Results 51 to 60 of about 4,736,377 (208)

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Accelerated corneal collagen cross-linking should be modified

, 2014
George D Kymionis,1,2 Konstantinos I Tsoulnaras11Vardinoyiannion Eye Institute of Crete, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece; 2Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL,
Kymionis GD, Kymionis, G.D., Tsoulnaras, K.I., Tsoulnaras KI   +3 more
core   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Structural corneal changes identified with the use of confocal microscopy after accelerated CXL for keratoconus

Journal of Ophthalmology, 2020
Background: Post-crosslinking (CXL) biomicroscopic changes in patients with keratoconus can be detected by confocal microscopy. Few studies reported on morphological changes in the cornea after CXL.
L.F. Troichenko, K.V. Sereda, G.I. Drozhzhyna, O.M. Ivanova, N.V. Medvedovska   +4 more
doaj   +1 more source

Ocular morphology and morphometry of the great egret (Ardea alba): A comprehensive anatomical description

The Anatomical Record, EarlyView.
Abstract Ardea alba (Linnaeus, 1758) is widely distributed, yet knowledge of its ocular morphology remains limited. This study described the morphometry and morphology of the eyeball and its accessory glands in six specimens using radiography, morphometry, light and scanning electron microscopy, and 3D scanning.
Julia Vaz Feio, Max Alex Santos Ferreira, Iara Fernanda Lima do Espírito Santo, Elane Guerreiro Giese, Érika Branco, Antônio Basílio Guerreiro Junior, Ana Rita de Lima   +6 more
wiley   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Transepithelial iontophoresis corneal collagen cross-linking for progressive keratoconus: initial clinical outcomes

, 2014
To report initial clinical results of transepithelial corneal collagen cross-linking with iontophoresis (I-CXL)
Legrottaglie, Emanuela F, Emanuela F. Legrottaglie, Pietro Rosetta, Vinciguerra, Riccardo, Riccardo Vinciguerra, Fabrizio I. Camesasca, Raffaele Piscopo, Romano, Vito, Vinciguerra, Paolo, Randleman, J. Bradley, Piscopo, Raffaele, J. Bradley Randleman, AZZOLINI, CLAUDIO, Camesasca, Fabrizio I, Paolo Vinciguerra, Vito Romano, Rosetta, Pietro, Claudio Azzolini, Piscopo R., Legrottaglie E. F., Vinciguerra R., Romano V., Vinciguerra P., Rosetta P., Camesasca F. I., Randleman J. B., Azzolini C.   +26 more
core   +1 more source

Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology

Health Care Science, EarlyView.
Bringing attention to the moral dilemmas raised by xenotransplantation and the continuous creation of standardized frameworks for donor technology and biosafety risk management, with a focus on striking a balance between patient safety, medical innovation, and ethical obligation.
Sankhajyoti Saha, Moubani Dutta, Agnihiya Bosu   +2 more
wiley   +1 more source

Intraoperative Corneal Thickness Measurements During Corneal Collagen Cross-Linking With Hypoosmolar Riboflavin Solution in Thin Corneas

, 2012
Purpose: To monitor corneal thickness during the corneal collagen cross-linking procedure in corneal ectatic diseases, by using isoosmolar riboflavin solution with 20% dextran and hypoosmolar riboflavin solution without ...
Kaya, Vedat, Yilmaz, Omer Faruk, YILDIRIM, CANAN ASLI   +2 more
core   +1 more source