Results 11 to 20 of about 5,328 (197)
Antileishmanial activity of auranofin against Leishmania major in vitro
International Archives of Health Sciences, 2022 Aim: Despite the various studies done in the field of cutaneous leishmaniasis treatment, there is still no perfect and safe drug for definite treatment of this disease. Therefore, the quest to find an appropriate drug continues.
Mohammad Ezati Mehmandust Olya +5 more
doaj +2 more sources
Auranofin, a thioredoxin reductase inhibitor, causes platelet death through calcium overload
Platelets, 2019 Platelets are central to normal hemostasis and must be tightly controlled to prevent thrombosis. However, drug treatments that also affect platelets could lead to unwanted side effects on hemostasis or thrombosis.
Matthew T. Harper
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Chlorogenic Acid Supplementation Benefits Zebrafish Embryos Exposed to Auranofin [PDF]
Pharmaceutics, 2020 Antioxidant supplementation may potentially be beneficial for embryonic development to reduce complications associated with increased levels of oxidative stress. Chlorogenic acid, one of the key polyphenolic antioxidants in S.
Jasper Z. S. Chiu +4 more
doaj +3 more sources
Auranofin Releasing Antibacterial and Antibiofilm Polyurethane Intravascular Catheter Coatings [PDF]
Frontiers in Cellular and Infection Microbiology, 2019 Intravascular catheter related bloodstream infections (CRBSIs) are a leading cause of hospital-acquired infections worldwide, resulting not only in the burden of cost and morbidity for patients but also in the over-consumption of medical resources for ...
Hanyang Liu +6 more
doaj +2 more sources
Efficacy of auranofin as an inhibitor of desmoid progression
Scientific Reports, 2022 Anticancer drugs and molecular targeted therapies are used for refractory desmoid-type fibromatosis (DF), but occasionally cause severe side effects. The purpose of this study was to identify an effective drug with fewer side effects against DF by drug ...
Kan Ito +12 more
doaj +2 more sources
In Vitro Investigation of Auranofin as a Treatment for Clostridium difficile Infection [PDF]
Drugs in R&D, 2020 Background Clostridium difficile infection is the leading cause of hospital-acquired gastrointestinal infection and incidence rates continue to rise. Clostridium difficile infection is becoming increasingly complex to treat owing to the rise in treatment
Christine Roder, Eugene Athan
doaj +2 more sources
PLoS Neglected Tropical DiseasesBackgroundAuranofin is an approved anti-rheumatic drug that has a broad-range inhibitory action against several microorganisms, including human pathogenic fungi.
Marcos de Abreu Almeida +12 more
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Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome
Communications Biology, 2021 Using mouse models of liver fibrosis, Kim et al examined the mechanisms underlying the antifibrotic inhibition of the NLRP3 inflammasome by auranofin. They demonstrated that auranofin-induced inhibition of the NLRP3 inflammasome in bone marrow-derived ...
Hyun Young Kim +10 more
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Auranofin as a Novel Anticancer Drug for Anaplastic Thyroid Cancer
PharmaceuticalsBackground/Objectives: Anaplastic thyroid cancer (ATC) is an aggressive and rare cancer with a poor prognosis, and traditional therapies have limited efficacy.
Seung-Chan An +7 more
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Enhanced Eryptosis Following Auranofin Exposure [PDF]
Cellular Physiology and Biochemistry, 2015 Background/Aims: The antiinflammatory, antimicrobial and anticancer drug auranofin has previously been shown to trigger apoptosis, the suicidal death of nucleated cells. Side effects of the drug include anaemia.
Kousi Alzoubi +3 more
doaj +2 more sources