Results 121 to 130 of about 49,631 (209)

The mechanism of action of auranofin analogs in B. cenocepacia revealed by chemogenomic profiling

Microbiology Spectrum
Drug repurposing efforts led to the discovery of bactericidal activity in auranofin, a gold-containing drug used to treat rheumatoid arthritis. Auranofin kills Gram-positive bacteria by inhibiting thioredoxin reductase, an enzyme that scavenges reactive ...
Dustin T. Maydaniuk, Brielle Martens, Sarah Iqbal, Andrew M. Hogan, Neil Lorente Cobo, Anna Motnenko, Dang Truong, Sajani H. Liyanage, Mingdi Yan, Gerd Prehna, Silvia T. Cardona   +10 more
doaj   +1 more source

Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi, Xi Liu, Xi Zhang, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

Thioredoxin System Protein Expression in Carcinomas of the Pancreas, Distal Bile Duct, and Ampulla in the United Kingdom

Background: Poor survival outcomes in periampullary cancer highlight the need for improvement in biomarkers and the development of novel therapies.
Abed M. Zaitoun, Khaled S. Al-Hadyan, Lobo, Dileep N., Martin, Stewart G., Zaitoun, Abed M., Al-Hadyan, Khaled S., Dileep N. Lobo, Sarah J. Storr, Storr, Sarah J., Stewart G. Martin   +9 more
core   +1 more source

Harnessing Trace Elements: Novel Radiosensitization Strategies for Enhanced Cancer Radiotherapy

Rare Metals, Volume 45, Issue 6, June 2026.
ABSTRACT Radiotherapy (RT) is one of the core methods of comprehensive cancer treatment. Globally, more than 40% of cancer patients rely on radiotherapy to achieve tumor control, cure or palliative relief. However, radiation resistance, immunosuppression and normal tissue injury limit its clinical application.
Yuhuan Zhang, Yizhi Ge, Hongguang Xiang, Ji Liu, Yu Tian, Yan Shen, Dan Zong   +6 more
wiley   +1 more source

Exploring conformational dynamics of flavoenzymes with flavin fluorescence relaxation spectroscopy

, 2002
Research described in this thesis was aimed at gaining more insight into the active-site dynamics of dimeric flavoproteins by means of fluorescence relaxation spectroscopy.
Berg, P.A.W., van den, van den Berg, P.A.W.   +1 more
core  

Monoclonal Antibodies to Human Thioredoxin Reductase

, 1998
The thioredoxin system consisting of thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH is an electron donor for ribonucleotide reductase but has also been implicated in other cellular events, including secretion, growth promotion, regulation of ...
Holmgren, A,, Söderberg, A, Sahaf, B, Rosén, A, Söderberg, Anita,, Sahaf, Bita,, Holmgren, Arne,, Rosén, Anders,   +7 more
core   +1 more source

Microbial Electrosynthesis Reshapes Energy Metabolism and Physiology in Clostridium ljungdahlii

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
Microbial electrosynthesis drives Clostridium ljungdahlii into a distinct stress‐associated physiological state, different from gas fermentation. Comparative multi‐omics and electron microscopy reveal physiological constraints that help explain the poor performance of MES.
Sara Al Sbei, Santiago T. Boto, Thomas Krüger, Kai Papenfort, Martin Westermann, Aurélie Jost, Falk Harnisch, Axel A. Brakhage, Miriam A. Rosenbaum   +8 more
wiley   +1 more source

Effect of Metal Cations on Selenite Bioreduction by a Consortium of Halophilic/Halotolerant Bacteria and/or Yeast

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
Evaluation the effects of potentially toxic co‐contaminating metal cations, including cadmium (Cd), lead (Pb), and Zinc (Zn), on the bioreduction of selenite by a consortium of halotolerant and halophilic bacteria and/or yeast. ABSTRACT Selenium oxyanion pollution in the environment, often originating from anthropogenic industrial activities, causes ...
Elham Lashani, Hamid Moghimi, Raymond J. Turner, Mohammad Ali Amoozegar   +3 more
wiley   +1 more source

The Seasonal and Spatial Patterns of Planktonic Bacterial and Fungal Community Structure and the Response to Environmental Factors in the Danjiangkou Reservoir, China

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
This study investigated the spatial and temporal distribution patterns of bacterial and fungal communities in the Danjiangkou Reservoir during dry season and wet season, revealing the mechanism by which seasonal variations drive changes in microbial community composition and function through their influence on the physicochemical properties of the ...
Yarui Cheng, Xiaoyu Lu, Zunwei Ke, Lu Gan, Yaqing Zhou, Fengjian Wang   +5 more
wiley   +1 more source