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Injectable corneal endothelial cell therapy: recent progress, translational barriers, and future directions [PDF]

Frontiers in Ophthalmology
IntroductionCorneal endothelial dysfunction, most commonly caused by Fuchs endothelial corneal dystrophy (FECD) or pseudophakic bullous keratopathy (PBK), leads to stromal edema and corneal decompensation when endothelial cell density (ECD) falls below ...
Ghadeer Mohammed, Muhammad Abbas Tayyab, Jaffer Hussain, Renad AlDhib, Mifrah Rahat Khan Sherwani, Johar Abbas, Zahra Arsalan, Carolina Mercado   +7 more
doaj   +2 more sources

Efficient Generation of Human Embryonic Stem Cell-Derived Corneal Endothelial Cells by Directed Differentiation. [PDF]

PLoS ONE, 2015
AIM:To generate human embryonic stem cell derived corneal endothelial cells (hESC-CECs) for transplantation in patients with corneal endothelial dystrophies.
Kathryn L McCabe, Noelia J Kunzevitzky, Brian P Chiswell, Xin Xia, Jeffrey L Goldberg, Robert Lanza   +5 more
doaj   +3 more sources

Changes in corneal endothelial cell loss in different regions in patients with cataracts and peripheral anterior synechiae after phacoemulsification combined with goniosynechialysis [PDF]

Frontiers in Medicine
PureposeTo evaluated regional changes in regional corneal endothelial cell density and morphology during the first month after phacoemulsification with intraocular lens implantation combined with goniosynechialysis (PEI+GSL) in cataract eyes with ...
Dan Huang, Dan Huang, Tingting Zhu, Tingting Zhu, Xiangying Luo, Xiangying Luo, Ting Xi, Ting Xi, Zhenxing Liu, Zhenxing Liu   +9 more
doaj   +2 more sources

Deferoxamine Modulates Corneal Endothelial Cell Biological Properties Associated with Increased VEGF Expression [PDF]

Medicina
Background and Objectives: The objective of this study is to evaluate whether deferoxamine modulates cell biological properties, such as proliferation and wound closure of porcine corneal endothelial cells (CECs) in vitro, and whether the treatment of ...
Barbara Sophie Brunner, Paul Emesz, Nikolaus Luft, Siegfried Georg Priglinger, Andreas Ohlmann, Stefan Kassumeh   +5 more
doaj   +2 more sources

Association of corneal endothelial cell morphology with neurodegeneration in mild cognitive impairment and dementia [PDF]

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION Corneal confocal microscopy (CCM) detects neurodegeneration in mild cognitive impairment (MCI) and dementia and identifies subjects with MCI who develop dementia.
Georgios Ponirakis, Hanadi Al Hamad, Alaa S. Al‐Waisy, Ioannis N. Petropoulos, Adnan Khan, Hoda Gad, Mani Chandran, Masharig Gadelseed, Salah Mahmoud, Ahmed Elsotouhy, Marwan Ramadan, Shafi Khan, Rustu E. Akcan, Priya V. Gawhale, Noushad Thodi, Tala Nakouzi, Moayad Homssi, Nebras Hadid, Aisha Al Obaidan, Rawan Hussein, Ahmed Own, Ashfaq Shuaib, Rayaz A. Malik   +22 more
doaj   +2 more sources

Relationship Between Postoperative Oxidative Stress Levels and Corneal Endothelial Cell Loss After Phacoemulsification in Diabetic Patients with Cataract [PDF]

Clinical Ophthalmology
Yuan Gao,* Ning Yang,* LiJuan Wei, YiJie Yan, Lei Li Department of Ophthalmology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou City, Hainan Province, 570311, People’s Republic of China*These ...
Gao Y, Yang N, Wei L, Yan Y, Li L
doaj   +2 more sources

Evaluation of Corneal Endothelium Function by Combined Measurement of Corneal Volume and Specular Microscopy before and after Phacoemulsification [PDF]

Al-Azhar International Medical Journal, 2020
Background: Clarity of the cornea is fundamental for pure vision following cataract surgery including phacoemulsification . The pumping action of corneal endothelial cells acts to maintain this clarity through maintaining the corneal stroma dehydrated ...
omar salama, Abdallah Elhusseiny, Mohammed mohammed el werdany   +2 more
doaj   +1 more source

Long-term observation after transplantation of cultured human corneal endothelial cells for corneal endothelial dysfunction

Stem Cell Research & Therapy, 2022
Background Corneal transplantation is the only way to treat serious corneal diseases caused by corneal endothelial dysfunction. However, the shortage of donor corneal tissues and human corneal endothelial cells (HCECs) remains a worldwide challenge.
Peng Sun, Lin Shen, Yuan-Bin Li, Li-Qun Du, Xin-Yi Wu   +4 more
doaj   +1 more source

Rate of Cornea Endothelial Cell Loss and Biomechanical Properties in Fuchs' Endothelial Corneal Dystrophy

Frontiers in Medicine, 2021
Background: Our study aimed to determine the correlation between the clinical staging of Fuchs' endothelial corneal dystrophy (FECD), rate of endothelial cell loss, and corneal biomechanical properties.Methods: This study combined a longitudinal ...
Usanee Reinprayoon, Usanee Reinprayoon, Monthira Jermjutitham, Ngamjit Kasetsuwan, Ngamjit Kasetsuwan   +4 more
doaj   +1 more source

Telomerase immortalization of human corneal endothelial cells yields functional hexagonal monolayers. [PDF]

PLoS ONE, 2012
Human corneal endothelial cells (HCEnCs) form a monolayer of hexagonal cells whose main function is to maintain corneal clarity by regulating corneal hydration. HCEnCs are derived from neural crest and are arrested in the post-mitotic state.
Thore Schmedt, Yuming Chen, Tracy T Nguyen, Shimin Li, Joseph A Bonanno, Ula V Jurkunas   +5 more
doaj   +1 more source