Results 71 to 80 of about 728,641 (268)
Clinical & Translational Immunology, 2020 Objectives With the poorest 5‐year survival of all cancers, improving treatment for pancreatic cancer is one of the biggest challenges in cancer research.
Jonas RM Van Audenaerde +15 more
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Future InternetFifth-Generation (5G) cellular networks extensively utilize subscriber identifiers throughout the protocol stack, thereby linking subscribers to their activities on the network.
Paul Scalise +2 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
, 2015 The main objective of SIRGAS (Sistema de Referencia Geocentrico para las Americas) is to provide an accurate spatial and time-referenced infrastructure as a basis for Earth System research and to support scientific and practical applications based on high-precise positioning.
Sánchez, L. +4 more
openaire +2 more sources
npj Precision OncologyPancreatic ductal adenocarcinoma (PDAC) features a dense desmoplastic stroma, limiting drug delivery and promoting chemoresistance. While anti-angiogenic strategies have shown limited success, underexplored pro-angiogenic approaches may improve perfusion
Ruben Verloy +10 more
doaj +1 more source
Toward Self-Sovereign Management of Subscriber Identities in 5G/6G Core Networks
Telecom5G systems have delivered on their promise of seamless connectivity and efficiency improvements since their global rollout began in 2020. However, maintaining subscriber identity privacy on the network remains a critical challenge.
Paul Scalise +2 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Network slicing scheme for heterogeneous power wireless communication networks
Dianxin kexue, 2020 Targeted at power communication networks,the concepts of vertical and horizontal slicing was introduced,the slicing enabler technologies,then explain the technial challenges of realizing network slicing in power communication networks,finally a slicing ...
Yan ZHEN, Mengyue YU, Haibo ZHAO
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source