Results 71 to 80 of about 5,328 (197)

Thioredoxin reductase activity in auranofin treated Brugia spp.

, 2015
(A) Activity of endogenous Brugia thioredoxin reductase from soluble worm lysates following incubation with 1% DMSO or 0.3 μM, 0.1 μM, or 0.03 μM of auranofin in vitro. Percentages indicate the percent activity of TrxR compared to DMSO controls.
Jiri Gut (145726), Prasit Supakorndej (694020), Chris Marcellino (186241), Moses Samje (191176), Steven Chen (145741), Christina A. Bulman (694015), Brian Suzuki (239548), K. C. Lim (140336), Michelle Arkin (694024), Judy A. Sakanari (694026), Alberto A. Rascón, Jr (694017), Aaron Bell (694018), Chris Wilson (694022), Fidelis Cho-Ngwa (191165), Kean-Hooi Ang (694023), Alan R. Wolfe (694021), Giselle M. Knudsen (217467), Anjan Debnath (352163), James H. McKerrow (113918), Nonglak Supakorndej (694019), Chelsea M. Bidlow (694016), Nancy Tricoche (322694), Chris Franklin (694025), David Williams (229939), Sara Lustigman (123305)   +24 more
core   +1 more source

Peptide‐Coupled Gold Nanoclusters: Syntheses, Properties, and Bioapplications

Rare Metals, Volume 45, Issue 4, April 2026.
ABSTRACT Gold nanoclusters (AuNCs) have garnered significant attention in biomedicine. Particularly, peptide‐coupled AuNCs (Pep‐AuNCs) are emerging as a fascinating class of cluster probes that enable highly tailorable design in their optical, catalytic, targeting, and therapeutic capabilities via peptide engineering.
Jie Liu, Huihui Liu, Yafang Zhang, Shihua Li, Xiaorong Song, Huanghao Yang   +5 more
wiley   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, Volume 13, Issue 17, 23 March 2026.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Auranofin inhibits virulence in Pseudomonas aeruginosa

, 2017
Pseudomonas aeruginosa is widely attributed as the leading cause of hospital-acquired infections. Due to intrinsic antibiotic resistance mechanisms and the ability to form biofilms, P. aeruginosa infections are challenging to treat. P. aeruginosa employs
Joey Kuok Hoong Yam, Ziyan Hong, Shu-Sin Chng, Bau Yi Woo, Michael Givskov, Leon Zhen Wei Tan, May Margarette Santillan Salido, Liang Yang, Sam Fong Yau Li   +8 more
core   +1 more source

Synergistic Microbicidal Effect of Auranofin and Antibiotics Against Planktonic and Biofilm-Encased S. aureus and E. faecalis

Frontiers in Microbiology, 2019
Methicillin-resistant/susceptible Staphylococcus aureus (MRSA/MSSA) and Enterococcus faecalis strains are often found in community- and hospital-acquired infections.
Pengfei She, Linying Zhou, Shijia Li, Yiqing Liu, Lanlan Xu, Lihua Chen, Zhen Luo, Yong Wu   +7 more
doaj   +1 more source

Gold–Thiopurine and Thioguanine Platforms for Chemotherapy and Photodynamic Therapy

ChemistryEurope, Volume 4, Issue 3, March 2026.
Gold(I)–thiopurine complexes bearing chromophores and phosphine or N‐heterocyclic carbene ligands were developed as multimodal chemo‐photodynamic agents. They show good stability, moderate lipophilicity, and tunable photoresponse. 6‐TG enhances dark cytotoxicity, 6‐MP improves phototoxicity, and PPh3/NBD provide the most efficient photoactivation ...
Laura Agulló, Juan Carlos Pérez‐Sánchez, María Gil‐Moles, M. Concepción Gimeno   +3 more
wiley   +1 more source

Broadening the Workflow for Synchrotron‐Based X‐Ray Fluorescence and X‐Ray Absorption Spectroscopy Imaging of Low‐Abundance Cellular Metals

Chemistry–Methods, Volume 6, Issue 3, March 2026.
We present an accessible plunge‐freezing and freeze‐drying workflow for preparing adherent mammalian cells for synchrotron‐based nanofocused X‐ray fluorescence (XRF) microscopy and X‐ray absorption spectroscopy (XAS), enabling sub‐micron mapping of metal distribution and chemical speciation.
Joaquin Tamargo‐Azpilicueta, Rafael L. Giner‐Arroyo, Pablo Rivero‐García, Sofia Diaz‐Moreno, Miguel A. Gomez‐Gonzalez, Abbey Telfer, Michelangelo Campanella, Miguel A. De la Rosa, Irene Díaz‐Moreno   +8 more
wiley   +1 more source

The effect of auranofin on the colonic transport of Na+ and fluid in the rat

, 1986
Auranofin in the mucosal fluid caused a dose-dependent inhibition of fluid and Na+ absorption by everted sacs of rat colon. Serosal auranofin was without effect.
P T Hardcastle, D K Kelleher, J D Fondacaro, J Hardcastle   +3 more
core   +1 more source

The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities

MedComm, Volume 7, Issue 3, March 2026.
Diverse diseases converge on NLRP3. We depict a discovery‐to‐clinic track: high‐throughput/phenotypic screens, structure‐guided design, and modality innovation (allosteric inhibitors, interface blockers, degraders) deliver third‐generation, disease‐tailored NLRP3 control.
Chan Zou, Shilong Jiang, Hui Li, Kai Zhao, Dongshen Cao, Guoping Yang   +5 more
wiley   +1 more source

Auranofin amplifies schisandrin A-induced apoptosis through ROS generation and inhibiting the PI3K/Akt pathway in hepatocellular carcinoma

Asian Pacific Journal of Tropical Biomedicine
Objective: To investigate the synergistic effects of auranofm and schisandrin A (SA) on cell proliferation inhibition and apoptosis induction in human hepatocellular carcinoma Hep3B cells.
Hyun Hwangbo, Seon Yeong Ji, Min Yeong Kim, Su Hyun Hong, Sung Ok Kim, Gi-Young Kim, Yung Hyun Choi   +6 more
doaj   +1 more source