Results 81 to 90 of about 5,328 (197)
Toxins, 2017 The AB-type protein toxin from Pasteurella multocida (PMT) contains a functionally important disulfide bond within its catalytic domain, which must be cleaved in the host cell cytosol to render the catalytic domain of PMT into its active conformation ...
Stefan Carle +4 more
doaj +1 more source
Auranofin inhibits virulence pathways in Pseudomonas aeruginosa
, 2023 Pseudomonas aeruginosa is widely attributed as the leading cause of hospital-acquired infections. Due to intrinsic antibiotic resistance mechanisms and the ability to form biofilms, P. aeruginosa infections are challenging to treat. P. aeruginosa employs
Woo, Bau Yi +10 more
core +1 more source
Effect of auranofin on filarial worms in vitro.
, 2015 Effect of auranofin on filarial worms in vitro.
Jiri Gut (145726) +24 more
core +1 more source
, 2007 Cisplatin is an effective antitumor agent for the treatment of several carcinomas. However, the development of resistance to cisplatin represents a serious clinical problem. The effects of auranofin, a gold(I) compound clinically used as an antirheumatic
GANDIN, VALENTINA +5 more
core +1 more source
Primary screening of FDA-approved library identifies auranofin as a potential drug for OS therapy.
, 2018 A. A diagram of the primary screening to select auranofin. B. Auranofin chemical structure (top) and concentration-response curves of auranofin cytotoxic effects on human (MG-63 and KHOS/NP) and canine (Abrams and D17) OS cells (bottom).
Melinda Broward (3233358) +11 more
core +1 more source
Auranofin Disrupts Selenium Metabolism In Clostridium Difficile By Forming A Stable Au-Se Adduct
, 2009 Clostridium difficile is a nosocomial pathogen whose incidence and importance are on the rise. Previous work in our laboratory characterized the central role of selenoenzyme-dependent Stickland reactions in C. difficile metabolism.
Cowart, Darin +4 more
core +2 more sources
Auranofin Targets Thioredoxin Reductases in Trichomonas vaginalis
, 2017 Trichomonas vaginalis is an anaerobic, parasitic protozoan, responsible for trichomoniasis, the world’s most common, non-viral sexually transmitted infection.
Jauregui, Jose
core
, 2016 Auranofin, an organogold compound classified as an anti-rheumatic agent is under phase 2 clinical trials for re-purposing to treat recurrent epithelial ovarian cancer.
Moyeed, Rana +4 more
core +1 more source
The anti-inflammatory effect of auranofin.
Folia Pharmacologica Japonica, 1985 The anti-inflammatory effects of auranofin were studied and compared with those of indomethacin, gold sodium thiomalate (GST) and D-penicillamine. Auranofin was active as indomethacin in inhibiting carrageenan induced paw edema in rats, but was less potent than indomethacin in inhibiting UV-induced erythema in guinea pigs.
HIROI, Jun +8 more
openaire +2 more sources