Results 31 to 40 of about 25,735 (191)

Activation of TGF-β signaling induces cell death via the unfolded protein response in Fuchs endothelial corneal dystrophy

Scientific Reports, 2017
Fuchs endothelial corneal dystrophy (FECD) is a slowly progressive bilateral disease of corneal endothelium in which accumulation of extracellular matrix (ECM) and loss of corneal endothelial cells (CECs) are phenotypic features.
Naoki Okumura, Keisuke Hashimoto, Miu Kitahara, Hirokazu Okuda, Emi Ueda, Kyoko Watanabe, Makiko Nakahara, Takahiko Sato, Shigeru Kinoshita, Theofilos Tourtas, Ursula Schlötzer-Schrehardt, Friedrich Kruse, Noriko Koizumi   +12 more
doaj   +1 more source

Comparison of Corneal Endothelial Cell Loss between Torsional and Linear Phacoemulsification

Delhi Journal of Ophthalmology, 2014
Purpose: To compare corneal endothelial cell loss between Torsional phacoemulsification and Linear phacoemulsification systems for cataract surgery. Materials and Methods: A prospective randomized study of 100 eyes of 100 patients, who underwent cataract
Amrita Sawhney, Uma Sridhar, Charu Tandon   +2 more
doaj   +1 more source

ROCK inhibitor enhances adhesion and wound healing of human corneal endothelial cells. [PDF]

PLoS ONE, 2013
Maintenance of corneal transparency is crucial for vision and depends mainly on the endothelium, a non-proliferative monolayer of cells covering the inner part of the cornea. When endothelial cell density falls below a critical threshold, the barrier and
Aurélien Pipparelli, Yvan Arsenijevic, Gilles Thuret, Philippe Gain, Michael Nicolas, François Majo   +5 more
doaj   +1 more source

Start codon disruption with CRISPR/Cas9 prevents murine Fuchs’ endothelial corneal dystrophy

eLife, 2021
A missense mutation of collagen type VIII alpha 2 chain (COL8A2) gene leads to early-onset Fuchs’ endothelial corneal dystrophy (FECD), which progressively impairs vision through the loss of corneal endothelial cells.
Hironori Uehara, Xiaohui Zhang, Felipe Pereira, Siddharth Narendran, Susie Choi, Sai Bhuvanagiri, Jinlu Liu, Sangeetha Ravi Kumar, Austin Bohner, Lara Carroll, Bonnie Archer, Yue Zhang, Wei Liu, Guangping Gao, Jayakrishna Ambati, Albert S Jun, Balamurali K Ambati   +16 more
doaj   +1 more source

Effect of Mitomycin-C augmented trabeculectomy on corneal endothelial cells

Journal of Ophthalmic & Vision Research, 2015
Purpose: To evaluate the effect of mitomycin-C (MMC) on corneal endothelial cell density (ECD) and morphology after trabeculectomy. Methods: In this prospective comparative case series, 31 eyes with glaucoma underwent trabeculectomy with (group I), or ...
Reza Zarei, Mohammad Zarei, Ghasem Fakhraie, Yadollah Eslami, Sasan Moghimi, Masoud Mohammadi, Ali Abdollahi   +6 more
doaj   +1 more source

Corneal thickness and endothelial morphology in Normal Thai eyes

BMC Ophthalmology, 2020
Background This study aimed to determine the influence of age on central corneal thickness and corneal endothelial morphology as well as to identify the relationship between them in normal Thai eyes.
Napaporn Tananuvat, Natawan Khumchoo
doaj   +1 more source

Long-Term Destiny of Corneal Endothelial Cells in Anterior Chamber Intraocular Lens-Implanted Eyes

Journal of Ophthalmology, 2020
Purpose. To investigate the long-term changes of corneal endothelial cells (EC) in anterior chamber intraocular lens- (AC-IOL-) implanted eyes. Methods. Retrospective study.
Yating Tang, Jie Xu, Jiahui Chen, Yi Lu
doaj   +1 more source

Is Pterygium Morphology Related to Loss of Corneal Endothelial Cells? A Cross-Sectional Study

Clinical Ophthalmology, 2021
To determine the difference in mean corneal endothelial cell density (CECD) between the healthy and diseased eyes of the patients with unilateral pterygium with different morphology patterns by using a non-contact specular microscope (SP2000: Topcon Corporation, Japan) and to find out any relationship between severity of pterygium and daily sunlight ...
Syed Bilal Hassan Zaidi, Wajid Ali Khan
openaire   +4 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source