Results 81 to 90 of about 9,329,954 (313)

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

Whole genome sequencing for mutation discovery in a single case of lysosomal storage disease (MPS type 1) in the dog. [PDF]

, 2020
Mucopolysaccharidosis (MPS) is a metabolic storage disorder caused by the deficiency of any lysosomal enzyme required for the breakdown of glycosaminoglycans.
Aguilar, Miriam, Ancona, Devin, Bannasch, Danika, Brown, C. Titus, Cowan, Tina, Knipe, Marguerite, Mansour, Tamer, Moore, Bret, Seada, Haitham, Sebbag, Lionel, Sebbag, Lionel, Thomasy, Sara, Vernau, Karen, Woolard, Kevin   +13 more
core   +3 more sources

Flexible Sensor‐Based Human–Machine Interfaces with AI Integration for Medical Robotics

Advanced Robotics Research, EarlyView.
This review explores how flexible sensing technology and artificial intelligence (AI) significantly enhance human–machine interfaces in medical robotics. It highlights key sensing mechanisms, AI‐driven advancements, and applications in prosthetics, exoskeletons, and surgical robotics.
Yuxiao Wang, Zhipeng Jiang, Sun Hwa Kwon, Matthew Ibrahim, Alexander Dang, Lin Dong   +5 more
wiley   +1 more source

Evolution of Ocular Organ‐On‐Chip Systems for Disease Modelling and Drug Testing: Where are We Now?

Advanced Therapeutics, EarlyView.
The rise in ophthalmic diseases due to aging, screen use, and environmental factors has driven demand for better ocular models. Traditional systems fall short, encouraging the development of organ‐on‐chip devices. These microfluidic platforms replicate eye tissue architecture, enable drug screening, and simulate ocular diseases.
Sara Trujillo
wiley   +1 more source

Effects of Mitomycin C in Early Conjunctival Inflammation after Pterygium Surgery [PDF]

, 2016
Purpose: The purpose of this study was to compare inflammatory events and graft characteristics 1 month and 6 months after conjunctival limbal autograft (CLAU) with and without intraoperative mitomycin C (MMC).
Asaad Ammaar, Mouafk, Campos, Pamela, da Costa Paula, Claudia, Julio Morán, Gemma, Pujol Vives, Pere   +4 more
core   +2 more sources

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Nature Communications, 2018
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions.
Adriana I. Iglesias, A. Mishra, V. Vitart, Y. Bykhovskaya, René Höhn, H. Springelkamp, G. Cuéllar-Partida, P. Gharahkhani, J. C. Bailey, C. Willoughby, Xiaohui Li, S. Yazar, A. Nag, A. Khawaja, O. Polašek, D. Siscovick, P. Mitchell, Y. Tham, J. Haines, L. Kearns, C. Hayward, Yuan Shi, E. V. van Leeuwen, K. Taylor, Jie Jin Elena John Rodney Elizabeth G. Tien Yin Paul N Wang Rochtchina Attia Scott Holliday Wong Baird Xi, J. Wang, E. Rochtchina, J. Attia, Rodney J. Scott, E. Holliday, T. Wong, P. Baird, Jing Xie, M. Inouye, A. Viswanathan, X. Sim, Pieter W. M. Bonnemaijer, J. Rotter, Nicholas G. Martin, T. Zeller, R. Mills, Emmanuelle Souzeau, Sandra E. Staffieri, J. Jonas, I. Schmidtmann, Thibaud S. Boutin, J. Kang, S. Lucas, T. Wong, M. Beutel, James F. Wilson, R. Rand Murray H. Donald L. William G. John David S. Allingham Brilliant Budenz Christen Fingert Friedm, R. Allingham, M. Brilliant, D. Budenz, W. Christen, J. Fingert, D. Friedman, D. Gaasterland, T. Gaasterland, M. Hauser, Peter Kraft, Richard K. Lee, P. Lichter, Yutao Liu, S. Loomis, S. Moroi, M. Pericak-Vance, A. Realini, J. Richards, J. Schuman, W. Scott, Kuldev Singh, A. Sit, D. Vollrath, R. Weinreb, G. Wollstein, D. Zack, Kang Zhang, Peter Ines Jenefer M. Elvira Matthew A. Juan P. Aiden Pa Donnelly Barroso Blackwell Bramon Brown Casas Corv, P. Donnelly, I. Barroso, J. Blackwell, E. Bramon, Matthew A. Brown, J. P. Casas, A. Corvin, P. Deloukas, A. Duncanson, Janusz Jankowski, Hugh S. Markus, C. Mathew, C. Palmer, R. Plomin, A. Rautanen, S. Sawcer, R. Trembath, N. Wood, C. Spencer, G. Band, C. Bellenguez, C. Freeman, G. Hellenthal, E. Giannoulatou, M. Pirinen, R. Pearson, A. Strange, Z. Su, Damjan Vukcevic, C. Langford, S. Hunt, S. Edkins, R. Gwilliam, H. Blackburn, S. Bumpstead, S. Dronov, M. Gillman, Emma V. Gray, Naomi Hammond, Alagurevathi Jayakumar, O. T. McCann, J. Liddle, Simon C. Potter, Radhi Ravindrarajah, M. Ricketts, M. Waller, P. Weston, S. Widaa, P. Whittaker, A. Uitterlinden, E. Vithana, P. Foster, P. Hysi, A. Hewitt, C. Khor, L. Pasquale, G. Montgomery, C. Klaver, T. Aung, N. Pfeiffer, D. Mackey, C. Hammond, Ching-Yu Cheng, J. Craig, Y. Rabinowitz, J. Wiggs, K. Burdon, C. V. van Duijn, S. Macgregor   +148 more
semanticscholar   +1 more source

Single‐Cell Transcriptome Analysis Reveals That Hmga2 Regulates Neuroinflammation and Retinal Function by Modulating Müller Cell Autophagy Through PI3K/AKT Signaling Following MCAO‐Induced Retinal Ischemia

Advanced Science, EarlyView.
Employing snRNA‐seq post‐MCAO‐induced retinal ischemia (RI), this study revealed a novel Hmga2‐high Müller cell subpopulation. Hmga2 knockout alleviated neuroinflammation and RI symptoms, potentially by binding PI3K and regulating Müller cell autophagy.
Weihao Lv, Juzheng Yuan, Zhe Ruan, Ya‐nan Dou, Hongchen Zhang, Xiaowei Fei, Leiying Chen, Zehan Zhang, Kai Yang, Xiuquan Wu, Zhou Fei, Fei Fei   +11 more
wiley   +1 more source

Therapeutic Effect of Human Adipose Tissue-Derived Mesenchymal Stem Cells in Experimental Corneal Failure Due to Limbal Stem Cell Niche Damage [PDF]

, 2017
Producción CientíficaLimbal stem cells are responsible for the continuous renewal of the corneal epithelium. The destruction or dysfunction of these stem cells or their niche induces limbal stem cell deficiency (LSCD) leading to visual loss, chronic pain,
Calonge Cano, Margarita, Galindo de la Rosa, Sara, Herreras Cantalapiedra, José María, López Paniagua, Marina, Mata Sampedro, Ana de la, Nieto Miguel, Teresa, Plata Cordero, María, Rey, Esther   +7 more
core   +2 more sources

Corneal reflex in hemisphere disease [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1972
The contralateral corneal reflex may be absent in patients with a deep lesion of the parietal lobe. Frontal and temporal lobe lesions apparently do not interfere with this reflex.
openaire   +3 more sources

Drug Delivery Technologies for the Treatment of Age‐Related Macular Degeneration

Advanced Science, EarlyView.
There are multiple therapeutic agents available for the treatment of both dry age‐related macular degeneration (AMD) and wet AMD. It is essential to continue innovation by introducing new drug delivery technologies that can incorporate those along with patient compliance and the accessibility of the technology into the early stages of research and ...
J Jesus Rodriguez‐Cruz, Jessica Cutrufello, Michael Lam, Shreya Nallaparaju, Nicholas A. Peppas   +4 more
wiley   +1 more source