Results 131 to 140 of about 4,940,025 (211)

Dysregulation of theTCF4Isoform in Corneal Endothelial Cells of Patients With Fuchs Endothelial Corneal Dystrophy

Investigative Ophthalmology & Visual Science
This study evaluated the dysregulation of TCF4 isoforms and differential exon usage (DEU) in corneal endothelial cells (CECs) of Fuchs endothelial corneal dystrophy (FECD) with or without trinucleotide repeat (TNR) expansion in the intron region of the TCF4 gene.Three RNA-Seq datasets of CECs (our own and two other previously published datasets ...
Honda, Tetsuro, Nakagawa, Tatsuya, Yuasa, Taichi, Tokuda, Yuichi, Nakano, Masakazu, Tashiro, Kei, Tourtas, Theofilos, Schlötzer-Schrehardt, Ursula, Kruse, Friedrich, Yamamoto, Koji, Koizumi, Noriko, Okumura, Naoki   +11 more
openaire   +2 more sources

Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells [PDF]

, 2003
Background— Transplantation of ex vivo expanded circulating endothelial progenitor cells (EPCs) from peripheral blood mononuclear cells improves the neovascularization after critical ischemia. However, the origin of the endothelial progenitor lineage and
Dimmeler, S, Heeschen, C, Aicher, A, Urbich, C, Zeiher, AM, Dernbach, E   +5 more
core  

Depth of DNA photodamage in human corneas exposed to 222 nm or 254 nm UV

Photochemistry and Photobiology, EarlyView.
Representative confocal 3D image of a section of a human cornea showing nuclei in blue (Hoechst 33342) and green, which was assigned to cells exhibiting Alexa555 conjugated to anti‐CPD antibody. The depth of photodamage was measured in Z‐stacks of the human corneal epithelium after exposure of the anterior surface to 50 or 100 mJ/cm2 at 222 or 254 nm ...
Manuela Buonanno, Istvan R. Boldogh, Raabia Hashmi, Camryn Petersen, David Welch, Theresa C. Swayne, David J. Brenner   +6 more
wiley   +1 more source

The TCF4 Gene Regulates Apoptosis of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy

Investigative Ophthalmology & Visual Science
Fuchs endothelial corneal dystrophy (FECD) is a progressive corneal disorder characterized by excessive extracellular matrix (ECM) accumulation and corneal endothelial cell death. CTG trinucleotide repeat expansion in the transcription factor 4 (TCF4) gene represents the most significant genetic risk factor.
Nakagawa, Tatsuya, Honda, Tetsuro, Yuasa, Taichi, Nishiuchi, Go, Sato, Masakazu, Tokunaga, Ayumi, Nakahara, Makiko, Tourtas, Theofilos, Schlötzer-Schrehardt, Ursula, Kruse, Friedrich, Padmanabhan, Prema, Chatterjee, Amit, Sathe, Gajanan, Ghose, Vivek, Janakiraman, Narayanan, Blake, Derek J., Koizumi, Noriko, Elchuri, Sailaja, Okumura, Naoki   +18 more
openaire   +2 more sources

The cell-fate decision of dental follicle stem cells (DFSCs) with porcine corneal extracellular matrix (ECM)

Journal of Dental Sciences
Background/purpose: Extracellular matrix (ECM) may be useful as a natural scaffold for tissue engineering. Since dental follicle stem cells (DFSCs) share a similar embryonic origin with corneal keratocytes and endothelial cells and possess the ability to
Kuan-Ming Lin, Yong-Ren Chen, Ming-Hua Ho, Chung-Hsing Li   +3 more
doaj   +1 more source

Challenges of obtaining cultured corneal endothelial cells for regenerative purposes [PDF]

Human posterior corneal epithelium (corneal endothelium) has limited proliferative activity both in vivo and in vitro. Disease or dysfunction in these cells leads to impaired corneal transparency of varying degrees of severity, up to blindness. Currently,
O. P. Antonova, S. A. Borzenok, T. Z. Kerimov, D. S. Ostrovski, B. E. Malyugin, M. Kh. Khubetsova   +5 more
core   +1 more source

Human ocular‐discomfort‐free thresholds for 222 nm Far‐UVC irradiation: A prospective interventional study

Photochemistry and Photobiology, EarlyView.
Eye discomfort induced by 222 nm far‐UVC irradiation is significantly correlated with both irradiance and radiant exposure dose. The red circles indicate conditions with significant differences in the number of eye discomfort compared to the control group (blue circles), while the green circles indicate conditions with no difference from the control ...
Sachiko Kaidzu, Kazunobu Sugihara, Masaki Tanito   +2 more
wiley   +1 more source

Early oxidation‐related changes in aqueous humor following eye exposure to ultraviolet‐A radiation

Photochemistry and Photobiology, EarlyView.
UVA exposure induces early oxidative alterations in the aqueous humor, disrupting its antioxidant balance. Levels of ascorbic acid, reduced glutathione (GSH), and the GSH/GSSG ratio decrease, while oxidized glutathione (GSSG), S‐glutathionylated proteins (PSSG), and malondialdehyde (MDA), a lipid peroxidation by‐product, increase.
Corinne Zinflou, Patrick J. Rochette
wiley   +1 more source

Central corneal thickness and corneal endothelial characteristics in healthy, cataract, and glaucoma patients

, 2012
Saulius Galgauskas, Dalia Krasauskaite, Mykolas Pajaujis, Grazina Juodkaite, Rimvydas-Stanislovas AsoklisVilnius University Faculty of Medicine, ENT and Eye Clinic, Vilnius, LithuaniaPurpose: The aim of this study was to describe and compare endothelial ...
Asoklis RS, Juodkaite G, Galgauskas S, Pajaujis M, Krasauskaite D   +4 more
core  

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source