Results 51 to 60 of about 25,735 (191)

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

Corneal Endothelial Cell Loss in Viral Anterior Uveitis

Annals of Optometry and Contact Lens
Viral anterior uveitis is an inflammatory disease caused by pathogens such as herpes simplex virus (HSV), varicella-zoster virus (VZV), and cytomegalovirus (CMV), often leading to corneal endothelial cell damage. Endothelial cell loss progresses due to various factors, including direct viral infection, immune responses, elevated intraocular pressure ...
In Young Chung, Seong-Jae Kim
openaire   +1 more source

Ocular morphology and morphometry of the great egret (Ardea alba): A comprehensive anatomical description

The Anatomical Record, EarlyView.
Abstract Ardea alba (Linnaeus, 1758) is widely distributed, yet knowledge of its ocular morphology remains limited. This study described the morphometry and morphology of the eyeball and its accessory glands in six specimens using radiography, morphometry, light and scanning electron microscopy, and 3D scanning.
Julia Vaz Feio, Max Alex Santos Ferreira, Iara Fernanda Lima do Espírito Santo, Elane Guerreiro Giese, Érika Branco, Antônio Basílio Guerreiro Junior, Ana Rita de Lima   +6 more
wiley   +1 more source

Fuchs endothelial corneal dystrophy: current perspectives

Clinical Ophthalmology, 2016
Gustavo Vedana, Guadalupe Villarreal Jr, Albert S Jun Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA Abstract: Fuchs endothelial corneal dystrophy (FECD) is the most common corneal dystrophy and frequently results in ...
Vedana G, Villarreal Jr G, Jun AS
doaj  

Corneal nerve and endothelial cell damage in patients with transient ischemic attack and minor ischemic stroke.

PLoS ONE, 2019
ObjectiveTo determine if corneal confocal microscopy can identify corneal nerve and endothelial cell abnormalities and may be useful in the prognostication of patients with transient ischemic attack [1] or minor ischemic stroke (IS).MethodsThirty-six ...
Hoda Gad, Adnan Khan, Naveed Akhtar, Saadat Kamran, Ahmed El-Sotouhy, Soha R Dargham, Ioannis N Petropoulos, Georgios Ponirakis, Ashfaq Shuaib, Leopold J Streletz, Rayaz A Malik   +10 more
doaj   +1 more source

Long-term efficacy and safety of ExPress implantation for treatment of open angle glaucoma [PDF]

International Journal of Ophthalmology, 2017
AIM: To compare the long-term efficacy and safety of ExPress implantation and standard trabeculectomy in patients with primary open angle glaucoma (POAG).
Geun Young Lee, Chong Eun Lee, Kyoo Won Lee, Sam Seo   +3 more
doaj   +1 more source

Predicting Endothelial Cell Loss and Long-Term Corneal Graft Survival

Investigative Opthalmology & Visual Science, 2003
To evaluate a biexponential decay model for describing the loss of corneal endothelial cells with age as well as the increased loss of cells after cataract surgery and penetrating keratoplasty.Data from previous studies were identified and the sum of two exponentials, d = p. exp(-at) + q.
Armitage, WJ, Dick, AD, Bourne, WM
openaire   +3 more sources

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Corneal Endothelial Cell Loss in Femtosecond Laser-assisted Descemet's Stripping Automated Endothelial Keratoplasty: A 12-month Follow-up Study

Chinese Medical Journal, 2017
Background: Descemet's stripping automated endothelial keratoplasty (DSAEK) surgery offers a more standardized approach and reliable method to create corneal grafts with an instrument such as a microkeratome.
Yun Feng, Hong-Qiang Qu, Jing Ren, Philipp Prahs, Jing Hong   +4 more
doaj   +1 more source