Results 31 to 40 of about 304,882 (317)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Ascorbic acid is involved in melatonin-induced salinity tolerance of maize (Zea mays L.) by regulating antioxidant and photosynthetic capacities

Photosynthetica
Melatonin (MT), an indole compound, can boost plant growth under abiotic stress conditions. This experiment aims to elucidate the synergistic effect of MT and ascorbic acid (AsA) in mitigating salinity stress by assessing the photosynthetic and ...
M. ZHU, T. GUO, Y.B. LIU, R. XIAO, T. YU, J.X. HUANG, W.L. DU, X.M. ZHONG, B. SONG, F.H. LI   +9 more
doaj   +1 more source

Climate change and amphibians

Animal Biodiversity and Conservation, 2007
Cambio climático y anfibios Las historias vitales de los anfibios son sumamente sensibles a la temperatura y a la precipitación, y hay una clara evidencia que el reciente cambio climático ha tenido como resultado para algunas especies una anticipación ...
P. S. Corn
doaj   +3 more sources

Mapping Quantitative Trait Loci Associated With Resistance to Aflatoxin Accumulation in Maize Inbred Mp719

Frontiers in Microbiology, 2020
Aflatoxins are carcinogenic and toxic compounds produced principally by fungal species Aspergillus flavus (Link: Fries) and A. parasiticus (Speare), which are common contaminants of food and feed.
Erika D. Womack, W. Paul Williams, Gary L. Windham, Wenwei Xu, Wenwei Xu   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Exogenous melatonin alleviates nicosulfuron toxicity by regulating the growth, photosynthetic capacity, and antioxidative defense of sweet corn seedlings

Photosynthetica
Improper use of nicosulfuron (NSF) may induce harmful effects on plants during weed control. Melatonin (MT) regulates photosynthetic and physiological processes in plants.
J.X. HUANG, Y.B. LIU, R. XIAO, T. YU, T. GUO, H.W. WANG, X.L. LV, X.N. LI, M. ZHU, F.H. LI   +9 more
doaj   +1 more source

Influence of Abiotic Stresses on Morphophysiological Characteristics and Biological Value of Grain Sorghum bicolor (L.) Moench

International Journal of Plant Biology, 2023
Sorghum is the agricultural crop most adaptable to the effects of abiotic factors, able to tolerate prolonged soil and air droughts, changes in air temperature, insufficient precipitation, salinization, acidification of soils, and many others with the ...
Oksana Pavlovna Kibalnik, Irina Alexandrovna Sazonova, Yulia Valerievna Bochkareva, Vera Valerievna Bychkova, Dmitry Sergeevich Semin   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Ultrasound Treatment Combined with Rhamnolipids for Eliminating the Biofilm of Bacillus cereus

Microorganisms
Biofilm formation by Bacillus cereus is a major cause of secondary food contamination, leading to significant economic losses. While rhamnolipids (RLs) have shown effectiveness against Bacillus cereus, their ability to remove biofilms is limited when ...
Ben Niu, Yiming Sun, Yongwu Niu, Shan Qiao   +3 more
doaj   +1 more source