Results 111 to 120 of about 49,631 (209)

Substitution of the Thioredoxin System for Glutathione Reductase in Drosophila melanogaster

, 2001
The disulfide reducing enzymes glutathione reductase and thioredoxin reductase are highly conserved among bacteria, fungi, worms, and mammals. These proteins maintain intracellular redox homeostasis to protect the organism from oxidative damage.
José Botella-Munoz, Katja Becker, Schneuwly, Stephan, R. Heiner Schirmer, Ulschmid, Julia K., Becker, Katja, Stefan M. Kanzok, Stephan Schneuwly, Müller, Hans-Michael, Bauer, Holger, Julia K. Ulschmid, Kanzok, Stefan M., Schirmer, R. Heiner, Anke Fechner, Botella-Munoz, José, Hans-Michael Müller, Holger Bauer, Fechner, Anke   +17 more
core   +1 more source

Vacuolization as a Novel Approach to Cancer Therapy

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak, Noor Hussein, Veronica Piedra, Saloni Malla, Chandrabose Karthikeyan, Haneen Amawi, Harish Rajak, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +9 more
wiley   +1 more source

Trxr-Mimetic Alendronate-Based Carbon Dot Nanozymes For Osteoporosis Treatment

International Dental Journal
Aim or purpose: To construct alendronate carbon dot nanozyme (Se-S/ALEN CDs) with the biomimetic activity of thioredoxin reductase, and to explore its therapeutic effect on osteoporosis.
Jie Huang, Han Jin, Licheng Wang, Mengmeng Cao, Na Zhou   +4 more
doaj   +1 more source

Thioredoxin reductase and its inhibitors.

, 2014
Thioredoxin plays a crucial role in a wide number of physiological processes, which span from reduction of nucleotides to deoxyriboucleotides to the detoxification from xenobiotics, oxidants and radicals.
DESIATO, GIANNI, SACCOCCIA, FULVIO, Fulvio Saccoccia, BELLELLI, Andrea, Giovanna Boumis, Andrea Bellelli, Gianni Desiato, ANGELUCCI, Francesco, Adriana Erica Miele, MIELE, Adriana Erica, Daniela Carotti, CAROTTI, Daniela, BOUMIS, Giovanna   +12 more
core   +1 more source

Acetate‐Linked Energy Metabolism as a Determinant of Early Haemophilus influenzae Infection Fitness

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The Pta–AckA pathway is critical for Haemophilus influenzae energy generation, metabolic homeostasis, stress resistance, and intracellular colonization, highlighting its potential as a target for management of H. influenzae infections.
Marufa Nasreen, Jennifer Hosmer, Saurab Kishore Munshi, Riya Joshi, Ayaho Yamamoto, Horst J. Schirra, Peter Sly, Alastair G. McEwan, Ulrike Kappler   +8 more
wiley   +1 more source

Thioredoxin Reductase (TR) Activity in TR siRNA-treated FaDu cells.

, 2013
Thioredoxin Reductase (TR) Activity in TR siRNA-treated FaDu cells.
Douglas R. Spitz (10597), Elise V. M. Fletcher (300952), Sean M. Martin (300953), Andrean L. Simons (300955), C. Michael Knudson (89096), Arya Sobhakumari (300950), Laurie Love-Homan (300951), Arlene D. Parsons (300954)   +7 more
core   +1 more source

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

Conformational fluctuations coupled to the thiol-disulfide transfer between thioredoxin and arsenate reductase in Bacillus subtilis

, 2007
Arsenic compounds commonly exist in nature and are toxic to nearly all kinds of life forms, which directed the evolution of enzymes in many organisms for arsenic detoxification.
Hu, Yunfei, Xia, Bin, Jin, Changwen, Xu, Huimin, Zhang, Xinxin, Lescop, Ewen, Li, You   +6 more
core   +1 more source

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source