Results 41 to 50 of about 4,141 (163)

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Auranofin is active against Histoplasma capsulatum and reduces the expression of virulence-related genes.

PLoS Neglected Tropical Diseases
BackgroundAuranofin is an approved anti-rheumatic drug that has a broad-range inhibitory action against several microorganisms, including human pathogenic fungi.
Marcos de Abreu Almeida, Lilian Cristiane Baeza, Leandro B R Silva, Andréa Reis Bernardes-Engemann, Fernando Almeida-Silva, Rowena Alves Coelho, Iara Bastos de Andrade, Dario Corrêa-Junior, Susana Frases, Rosely Maria Zancopé-Oliveira, Alexandre Alanio, Carlos Pelleschi Taborda, Rodrigo Almeida-Paes   +12 more
doaj   +1 more source

Auranofin Releasing Antibacterial and Antibiofilm Polyurethane Intravascular Catheter Coatings

Frontiers in Cellular and Infection Microbiology, 2019
Intravascular catheter related bloodstream infections (CRBSIs) are a leading cause of hospital-acquired infections worldwide, resulting not only in the burden of cost and morbidity for patients but also in the over-consumption of medical resources for ...
Hanyang Liu, Shashank Shukla, Noel Vera-González, Nagendran Tharmalingam, Eleftherios Mylonakis, Beth Burgwyn Fuchs, Anita Shukla   +6 more
doaj   +1 more source

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 554-567, September 2026.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source

Comparison of the mechanism of antimicrobial action of the gold(I) compound auranofin in Gram-positive and Gram-negative bacteria

Microbiology Spectrum
While highly effective at killing Gram-positive bacteria, auranofin lacks significant activity against Gram-negative species for reasons that largely remain unclear.
Laísa Quadros Barsé, Agnes Ulfig, Marharyta Varatnitskaya, Melissa Vázquez-Hernández, Jihyun Yoo, Astrid M. Imann, Natalie Lupilov, Marina Fischer, Katja Becker, Julia E. Bandow, Lars I. Leichert   +10 more
doaj   +1 more source

Proline‐Derived N‐Heterocyclic Carbene Gold(I) Complexes With Dual DNA Binding and Thioredoxin Reductase Inhibition

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Proline‐derived Au(I)–NHC complexes display potent anticancer activity against lung and triple‐negative breast cancer cells. The cationic complexes promote DNA intercalation, thioredoxin reductase inhibition, ROS overproduction, and mitochondrial membrane depolarization, ultimately triggering apoptotic cell death through a multimodal mechanism of ...
Giacomo Cassarà, María Gil‐Moles, Thomas Scattolin, M. Concepción Gimeno   +3 more
wiley   +1 more source

Chlorogenic Acid Supplementation Benefits Zebrafish Embryos Exposed to Auranofin

Pharmaceutics, 2020
Antioxidant supplementation may potentially be beneficial for embryonic development to reduce complications associated with increased levels of oxidative stress. Chlorogenic acid, one of the key polyphenolic antioxidants in S.
Jasper Z. S. Chiu, Isabella Hold, Trent A. C. Newman, Julia A. Horsfield, Arlene McDowell   +4 more
doaj   +1 more source

Repurposing non-antifungal drugs auranofin and pentamidine in combination as fungistatic antifungal agents against C. albicans

Frontiers in Cellular and Infection Microbiology, 2022
Fungal infection is a serious global health issue, causing approximately 1.5 million mortalities annually. However, clinically available anti-fungal drugs are limited, especially for multidrug-resistant fungal infections.
Jiaying Lin, Xueyi Xiao, Yijing Liang, Huimin Zhao, Yingxiao Yu, Peiyan Yuan, Sha Lu, Xin Ding   +7 more
doaj   +1 more source

Overcoming Radiation Resistance: Ferroptosis Induction to Sensitize Solid Tumors to Radiation Therapy

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Radiation therapy (RT) is a mainstay of treatment for a myriad of cancers, often utilized for tumors that are unable to be resected, as well as an adjunct to surgery and chemotherapy. Unfortunately, many cancers are resistant to RT‐induced damage and subsequent cell death.
Joseph Carmicheal, Caden M. Fritson, Alexandra Seas, Heidi Vieira, Surinder K. Batra   +4 more
wiley   +1 more source

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

MedComm, Volume 7, Issue 8, August 2026.
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang, Ying Liu, Yilin Hou, Hongxia Niu   +3 more
wiley   +1 more source