Results 91 to 100 of about 683,800 (267)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Evolution of core network oriented to 5G
Dianxin kexue, 2019 The 5G network is dedicated to the vision of “internet of everythingand information is easy to reach”.5G network adopts scene design to meet diverse business needs in a more flexible way.Based on the core network target architecture oriented to 5G,the ...
Hongyuan MA +3 more
doaj
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Research on the Virtualized Core Network
Dianxin kexue, 2014 Scenarios of virtualized core network were analyzed firstly, then virtualized core network architecture and related key technologies were discussed. Finally, the core network virtualization processes and procedures were forecasted.
Xiaojuan Hu, Huiling Zhao
doaj
SDN-Based Network Slicing Mechanism for a Scalable 4G/5G Core Network: A Kubernetes Approach. [PDF]
Sensors (Basel), 2021 Botez R +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior. [PDF]
Genes Dev, 2021 Naxerova K +12 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Single worm transcriptomics identifies a developmental core network of oscillating genes with deep conservation across nematodes. [PDF]
Genome Res, 2021 Sun S, Rödelsperger C, Sommer RJ.
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source