Results 21 to 30 of about 5,328 (197)

Auranofin Has Advantages over First-Line Drugs in the Treatment of Severe Streptococcus suis Infections

Antibiotics, 2020
Streptococcal toxic shock-like syndrome (STSLS) likely occurs when an individual is infected with the Streptococcus suis (S. suis) epidemic strain and is characterized by a cytokine storm, multiple organ dysfunction syndrome (MODS) and a high incidence ...
Hao Lu, Wenjia Lu, Yongwei Zhu, Chenchen Wang, Liming Shi, Xiaodan Li, Zhaoyuan Wu, Gaoyan Wang, Wenqi Dong, Chen Tan, Manli Liu   +10 more
doaj   +2 more sources

Gold(I) ion and the phosphine ligand are necessary for the anti-Toxoplasma gondii activity of auranofin [PDF]

Microbiology Spectrum
Auranofin, an FDA-approved drug for rheumatoid arthritis, has emerged as a promising antiparasitic medication in recent years. The gold(I) ion in auranofin is postulated to be responsible for its antiparasitic activity.
C. I. Ma, J. A. Tirtorahardjo, S. S. Schweizer, J. Zhang, Z. Fang, L. Xing, M. Xu, D. A. Herman, M. T. Kleinman, B. S. McCullough, A. M. Barrios, R. M. Andrade   +11 more
doaj   +2 more sources

Auranofin accelerates spermidine-induced apoptosis via reactive oxygen species generation and suppression of PI3K/Akt signaling pathway in hepatocellular carcinoma

Fisheries and Aquatic Sciences, 2023
Auranofin is a US Food and Drug Administration (FDA)-approved anti-arthritis medication that functions as a thioredoxin reductase inhibitor. Spermidine, a polyamine present in marine algae, can exert various physiological functions.
Hyun Hwangbo, Da Hye Kim, Min Yeong Kim, Seon Yeong Ji, EunJin Bang, Su Hyun Hong, Yung Hyun Choi, JaeHun Cheong   +7 more
doaj   +1 more source

Anti-Cancer Effects of Auranofin in Human Lung Cancer Cells by Increasing Intracellular ROS Levels and Depleting GSH Levels

Molecules, 2022
Auranofin, as a thioredoxin reductase (TrxR) inhibitor, has promising anti-cancer activity in several cancer types. However, little is known about the inhibitory effect of auranofin on lung cancer cell growth.
Xia Ying Cui, Sun Hyang Park, Woo Hyun Park   +2 more
doaj   +1 more source

Investigating auranofin for the treatment of infected diabetic pressure ulcers in mice and dermal toxicity in pigs

Scientific Reports, 2021
Bacterial infection of pressure ulcers (PUs) are a notable source of hospitalization for individuals with diabetes. This study evaluated the safety profile and efficacy of auranofin to treat diabetic PUs infected with methicillin-resistant Staphylococcus
Haroon Mohammad, Nader S. Abutaleb, Alexandra M. Dieterly, L. Tiffany Lyle, Mohamed N. Seleem   +4 more
doaj   +1 more source

Gold Nanoclusters as Nano-Antibiotic Auranofin Analogues

, 2021
Auranofin, a gold(I)-complex with tetraacetylated thioglucose and triethylphosphine ligands, is an FDA-approved drug used as an anti-inflammatory aid in the treatment of rheumatoid arthritis.
Mingdi, Yan, William, Ndugire, Olof, Ramstrom, N. G. Hasitha, Raviranga, Jingzhe, Lao   +4 more
core   +1 more source

Synergistic Activity of Colistin Combined With Auranofin Against Colistin-Resistant Gram-Negative Bacteria

Frontiers in Microbiology, 2021
Colistin-resistant (Col-R) bacteria are steadily increasing, and are extremely difficult to treat. New drugs or therapies are urgently needed to treat infections caused by these pathogens.
Xiaoxuan Feng, Xiaoxuan Feng, Shuai Liu, Shuai Liu, Yang Wang, Yang Wang, Yulin Zhang, Yulin Zhang, Yulin Zhang, Lingxiao Sun, Lingxiao Sun, Haibo Li, Haibo Li, Haibo Li, Chunlei Wang, Chunlei Wang, Chunlei Wang, Yingmei Liu, Yingmei Liu, Yingmei Liu, Bin Cao, Bin Cao, Bin Cao, Bin Cao, Bin Cao   +24 more
doaj   +1 more source

Auranofin Attenuates Non-Alcoholic Fatty Liver Disease by Suppressing Lipid Accumulation and NLRP3 Inflammasome-Mediated Hepatic Inflammation In Vivo and In Vitro

Antioxidants, 2020
Non-alcoholic fatty liver disease (NAFLD) causes liver dysfunction and is associated with obesity and type 2 diabetes. Chronic inflammation is associated not only with the development of NAFLD, but also with hepatic diseases, including steatohepatitis ...
Hyun Hwangbo, Min Yeong Kim, Seon Yeong Ji, So Young Kim, Hyesook Lee, Gi-Young Kim, Cheol Park, Young-Sam Keum, Su Hyun Hong, Jaehun Cheong, Yung Hyun Choi   +10 more
doaj   +1 more source

Auranofin, a Gold(I)-Containing Antirheumatic Compound, Activates Keap1/Nrf2 Signaling via Rac1/iNOS Signal and Mitogen-Activated Protein Kinase Activation

Journal of Pharmacological Sciences, 2010
Auranofin (2,3,4,6-tetra-O-acetyl-1-thio-β-d-glucopyranosato-S-[triethylphosphine] gold) is a gold(I)-containing antirheumatic drug that possesses anti-inflammatory properties.
Nam-Hoon Kim, Mi-Kyung Oh, Hyo Jung Park, In-Sook Kim   +3 more
doaj   +1 more source

In vivo efficacy of auranofin in a hamster model of Clostridioides difficile infection

Scientific Reports, 2021
Clostridioides difficile infections (CDIs) are an urgent public health threat worldwide and are a leading cause of morbidity and mortality in healthcare settings. The increasing incidence and severity of infections combined with the scarcity of effective
Nader S. Abutaleb, Mohamed N. Seleem
doaj   +1 more source