Results 51 to 60 of about 5,328 (197)
Mitochondrial physiology in cardiac muscle of deer mice native to high altitude
The Journal of Physiology, EarlyView.Abstract figure legend High‐altitude deer mice exhibited evolved changes in mitochondrial energy metabolism and reactive oxygen species (ROS) management that may support cardiac performance under cold hypoxic conditions. High‐altitude mice had increased activity of lactate dehydrogenase (LDH) in the heart, probably enhancing the capacity for lactate ...
Ranim Saleem +3 more
wiley +1 more source
Inhibition of auranofin on enzymatic activities of recombinant SjTGR.
, 2013 (A) Percentages of TrxR, GR and Grx activities inhibited by different doses of auranofin with DTNB, GSSG or HED as substrate. (B) Inhibition constant () values of auranofin on recombinant SjTGR in the TrxR assay.
JiaHuang Li (5652532) +8 more
core +1 more source
activity of auranofin and many additional drugs
, 2020 Treatment options for gonorrhoea are scarce. Drug repurposing of bioactive molecules approved for other conditions might therefore be of value. We developed a method for wide-scale, systematic drug repurposing screen to identify molecules with activity ...
Sunniva Foerster +16 more
core +1 more source
Microbiology SpectrumWhile highly effective at killing Gram-positive bacteria, auranofin lacks significant activity against Gram-negative species for reasons that largely remain unclear.
Laísa Quadros Barsé +10 more
doaj +1 more source
Auranofin Activity Exposes Thioredoxin Reductase as a Viable Drug Target in Mycobacterium abscessus
, 2019 Nontuberculous mycobacteria (NTM) are highly drug-resistant, opportunistic pathogens that can cause pulmonary disease. The outcomes of the currently recommended treatment regimens are poor, especially for Mycobacterium abscessus.
van Ingen, Jakko, +9 more
core +1 more source
Journal of Clinical Periodontology, Volume 53, Issue 7, Page 990-1004, July 2026.ABSTRACT Introduction This explanatory pilot study presents a workflow to identify approved drugs, which could be repurposed for periodontitis therapy using salivary proteomics combined with drug‐target database screening. Methods Proteomic analyses of saliva using LC–MS/MS were conducted in two independent settings: a cohort (sub‐study I, N = 187) and
Taisir Bozo +11 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Fungal infection is a serious global health issue, causing approximately 1.5 million mortalities annually. However, clinically available anti-fungal drugs are limited, especially for multidrug-resistant fungal infections.
Jiaying Lin +7 more
doaj +1 more source
Auranofin to prevent progression of pancreatic ductal adenocarcinoma.
, 2016 236 Background: Auranofin, an FDA anti-rheumatic agent shown to have anticancer properties for lung and ovarian cancer has never been studied for pancreatic cancer.
Bing Bing Dai +6 more
core +1 more source
Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting
MedComm – Future Medicine, Volume 5, Issue 2, June 2026.Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi +2 more
wiley +1 more source