Results 51 to 60 of about 4,141 (163)
ChemBioChem, Volume 27, Issue 13, 14 July 2026.The molecular basis of thioredoxin reductase inhibition by antibacterial gold(I) compounds is disclosed. X‐ray crystallography and high‐resolution ESI‐MS reveal selective gold coordination to catalytically relevant cysteine residues of Bc‐TrxR, leading to stable protein–gold adducts and disruption of enzyme redox activity.
Stefano Zineddu +7 more
wiley +1 more source
Mechanisms of Auranofin in the inhibition of gastric cancer cell proliferation and migration
生物医学转化Objective Aims to systematically evaluate the antitumor activity of the repurposed drug Auranofin against gastric cancer cells and to elucidate its multifaceted mechanisms of action.
Wang Wenxuan, Zhu Weijing, Li Yumin
doaj +1 more source
Atomically Precise Trehalose‐Capped Au25 Nanoclusters: Synthesis and Tunable Antimicrobial Activity
Aggregate, Volume 7, Issue 7, July 2026.A one‐pot strategy enables the synthesis of glyconanocluster Au25Tre18, the first atomically precise nanocluster fully capped with a carbohydrate ligand. ABSTRACT The ability to synthesize well‐defined and atomically precise nanoclusters is important both in advancing fundamental understanding of structure–property relationships of nanomaterials and ...
Mohammad Bodiuzzaman +8 more
wiley +1 more source
The mechanism of action of auranofin analogs in B. cenocepacia revealed by chemogenomic profiling
Microbiology SpectrumDrug repurposing efforts led to the discovery of bactericidal activity in auranofin, a gold-containing drug used to treat rheumatoid arthritis. Auranofin kills Gram-positive bacteria by inhibiting thioredoxin reductase, an enzyme that scavenges reactive ...
Dustin T. Maydaniuk +10 more
doaj +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.ABSTRACT Drug repurposing presents a cost‐effective and time‐efficient strategy to identify new therapeutic applications for existing drugs. Recent advances in artificial intelligence, including machine learning, deep learning, knowledge graphs, and natural language processing, have revolutionized this field by enabling automated discovery of drug ...
Alaba Bukola Ogungbite, Malusi Sibiya
wiley +1 more source
Microbiology SpectrumAuranofin, an FDA-approved drug for rheumatoid arthritis, has emerged as a promising antiparasitic medication in recent years. The gold(I) ion in auranofin is postulated to be responsible for its antiparasitic activity.
C. I. Ma +11 more
doaj +1 more source
Journal of Clinical Periodontology, Volume 53, Issue 7, Page 990-1004, July 2026.ABSTRACT Introduction This explanatory pilot study presents a workflow to identify approved drugs, which could be repurposed for periodontitis therapy using salivary proteomics combined with drug‐target database screening. Methods Proteomic analyses of saliva using LC–MS/MS were conducted in two independent settings: a cohort (sub‐study I, N = 187) and
Taisir Bozo +11 more
wiley +1 more source
Frontiers in Microbiology, 2019 Methicillin-resistant/susceptible Staphylococcus aureus (MRSA/MSSA) and Enterococcus faecalis strains are often found in community- and hospital-acquired infections.
Pengfei She +7 more
doaj +1 more source
Nature Communications, 2023 UBA1 is the primary E1 ubiquitin-activating enzyme responsible for generation of activated ubiquitin required for ubiquitination, a process that regulates stability and function of numerous proteins.
Wenjing Yan +17 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source