Results 121 to 130 of about 162,334 (201)

The mechanism of action of auranofin analogs in B. cenocepacia revealed by chemogenomic profiling

Microbiology Spectrum
Drug repurposing efforts led to the discovery of bactericidal activity in auranofin, a gold-containing drug used to treat rheumatoid arthritis. Auranofin kills Gram-positive bacteria by inhibiting thioredoxin reductase, an enzyme that scavenges reactive ...
Dustin T. Maydaniuk, Brielle Martens, Sarah Iqbal, Andrew M. Hogan, Neil Lorente Cobo, Anna Motnenko, Dang Truong, Sajani H. Liyanage, Mingdi Yan, Gerd Prehna, Silvia T. Cardona   +10 more
doaj   +1 more source

Thioredoxin/thioredoxin reductase system involvement in cerebellar granule cell apoptosis

, 2014
The involvement of thioredoxin/thioredoxin reductase system has been investigated in cerebellar granule cells (CGCs), a cellular system in which neurons are induced in apoptosis by the physiological stimulus of lowering extracellular potassium ...
CASALINO, Elisabetta, A. Atlante, V. A. Petragallo, A. Bobba, Petragallo VA, Atlante A, Bobba A, Casalino E   +7 more
core   +1 more source

Ischemic Stroke and Traumatic Brain Injury: Epidemiology, Molecular Pathways, and Emerging Therapies

MedComm, Volume 7, Issue 10, October 2026.
Schematic overview of secondary brain injury after ischemic stroke and traumatic brain injury. Both conditions trigger endothelial cell dysfunction, pericyte contraction, and upregulated AQP4 expression in astrocytic end‐feet, leading to blood–brain barrier disruption.
Mengzhao Feng, Qi Qin, Fang Wang, Kaiyuan Zhang, Zhihua Li, Junlei Chang, Min Yu, Fuyou Guo   +7 more
wiley   +1 more source

Synthesis and Cytotoxic Activity of 1,3‐Selenazole‐2‐Amine Derivatives With Computational ADMET Profiling

ChemistryOpen, Volume 15, Issue 10, October 2026.
Four novel 1,3‐selenazole‐2‐amine derivatives were synthesized and evaluated in HT‐29, MCF‐7, and L929 cell lines. Compound 4 showed the highest MCF‐7 cytotoxicity. Compound 3 displayed low L929 toxicity. In silico ADMET predicted favorable pharmacokinetic properties.
Gulay Dilek, Senem Akkoc
wiley   +1 more source

Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome

, 2007
Thioredoxin reductases (Txnrd) maintain intracellular redox homeostasis in most organisms. Metazoan Txnrds also participate in signal transduction.
Bondareva, Alla A, Prigge, Justin R, Capecchi, Mario R, Merrill, Gary F, Wallin, Stephanie L, Li, Yan, Lopez, Nathan I, Iverson, Sonya V, Lucas, Olivier, Schmidt, Edward E, Wakamiya, Maki, Siders, Ashley M   +11 more
core   +1 more source

Application of Omics Technologies for Cowpea Improvement

Plant-Environment Interactions, Volume 7, Issue 5, October 2026.
ABSTRACT Cowpea (Vigna unguiculata) is a vital crop for food security, nutrition, and climate resilience in sub‐Saharan African and other semi‐arid regions. However, its improvement is constrained by the complexity of polygenic traits such as drought tolerance, pest resistance, and seed quality.
Junior S. Kamara, Festus O. Olasupo, Abdoul‐Razak Oumarou Mahamane, Katleho S. Selele   +3 more
wiley   +1 more source

Bacterial Contribution to Hydrogen Peroxide Decomposition in Lake Erie Cyanobacterial Harmful Algal Bloom Communities Is Dependent on Bloom Stage

Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.
A seasonal time series metatranscriptome dataset suggests that neutralising hydrogen peroxide in Microcystis blooms requires a complex division of labour that is further complicated by seasonality and bloom development. ABSTRACT Cyanobacterial harmful algal blooms (cHABs) are expanding globally and often involve toxin‐producing species such as ...
Chelsea E. Donovan, Gabriel Padilla, Madison Ashbaugh, Sophie Bencivenga, Jordan Cibellis, Wilson Ritterpusch, Cameron Tierney, Justin D. Chaffin, Louie L. Wurch, Morgan M. Steffen   +9 more
wiley   +1 more source

The architecture of redox microdomains: Cascading gradients and peroxiredoxins’ redox-oligomeric coupling integrate redox signaling and antioxidant protection

Redox Biology
In the cytosol of human cells under low oxidative loads, hydrogen peroxide is confined to microdomains around its supply sites, due to its fast consumption by peroxiredoxins.
Matthew Griffith, Adérito Araújo, Rui Travasso, Armindo Salvador   +3 more
doaj   +1 more source

Transcriptomic and proteomic signatures underlying nymphal adaptation and foam production in the forage pest Mahanarva spectabilis

Insect Molecular Biology, Volume 35, Issue 5, Page 556-575, October 2026.
RNA‐seq and Batelli gland proteomics of fifth‐instar Mahanarva spectabilis nymphs reveal transcripts and proteins associated with xylem feeding, foam production and environmental interaction. Functional annotation identified genes involved in osmoregulation, detoxification, chemosensation and stress responses, while proteomic analysis confirmed ...
Monique da Silva Bonjour, Angelo José Rinaldi, Eulálio Gutemberg Dias dos Santos, Gabriely Teixeira Bhering Faria, Ana Márcia Escocard de Azevedo Manhães, Jorge Fernando Pereira, Alexander Machado Auad, Maria Goreti de Almeida Oliveira, Humberto Josué de Oliveira Ramos   +8 more
wiley   +1 more source

Plasticity of metabolism in plants

The Plant Journal, Volume 128, Issue 1, October 2026.
SUMMARY The ability of plants to reprogram their metabolism in response to fluctuating environments, referred to as metabolic plasticity, is a key feature that enables sessile organisms to maintain growth, survival, and reproduction under changing conditions.
Xufeng Chen, Yinan Ouyang, Ashwin Ananthanarayanan, Dhanush S. Srikanthan, Chibueze K. Ene, Arsalan Khan, Joerg Fettke, Mustafa Bulut, Zoran Nikoloski, Sandra Marcela Correa, Alisdair R. Fernie   +10 more
wiley   +1 more source