New Horizons in the Treatment of Corneal Endothelial Dysfunction [PDF]
Journal of Ophthalmology, 2021 The treatment of corneal endothelial dysfunction has experienced a revolutionary change in the past decades with the emergence of endothelial keratoplasty techniques: descemet stripping automated endothelial keratoplasty (DSAEK) and descemet membrane ...
Carlos Rocha-de-Lossada +9 more
doaj +12 more sources
Long-Term Observation and Sequencing Analysis of SKPs-Derived Corneal Endothelial Cell-Like Cells for Treating Corneal Endothelial Dysfunction [PDF]
Cell Transplantation, 2021 Corneal endothelial dysfunction is a principal cause of visual deficiency. Corneal transplantation is the most effective treatment for corneal endothelial dysfunction.
Lin Shen, Xinyi Wu, Liqun Du
exaly +6 more sources
Sleep deprivation induces corneal endothelial dysfunction by downregulating Bmal1 [PDF]
BMC OphthalmologyBackground Sleep deprivation (SD) is a common public health problem that contributes to various physiological disorders and increases the risk of ocular diseases. However, whether sleep loss can damage corneal endothelial function remains unclear.
Yani Wang +4 more
doaj +5 more sources
Safety and efficacy of human ESC-derived corneal endothelial cells for corneal endothelial dysfunction [PDF]
Cell & Bioscience, 2023 Background Research on human pluripotent stem cells (hPSCs) has shown tremendous progress in cell-based regenerative medicine. Corneal endothelial dysfunction is associated with the loss and degeneration of corneal endothelial cells (CECs), rendering ...
Juan Yu +13 more
doaj +4 more sources
Long-term observation after transplantation of cultured human corneal endothelial cells for corneal endothelial dysfunction [PDF]
Stem Cell Research & Therapy, 2022 Background Corneal transplantation is the only way to treat serious corneal diseases caused by corneal endothelial dysfunction. However, the shortage of donor corneal tissues and human corneal endothelial cells (HCECs) remains a worldwide challenge.
Peng Sun +4 more
doaj +5 more sources
Corneal Endothelial Cell Dysfunction: Etiologies and Management [PDF]
Therapeutic Advances in Ophthalmology, 2018 A transparent cornea is essential for the formation of a clear image on the retina. The human cornea is arranged into well-organized layers, and each layer plays a significant role in maintaining the transparency and viability of the tissue.
Sepehr Feizi
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Therapeutic Potential of Rho-Associated Kinase Inhibitor Y27632 in Corneal Endothelial Dysfunction: An in Vitro and in Vivo Study. [PDF]
International Journal of Ophthalmology, 2021 AIM: To investigate the effects of a selective inhibitor of Rho-associated kinase (ROCK), Y-27632, on inbred Wuzhishan porcine corneal endothelial cells (PCECs) in vitro and in vivo studies.
Yao-Wen Song +4 more
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Pathogenic Role of Endoplasmic Reticulum Stress in Diabetic Corneal Endothelial Dysfunction [PDF]
Investigative Ophthalmology and Visual Science, 2022 Progressive corneal edema and endothelial cell loss represent the major corneal complications observed in diabetic patients after intraocular surgery. However, the underlying pathogenesis and potential treatment remain incompletely understood.We used streptozotocin-induced type 1 diabetic mice and db/db type 2 diabetic mice as diabetic animal models ...
Lixin Xie, Mingli Qu, Huifeng Wang
exaly +4 more sources
Ex vivo cultivated retinal pigment epithelial cell transplantation for the treatment of rabbit corneal endothelial dysfunction [PDF]
Eye and Vision, 2023 Objective Stem cell therapy is a promising strategy for the treatment of corneal endothelial dysfunction, and the need to find functional alternative seed cells of corneal endothelial cells (CECs) is urgent.
Chunxiao Dong +6 more
doaj +2 more sources
A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts [PDF]
Advanced ScienceCorneal endothelial dysfunction is a major cause of global blindness, with an estimated 12.7 million patients awaiting corneal transplantation, and the severe shortage of donor grafts underscores the urgent need for non‐surgical therapies.
Hongran Zhao +10 more
doaj +2 more sources