Results 81 to 90 of about 135,941 (356)

Detection of keratoconus Diseases using deep Learning [PDF]

arXiv, 2023
One of the most serious corneal disorders, keratoconus is difficult to diagnose in its early stages and can result in blindness. This illness, which often appears in the second decade of life, affects people of all sexes and races. Convolutional neural networks (CNNs), one of the deep learning approaches, have recently come to light as particularly ...
arxiv  

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Retinal regions shape human and murine Müller cell proteome profile and functionality

Glia, Volume 71, Issue 2, Page 391-414, February 2023., 2023
Main Points We defined Müller cells heterogeneity in the macular and peripheral human retina. Signaling pathways shaping this glial heterogeneity include proteins important for interaction with vesicular secretion, extracellular matrix and cell adhesion.
Lew Kaplan, Corinne Drexler, Anna M. Pfaller, Santra Brenna, Kirsten A. Wunderlich, Andrea Dimitracopoulos, Juliane Merl‐Pham, Maria‐Theresa Perez, Ursula Schlötzer‐Schrehardt, Volker Enzmann, Marijana Samardzija, Berta Puig, Peter Fuchs, Kristian Franze, Stefanie M. Hauck, Antje Grosche   +15 more
wiley   +1 more source

A study exploring the causal relationship between glaucoma and anxiety disorders

Frontiers in Medicine
BackgroundGlaucoma, a leading cause of global blindness, is characterized by optic nerve damage and visual field loss. Previous studies have suggested a potential association between glaucoma and anxiety disorders.
Bin Lin, Bin Lin, Bin Lin, Bin Lin, Bin Lin, Bin Lin, Meng Xu, Meng Xu, Meng Xu, Meng Xu, Meng Xu, Meng Xu, Long-long Chen, Long-long Chen, Long-long Chen, Long-long Chen, Long-long Chen, Long-long Chen, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li   +23 more
doaj   +1 more source

An adaptive algorithm for the cornea modeling from keratometric data [PDF]

, 2010
In this paper we describe an adaptive and multi-scale algorithm for the parsimonious fit of the corneal surface data that allows to adapt the number of functions used in the reconstruction to the conditions of each cornea. The method implements also a dynamical selection of the parameters and the management of noise.
arxiv   +1 more source

Elongated Physiological Structure Segmentation via Spatial and Scale Uncertainty-aware Network [PDF]

arXiv, 2023
Robust and accurate segmentation for elongated physiological structures is challenging, especially in the ambiguous region, such as the corneal endothelium microscope image with uneven illumination or the fundus image with disease interference. In this paper, we present a spatial and scale uncertainty-aware network (SSU-Net) that fully uses both ...
arxiv  

Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study [PDF]

, 2019
Background: Dry eye disease (DED) affects more than 14% of the elderly population causing decrease of quality of life, high costs and vision impairment.
Allegretti, M., Ferrari, M., Garhoefer, G., Lambiase, A., Mantelli, F., Sacchetti, M., Schmetterer, L., Schmidl, D.   +7 more
core   +1 more source

Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers

Advanced Healthcare Materials, EarlyView.
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto, Moisés L. Pinto, Christian Serre   +2 more
wiley   +1 more source

Enhancing Form Stability: Shrink‐Resistant Hydrogels Made of Interpenetrating Networks of Recombinant Spider Silk and Collagen‐I

Advanced Healthcare Materials, EarlyView.
A shrinkage‐resistant hydrogel is developed to confer post‐fabrication shape fidelity. The hydrogel, based on recombinant spider silk protein eADF4(C16)‐RGD and collagen‐I, exhibits tunable mechanical properties and shrink‐resistance in the presence of fibroblasts as well as muscle cells.
Xuen J. Ng, Tilman U. Esser, Vanessa T. Trossmann, Christoph Rudisch, Maren Fiedler, Kaveh Roshanbinfar, Zan Lamberger, Philipp Stahlhut, Gregor Lang, Thomas Scheibel, Felix B. Engel   +10 more
wiley   +1 more source

Long‐term follow‐up and health‐related quality of life among cancer survivors with stage IEA orbital‐type lymphoma after external photon‐beam radiotherapy: Results from a longitudinal study

Hematological Oncology, Volume 40, Issue 5, Page 922-929, December 2022., 2022
Abstract We assessed the long‐term outcomes and treatment‐related adverse effects of patients with Stage I, “orbital‐type” lymphomas that were uniformly treated with photons. All consecutive patients diagnosed with low‐grade, Ann Arbor Stage IEA orbital lymphoma treated between 1999 and 2020 at our department were retrospectively reviewed.
Christian Hoffmann, Philipp Rating, Nikolaos Bechrakis, Anja Eckstein, Ekaterina Sokolenko, Leyla Jabbarli, Henrike Westekemper, Christopher Mohr, Claus Schmeling, Andreas Huettmann, Julia von Tresckow, Sophia Göricke, Cornelius Deuschl, Patricia Johansson, Christoph Poettgen, Thomas Gauler, Nika Guberina, Sourour Moliavi, Martin Stuschke, Maja Guberina   +19 more
wiley   +1 more source