Results 11 to 20 of about 4,141 (163)

Antileishmanial activity of auranofin against Leishmania major in vitro

International Archives of Health Sciences, 2022
Aim: Despite the various studies done in the field of cutaneous leishmaniasis treatment, there is still no perfect and safe drug for definite treatment of this disease. Therefore, the quest to find an appropriate drug continues.
Mohammad Ezati Mehmandust Olya, Mahdi Delavari, Mohsen Arbabi, Sima Rasti, Hossein Hooshyar, Morteza Salimian   +5 more
doaj   +1 more source

Auranofin accelerates spermidine-induced apoptosis via reactive oxygen species generation and suppression of PI3K/Akt signaling pathway in hepatocellular carcinoma

Fisheries and Aquatic Sciences, 2023
Auranofin is a US Food and Drug Administration (FDA)-approved anti-arthritis medication that functions as a thioredoxin reductase inhibitor. Spermidine, a polyamine present in marine algae, can exert various physiological functions.
Hyun Hwangbo, Da Hye Kim, Min Yeong Kim, Seon Yeong Ji, EunJin Bang, Su Hyun Hong, Yung Hyun Choi, JaeHun Cheong   +7 more
doaj   +1 more source

Anti-Cancer Effects of Auranofin in Human Lung Cancer Cells by Increasing Intracellular ROS Levels and Depleting GSH Levels

Molecules, 2022
Auranofin, as a thioredoxin reductase (TrxR) inhibitor, has promising anti-cancer activity in several cancer types. However, little is known about the inhibitory effect of auranofin on lung cancer cell growth.
Xia Ying Cui, Sun Hyang Park, Woo Hyun Park   +2 more
doaj   +1 more source

Structural basis of ligand selectivity in FAD/NAD(P)H-dependent dehydrogenases: insights from trypanothione reductase and type II NADH dehydrogenase. [PDF]

Protein Sci
Abstract FAD/NAD(P)H‐dependent dehydrogenases form a structurally conserved family of redox enzymes that participate in essential metabolic processes across parasites and higher organisms. Among them, trypanothione reductase (TR) is a key component of the redox metabolism of Leishmania species and represents an attractive target for antileishmanial ...
Perrone GCM, Spadone S, Francavilla AL, Morselli S, Todisco S, Ortalli M, Mendoza-Roldan JA, Scaglione V, Sgobba MN, Guerra L, Belluti F, Varani S, Otranto D, De Grassi A, Volpicella M, Pierri CL.   +15 more
europepmc   +2 more sources

Investigating auranofin for the treatment of infected diabetic pressure ulcers in mice and dermal toxicity in pigs

Scientific Reports, 2021
Bacterial infection of pressure ulcers (PUs) are a notable source of hospitalization for individuals with diabetes. This study evaluated the safety profile and efficacy of auranofin to treat diabetic PUs infected with methicillin-resistant Staphylococcus
Haroon Mohammad, Nader S. Abutaleb, Alexandra M. Dieterly, L. Tiffany Lyle, Mohamed N. Seleem   +4 more
doaj   +1 more source

Auranofin Attenuates Non-Alcoholic Fatty Liver Disease by Suppressing Lipid Accumulation and NLRP3 Inflammasome-Mediated Hepatic Inflammation In Vivo and In Vitro

Antioxidants, 2020
Non-alcoholic fatty liver disease (NAFLD) causes liver dysfunction and is associated with obesity and type 2 diabetes. Chronic inflammation is associated not only with the development of NAFLD, but also with hepatic diseases, including steatohepatitis ...
Hyun Hwangbo, Min Yeong Kim, Seon Yeong Ji, So Young Kim, Hyesook Lee, Gi-Young Kim, Cheol Park, Young-Sam Keum, Su Hyun Hong, Jaehun Cheong, Yung Hyun Choi   +10 more
doaj   +1 more source

Synergistic Activity of Colistin Combined With Auranofin Against Colistin-Resistant Gram-Negative Bacteria

Frontiers in Microbiology, 2021
Colistin-resistant (Col-R) bacteria are steadily increasing, and are extremely difficult to treat. New drugs or therapies are urgently needed to treat infections caused by these pathogens.
Xiaoxuan Feng, Xiaoxuan Feng, Shuai Liu, Shuai Liu, Yang Wang, Yang Wang, Yulin Zhang, Yulin Zhang, Yulin Zhang, Lingxiao Sun, Lingxiao Sun, Haibo Li, Haibo Li, Haibo Li, Chunlei Wang, Chunlei Wang, Chunlei Wang, Yingmei Liu, Yingmei Liu, Yingmei Liu, Bin Cao, Bin Cao, Bin Cao, Bin Cao, Bin Cao   +24 more
doaj   +1 more source

Auranofin, a Gold(I)-Containing Antirheumatic Compound, Activates Keap1/Nrf2 Signaling via Rac1/iNOS Signal and Mitogen-Activated Protein Kinase Activation

Journal of Pharmacological Sciences, 2010
Auranofin (2,3,4,6-tetra-O-acetyl-1-thio-β-d-glucopyranosato-S-[triethylphosphine] gold) is a gold(I)-containing antirheumatic drug that possesses anti-inflammatory properties.
Nam-Hoon Kim, Mi-Kyung Oh, Hyo Jung Park, In-Sook Kim   +3 more
doaj   +1 more source

In vivo efficacy of auranofin in a hamster model of Clostridioides difficile infection

Scientific Reports, 2021
Clostridioides difficile infections (CDIs) are an urgent public health threat worldwide and are a leading cause of morbidity and mortality in healthcare settings. The increasing incidence and severity of infections combined with the scarcity of effective
Nader S. Abutaleb, Mohamed N. Seleem
doaj   +1 more source

Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome

Communications Biology, 2021
Using mouse models of liver fibrosis, Kim et al examined the mechanisms underlying the antifibrotic inhibition of the NLRP3 inflammasome by auranofin. They demonstrated that auranofin-induced inhibition of the NLRP3 inflammasome in bone marrow-derived ...
Hyun Young Kim, Young Jae Choi, Sang Kyum Kim, Hyunsung Kim, Dae Won Jun, Kyungrok Yoon, Nayoun Kim, Jungwook Hwang, Young-Mi Kim, Sung Chul Lim, Keon Wook Kang   +10 more
doaj   +1 more source