Results 41 to 50 of about 417,000 (313)
Revista de Derecho (Coquimbo)El objetivo de la presente contribución consiste en alcanzar un análisis crítico de la regulación normativa del femicidio en Chile. Después de develar la confusión presente a partir de la definición del fenómeno, en la parte central del trabajo se ...
EMANUELE CORN
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Animal Biodiversity and Conservation, 2007 Cambio climático y anfibios Las historias vitales de los anfibios son sumamente sensibles a la temperatura y a la precipitación, y hay una clara evidencia que el reciente cambio climático ha tenido como resultado para algunas especies una anticipación ...
P. S. Corn
doaj +3 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Revista de Derecho (Coquimbo), 2015 El objetivo de la presente contribución consiste en alcanzar un análisis crítico de la regulación normativa del femicidio en Chile. Después de develar la confusión presente a partir de la definición del fenómeno, en la parte central del trabajo se ...
Emanuele Corn
doaj
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Bioresources and Bioprocessing, 2021 Highlights IL-based sugaring-out extraction was applied to separate LA from fermentation broth Different ILs and saccharides consisting systems were examined The ability to form ATPS is in the order of [Hmim]BF4 ≈ [Bmim]BF4˃[Emim]BF4 The partition ...
Xu Zhou +8 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source