Results 91 to 100 of about 9,660 (240)

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source

Airway Involvement in Conradi–Hünermann–Happle Syndrome: A Novel Clinical Manifestation

The Laryngoscope, EarlyView.
We report the first documented case of airway involvement in Conradi–Hünermann–Happle syndrome (CDPX2), an X‐linked dominant form of chondrodysplasia punctata caused by pathogenic variants in EBP. A 2‐month‐old female with genetically confirmed CDPX2 developed severe subglottic stenosis and persistent respiratory distress requiring CPAP; cross ...
Enrique G. Villarreal, Jackie Chiang, Evan J. Propst, Nikolaus E. Wolter   +3 more
wiley   +1 more source

Pathological classification of Fuchs endothelial corneal dystrophy into several types and their relationships with CTG18.1 expansion repeats

The Journal of Pathology, EarlyView.
Abstract Late‐onset Fuchs endothelial corneal dystrophy (FECD) is the most common primary disease of the corneal endothelium and the leading indication for corneal transplantation in Western countries. It is characterized by progressive accumulation, over two to three decades, of extracellular matrix (ECM) components in Descemet's membrane (DM ...
Hanielle Vaitinadapoulé, Daria Onitiu, Corantin Maurin, Gauthier Travers, Emmanuel Crouzet, Oliver Dorado‐Cortez, Sylvain Poinard, Zhiguo He, Fabien Forest, Edouard Ollier, Renaud Touraine, Philippe Gain, Jean‐Marc Perone, Gilles Thuret, the French Fuchs Study Group (FFSG), Diane Bernheim, Christophe Chiquet, Vincent Borderie, Tristan Bourcier, Jean‐Louis Bourges, Frédéric Chiambaretta, Béatrice Cochener, Louis Arnould, Florian Baudin, Catherine Creuzot, Vincent Daien, Alexandre Denoyer, Bernard Duchesne, Nicolas Duquesne, Pierre Fournie, Anne‐Sophie Gauthier, Philippe Gain, Gilles Thuret, Louis Hoffart, François Majo, Marc Muraine, Romain Mouchel, Jean Marc Perone, Jean Claude Quintyn, Alexandra Rabot, Alain Saad, Damien Gatinel, Pierre‐Yves Santiago, Jean‐Michel Bosc, David Touboul, Bertrand Vabres   +45 more
wiley   +1 more source

Unlocking the potential of stimuli‐responsive liquid crystal polymer bio‐interfaces for adaptive cell modulation

Responsive Materials, EarlyView.
This Perspective discusses the potential of stimuli‐responsive liquid crystal polymer bio‐interfaces in modulating cell behavior as next generation dynamic artificial scaffolds. Unlike current artificial biomaterials that have static properties, LCPs offer fast, reversible, and spatially programmable deformation that reflects the dynamic properties of ...
Ruth M. C. Verbroekken, Burcu Gumuscu, Albert P. H. J. Schenning   +2 more
wiley   +1 more source

Congenital aniridia: European COST action ANIRIDIA‐NET guidelines for diagnosis, management and care

Acta Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare ocular disorder affecting the majority of eye structures and can be associated with systemic manifestations. The main visible phenotypic characteristic is the partial or complete absence of the iris; however, foveal hypoplasia is a more frequent and reliable clinical sign. Other ocular comorbidities are associated
Davide Romano, Vito Romano, Alejandra Daruich, Giulio Ferrari, Matthieu Robert, Francesco Semeraro, Neil Lagali, Dominique Bremond‐Gignac, the ANIRIDIA‐NET Clinical Guidelines Working Group, Miriam Barbany, Claus Cursiefen, Stefano Ferrari, Francisco Figueiredo, Christina Grupcheva, Jesper Hjortdal, Elke Kreps, Erlend Landsend, Laura Mauring, Hilde Pedersen, Nora Szentmáry, Bogumil Wowra, the Aniridia‐Europa and Geniris Working Group, Sophie Valleix, Juan Álvarez de Toledo, James Lauderdale, Tor Paaske Utheim, Paolo Rama   +26 more
wiley   +1 more source

Clinical recommendations for early identification of patients with open‐angle glaucoma at higher risk of low adherence to topical treatment: An Italian Delphi consensus

Acta Ophthalmologica, EarlyView.
Abstract Purpose It is important for clinicians to identify patients with glaucoma at higher risk of poor adherence to topical therapy at an early stage to prescribe alternative treatments. An expert‐based set of statements was developed to assist clinicians in the early identification of patients at high risk of low adherence and subsequent poorer ...
Roberto G. Carassa, Giovanni Pomponio, Luca Agnifili, Antonio Maria Fea, Michele Iester, Giorgio Marchini, Enrico Martini, Stefano Miglior, Francesco Oddone, Luca Rossetti, Matteo Sacchi, Carlo Enrico Traverso, Michele Figus   +12 more
wiley   +1 more source

Corrigendum to “Preclinical evaluation of the safety and effectiveness of a new bioartificial cornea” [Bioact. Mater. 2023 (8) 29 265–278]

Bioactive Materials
Cross-linking agents are frequently used to restore corneal properties after decellularization, and it is especially important to select an appropriate method to avoid excessive cross-linking.
Yansha Hao, Jingting Zhou, Ju Tan, Feng Xiang, Zhongliang Qin, Jun Yao, Gang Li, Mingcan Yang, Lingqin Zeng, Wen Zeng, Chuhong Zhu   +10 more
doaj   +1 more source

Occupational exposure to metal welding and cataract: A systematic review and meta‐analysis

Acta Ophthalmologica, EarlyView.
Abstract Background Metal welding generates ultraviolet radiation (UVR) of cataractogenic wavelengths, and UVR emitted during welding has been associated with cataract formation, but results from prior studies are conflicting. Methods We conducted a systematic review and meta‐analysis of epidemiological studies addressing associations between ...
Jakob Bjerager, Esben Meulengracht Flachs, Martin Nissen Hermann, Jens Peter Ellekilde Bonde, Ingrid Sivesind Mehlum, Stinna Skaaby   +5 more
wiley   +1 more source

ELECTRON MICROSCOPY OF THE CORNEAL STROMA AFTER THE STANDARD CROSS-LINKING AND USING FEMTOSECOND LASER IN EXPERIMENT

Офтальмохирургия, 2015
Purpose. The study and comparison of the corneal tissues condition after the standard corneal collagen cross-linking (CXL) and femto-cross-linking in experiment.Material and methods.
V. V. Zotov, N. P. Pashtayev, E. V. Larionov, N. A. Pozdeyeva, S. I. Anisimov   +4 more
doaj