetics‐ROS interactive network” that governs tumor radiosensitivity. We propose that this network operates through
Zhengmao Yang, Jiaxin Wang, Guofang Wang, Jiamin Zhu, Shengnan Zhang, Wenjian Guo   +5 more
wiley   +1 more source

Chemical Diversity and Biological Significance of Sesquiterpene Lactones: From Biosynthesis to Anticancer Mechanisms

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Sesquiterpene lactones emerge as structurally diverse anticancer scaffolds with multifaceted mechanisms of action. Their biosynthesis, chemical diversity, structure–activity relationships, semisynthetic diversification, and molecular targets are integrated to highlight therapeutic opportunities and challenges.
Kedar Nimba Chaudhari, Ragini Yadav, Mayank Kashyap, Shreyans K. Jain   +3 more
wiley   +1 more source

Thioredoxin Reduces the Thiosulfonate Enzyme-Intermediate

, 2013
ESI mass spectra, in low resolution, of 10 μM APS reductase (A); 2.5 μM APS and 10 μM APS reductase (B); 2.5 μM APS, 3.7 μM oxidized thioredoxin, and 10 μM APS reductase (C); and 2.5 μM APS, 3.7 μM thioredoxin reduced with 33 μM DTT, and 10 μM APS ...
Kate S Carroll (275071), Hong Gao (68166), Huiyi Chen (92246), Carolyn R Bertozzi (1160), Julie A Leary (275072), C. David Stout (213073)   +5 more
core   +1 more source

Dietary Selenium and β‐Carotene Contribute to the Inverse Association Between Antioxidant Mixtures and Stroke: Evidence From NHANES Using Mixture Models and Machine Learning

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
In this NHANES study of 37,746 participants, we examined the joint association of six dietary antioxidant‐related nutrients (vitamins A, C, and E, β‐carotene, selenium, and zinc) with stroke, applying 1:1 propensity score matching (matched sub‐cohort, n = 2750), mixture models (WQS, qgcomp, and BKMR), and machine learning with SHAP interpretation ...
Aifang Zhong, Xinmin Deng, Yejun Tan, Rui Lai, Xiaofeng Lv, Xia Zhou, Jiaying Zhu   +6 more
wiley   +1 more source

Trxr-Mimetic Alendronate-Based Carbon Dot Nanozymes For Osteoporosis Treatment

International Dental Journal
Aim or purpose: To construct alendronate carbon dot nanozyme (Se-S/ALEN CDs) with the biomimetic activity of thioredoxin reductase, and to explore its therapeutic effect on osteoporosis.
Jie Huang, Han Jin, Licheng Wang, Mengmeng Cao, Na Zhou   +4 more
doaj   +1 more source

Postbiotics Unveiled: The Next Emerging Trend in Functional Foods

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
The graphical abstract shows different postbiotic production techniques, such as sonication, fermentation, heat inactivation, high‐pressure processing, dehydration, pH modification, and omic technologies. Additionally, it highlights the emerging health benefits and applications of postbiotics, including immune modulation, gut–brain axis regulation ...
Zoha Wahid, Abdul Momin Rizwan Ahmad, Farheen Zulfiqar, Syed Hassan Bin Usman Shah, Nilab Mohammadi   +4 more
wiley   +1 more source

The diversity and evolution of thioredoxin reductase: new perspectives

The thioredoxin system is a major line of cellular defence against oxygen damage. Two distinct thioredoxin reductases found in eukaryotes have different catalytic mechanisms and a mutually exclusive distribution reflecting a complex evolutionary history.
Embley TM; Hirt RP; Muller S; Coombs GH
core   +2 more sources

Dietary Soybean and Kappaphycus sp. Differentially Modulate Gut Microbiota Diversity and Predicted Functional Profile in Nile Tilapia (Oreochromis niloticus)

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Soybean meal and Kappaphycus sp. diets reshaped gut microbiota diversity, taxonomic composition, and predicted metabolic functions in Nile tilapia while maintaining a stable core microbiota. These findings highlight gut microbial responses as a useful indicator for evaluating sustainable alternative feed ingredients in aquaculture.
Leonildo dos Anjo Viagem, Jean Nepomuscene Hakizimana, Cyrus Rumisha, Brunno da Silva Cerozi, Gerald Misinzo   +4 more
wiley   +1 more source