Results 81 to 90 of about 2,801,158 (293)

Performance evaluation of multi-core multi-cluster architecture

, 2014
A multi-core cluster is a cluster composed of numbers of nodes where each node has a number of processors, each with more than one core within each single chip. Cluster nodes are connected via an interconnection network.
Hamid, Norhazlina, Walters, Robert John, Wills, Gary Brian   +2 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Novel combination immunotherapy for pancreatic cancer: potent anti‐tumor effects with CD40 agonist and interleukin‐15 treatment

Clinical & Translational Immunology, 2020
Objectives With the poorest 5‐year survival of all cancers, improving treatment for pancreatic cancer is one of the biggest challenges in cancer research.
Jonas RM Van Audenaerde, Elly Marcq, Bianca vonScheidt, Ashleigh S Davey, Amanda J Oliver, Jorrit De Waele, Delphine Quatannens, Jinthe Van Loenhout, Patrick Pauwels, Geert Roeyen, Filip Lardon, Clare Y Slaney, Marc Peeters, Michael H Kershaw, Phillip K Darcy, Evelien LJM Smits   +15 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

A Survey of 5G Core Network User Identity Protections, Concerns, and Proposed Enhancements for Future 6G Technologies

Future Internet
Fifth-Generation (5G) cellular networks extensively utilize subscriber identifiers throughout the protocol stack, thereby linking subscribers to their activities on the network.
Paul Scalise, Michael Hempel, Hamid Sharif   +2 more
doaj   +1 more source

DISCUS: the distributed core for ubiquitous broadband access [PDF]

, 2013
A new end to end architecture based on Long-Reach Passive Optical Network (LR-PON) with wireless integration, a distributed core built of optical transparency islands and an OpenFlow-based control plane, which is being developed in the EU project DISCUS,
Achouche, Mohand, Doran, Nick, Montalvo, Julio, O'Sullivan, Barry, Ossieur, Peter, Parsons, Nick, Payne, David, Pfeiffer, Thomas, Rohde, Harald, Ruffini, Marco, Schiano, Marco, Wessäly, Roland, Wosinska, Lena, Yin, Xin   +13 more
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Short cold atmospheric plasma treatment preserves vascular quiescence in 3D tumor-stroma-endothelial models of pancreatic cancer in vitro and in ovo

npj Precision Oncology
Pancreatic ductal adenocarcinoma (PDAC) features a dense desmoplastic stroma, limiting drug delivery and promoting chemoresistance. While anti-angiogenic strategies have shown limited success, underexplored pro-angiogenic approaches may improve perfusion
Ruben Verloy, Emma Peeters, Angela Privat-Maldonado, Sophie Rovers, Ho Wa Lau, Louize Brants, Christophe Hermans, Jorrit De Waele, Christophe Deben, Evelien Smits, Annemie Bogaerts   +10 more
doaj   +1 more source

Toward Self-Sovereign Management of Subscriber Identities in 5G/6G Core Networks

Telecom
5G systems have delivered on their promise of seamless connectivity and efficiency improvements since their global rollout began in 2020. However, maintaining subscriber identity privacy on the network remains a critical challenge.
Paul Scalise, Michael Hempel, Hamid Sharif   +2 more
doaj   +1 more source