Results 51 to 60 of about 2,801,158 (293)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Co-targeting of VEGFR2 and PD-L1 promotes survival and vasculature normalization in pleural mesothelioma

OncoImmunology
Pleural mesothelioma (PM) is an aggressive cancer caused by asbestos exposure, with limited treatment options and poor prognosis, highlighting the need for more effective therapies.
Sophie Rovers, Jonas Van Audenaerde, Ruben Verloy, Jorrit De Waele, Louize Brants, Christophe Hermans, Ho Wa Lau, Céline Merlin, Maria Möller Ribas, Peter Ponsaerts, Steven Van Laere, Filip Lardon, An Wouters, Scott A. Fisher, Jan van Meerbeeck, Elly Marcq, Evelien Smits   +16 more
doaj   +1 more source

Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell lung cancer

Redox Biology, 2021
Auranofin (AF) is an FDA-approved antirheumatic drug with anticancer properties that acts as a thioredoxin reductase 1 (TrxR) inhibitor. The exact mechanisms through which AF targets cancer cells remain elusive.
Laurie Freire Boullosa, Jinthe Van Loenhout, Tal Flieswasser, Jorrit De Waele, Christophe Hermans, Hilde Lambrechts, Bart Cuypers, Kris Laukens, Esther Bartholomeus, Vasiliki Siozopoulou, Winnok H. De Vos, Marc Peeters, Evelien L.J. Smits, Christophe Deben   +13 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Protein-level profiling of TIGIT axis components in human PDAC reveals immune–suppressive expression patterns

Cancer Immunology, Immunotherapy
Purpose In pancreatic ductal adenocarcinoma (PDAC), immune checkpoint inhibitors have shown limited efficacy, and the role of the TIGIT axis remains underexplored.
D. Quatannens, Y. Verhoeven, S. van der Heijden, D. Peeters, J. Claes, C. Hermans, H. Lambrechts, K. Zwaenepoel, P. van Dam, M. Peeters, H. Prenen, S. Koljenovic, J. De Waele, C. Faes, F. Lardon, G. Roeyen, E. Smits, J. Van Audenaerde   +17 more
doaj   +1 more source

Heterogeneous-k-core versus Bootstrap Percolation on Complex Networks

, 2010
We introduce the heterogeneous-$k$-core, which generalizes the $k$-core, and contrast it with bootstrap percolation. Vertices have a threshold $k_i$ which may be different at each vertex.
A. E. Holroyd, A. V. Goltsev, B. Bollobas, G. J. Baxter, J. F. F. Mendes, J. I. Alvarez-Hamelin, S. N. Dorogovtsev   +6 more
core   +1 more source

Control core of undirected complex networks

Physica A: Statistical Mechanics and its Applications, 2023
8 pages,5 ...
Zhengzhong Yuan, Jingwen Li, Zhesi Shen, Li Hu, Chen Zhao   +4 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Discussion on the evolution of architecture of the core network of cellular Internet of things

Dianxin kexue, 2023
At present, there are two Internet of things networks facing 2G, 4G, NB-IoT and facing toB core networks.In order to simplify the network, enhance the capability, enhance the benefit, and facilitate the operation and maintenance, it is necessary to ...
Hongyuan MA, Wei ZHOU, Yan FU, Yongping SHAO, Dan LI   +4 more
doaj  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source