Results 41 to 50 of about 192,260 (267)
Revista de Derecho (Coquimbo)El objetivo de la presente contribución consiste en alcanzar un análisis crítico de la regulación normativa del femicidio en Chile. Después de develar la confusión presente a partir de la definición del fenómeno, en la parte central del trabajo se ...
EMANUELE CORN
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Bioresources and Bioprocessing, 2021 Highlights IL-based sugaring-out extraction was applied to separate LA from fermentation broth Different ILs and saccharides consisting systems were examined The ability to form ATPS is in the order of [Hmim]BF4 ≈ [Bmim]BF4˃[Emim]BF4 The partition ...
Xu Zhou +8 more
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Revista de Derecho (Coquimbo), 2015 El objetivo de la presente contribución consiste en alcanzar un análisis crítico de la regulación normativa del femicidio en Chile. Después de develar la confusión presente a partir de la definición del fenómeno, en la parte central del trabajo se ...
Emanuele Corn
doaj
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Biotechnology for Biofuels, 2021 Background Lignocellulosic feedstocks have attracted much attention as a potential carbon source for lactic acid (LA) production because of their ready availability, sustainability, and renewability.
Yaqin Sun +6 more
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