Results 41 to 50 of about 5,328 (197)
Auranofin coated catheters inhibit bacterial and fungal biofilms in a murine subcutaneous model
Frontiers in Cellular and Infection Microbiology, 2023 Microbe entry through catheter ports can lead to biofilm accumulation and complications from catheter-related bloodstream infection and ultimately require antimicrobial treatment and catheter replacement.
LewisOscar Felix +7 more
doaj +1 more source
Die Wirkungsweise des Auranofin in Giardia lamblia
, 2023 In den letzten Jahrzehnten hat sich die Behandlung der durch Giardia lamblia ausgelösten Giardiasis kaum gewandelt. Es waren und sind hierbei vorwiegend Metronidazol und Albendazol als Mittel der Wahl etabliert.
Tyll, Dominik
core
Cyclic Voltammetry of Auranofin [PDF]
Metal-Based Drugs, 1999 The oxidative behavior of Auranofin, 2,3,4,6‐tetra‐O‐acetyl‐1‐thio‐β ‐D‐glucopyranosato‐ S(triethylphosphine)gold(I), was investigated by using cyclic voltammetry (CV) in 0.1 M Bu4NPF6/CH2Cl2 and 0.1 M Bu4NPF4/CH2Cl2 solutions using Pt working and auxiliary electrodes and a Ag/AgCI reference.
Mohamed, Ahmed A. +2 more
openaire +2 more sources
Comprehensive chemical proteomics for target deconvolution of the redox active drug auranofin
Redox Biology, 2020 Chemical proteomics encompasses novel drug target deconvolution methods in which compound modification is not required. Herein we use Thermal Proteome Profiling, Functional Identification of Target by Expression Proteomics and multiplexed redox ...
Amir Ata Saei +8 more
doaj +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Gold has been used for centuries in both ornamental and medicinal contexts. More recently, gold compounds, containing ions or nanoparticles, have attracted attention for their anti‐inflammatory, anticancer, and diagnostic applications. Therefore, concerns about systemic toxicity and biodistribution have prompted investigations into the ...
Samira Maghraoui +2 more
wiley +1 more source
AntioxidantsGlioblastoma (GBM) is an incurable primary brain cancer characterized by increased reactive oxygen species (ROS) production. The redox-sensitive tumor suppressor gene TP53, wild-type (wt) for 70% of patients, regulates redox homeostasis.
Fatemeh Jamali +5 more
doaj +1 more source
RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment
Precision Medical Sciences, EarlyView.This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run +7 more
wiley +1 more source
Veterinary and Comparative Oncology, EarlyView.ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma +6 more
wiley +1 more source
Effect of Auranofin on Ion Transport by Rat Small Intestine
, 1989 Auranofin, applied either mucosally or serosally, increased the potential difference and short-circuit current generated by stripped sheets of rat mid-intestine in a concentration-dependent manner.
Jacqueline Hardcastle +2 more
core +1 more source
Prdx5 in the Regulation of Tuberous Sclerosis Complex Mutation-Induced Signaling Mechanisms
Cells, 2023 (1) Background: Tuberous sclerosis complex (TSC) mutations directly affect mTORC activity and, as a result, protein synthesis. In several cancer types, TSC mutation is part of the driver mutation panel.
Judit Bovari-Biri +3 more
doaj +1 more source