Results 21 to 30 of about 959,050 (193)

Bone Marrow-Derived Endothelial Progenitor Cells: A Promising Therapeutic Alternative for Corneal Endothelial Dysfunction

Cells Tissues Organs, 2010
<i>Background:</i> The global shortage of donor corneas has motivated the development of bioengineered corneas. Although corneal endothelium has been reconstituted using corneal endothelial cells (CEC) and precursor cells with various carrier
Yao Fu, Chunyi Shao, Wenjuan Lu, Xianqun Fan   +3 more
core   +3 more sources

PEDF Prevents Corneal Endothelial Dysfunction of Fuchs Endothelial Corneal Dystrophy. [PDF]

Invest Ophthalmol Vis Sci
The purpose of this study was to explore the protection of pigment epithelium-derived factor (PEDF) on the corneal endothelium in Fuchs endothelial corneal dystrophy (FECD).PEDF levels in aqueous humor of FECD patients were quantified by enzyme-linked immunosorbent assay.
Yao S, Qiao Y, Lin Y, Sui X, Zhou Q, Wang T, Wang Q, Zhao C.   +7 more
europepmc   +4 more sources

Therapeutic Potency of Induced Pluripotent Stem-Cell-Derived Corneal Endothelial-like Cells for Corneal Endothelial Dysfunction. [PDF]

Int J Mol Sci, 2022
Corneal endothelial cells (CECs) do not proliferate or recover after illness or injury, resulting in decreased cell density and loss of pump/barrier function. Considering the shortage of donor cornea, it is vital to establish robust methods to generate CECs from induced pluripotent stem cells (iPSCs).
So S, Park Y, Kang SS, Han J, Sunwoo JH, Lee W, Kim J, Ye EA, Kim JY, Tchah H, Kang E, Lee H.   +11 more
europepmc   +3 more sources

ATF4 regulates mitochondrial dysfunction and mitophagy, contributing to corneal endothelial apoptosis

Scientific Reports
Endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and mitophagy are known to contribute independently to corneal endothelial cell (CEnC) apoptosis in Fuchs’ endothelial corneal dystrophy (FECD).
Saba Qureshi, Stefan Y. Kim, Stephanie Lee, Lukas Ritzer, William Steidl, Gayle Joliet Krest, Anisha Kasi, Varun Kumar   +7 more
doaj   +3 more sources

Visual Outcomes following Descemet Stripping Automated Endothelial Keratoplasty for Corneal Endothelial Dysfunction

European Journal of Ophthalmology, 2017
Objective To assess objective and subjective visual outcomes achieved by patients with corneal endothelial dysfunction who have undergone surgical treatment with Descemet stripping automated endothelial keratoplasty (DSAEK). Methods A total of 40 eyes of
Christophe Goetz, Nadia Ouamara, Oualid Guechi, Naila Houmad, Jean Marc Perone, Louis Lhuillier   +5 more
core   +3 more sources

Long-Term Persistent Exposure to Cigarette Smoke Induces AhR Driven Corneal Endothelial Dysfunction in Mice [PDF]

Experimental Eye Research
Yohannes Tesfaigzi, Ula V Jurkunas, Mohit Parekh   +2 more
exaly   +2 more sources

A Rabbit Corneal Endothelial Dysfunction Model Using Endothelial-Mesenchymal Transformed Cells. [PDF]

Sci Rep, 2018
Abstract Unlike humans, rabbit corneal endothelial wounds are known to spontaneously heal. The current study was aimed to develop a new rabbit bullous keratopathy model using corneal endothelial cells that were induced to undergo endothelial-mesenchymal transformation (EMT).
Yamashita K, Hatou S, Inagaki E, Higa K, Tsubota K, Shimmura S.   +5 more
europepmc   +4 more sources

Effects of Aberrant Pax6 Gene Dosage on Mouse Corneal Pathophysiology and Corneal Epithelial Homeostasis [PDF]

, 2011
Background: Altered dosage of the transcription factor PAX6 causes multiple human eye pathophysiologies. PAX6(+/-) heterozygotes suffer from aniridia and aniridia-related keratopathy (ARK), a corneal deterioration that probably involves a limbal ...
Mort, Richard L., Fullwood, Nigel J., West, John D., Martin, Francis L., Collinson, J. Martin, Morley, Steven D., Douvaras, Panagiotis, Hill, Robert E., Bentley, Adam J.   +8 more
core   +5 more sources

Additional file 2 of Long-term observation after transplantation of cultured human corneal endothelial cells for corneal endothelial dysfunction

, 2022
Additional file 2: Figure S2. Clinical observation of the control group and the TR2Y group after transplantation of CM-HCECs. Slit-lamp photographs show the monkey corneal endothelial dysfunction model in the control group (left).
Xin-Yi Wu (1964719), Peng Sun (112156), Yuan-Bin Li (12792994), Li-Qun Du (12792997), Lin Shen (507259)   +4 more
core   +1 more source

Bioinformatic Analysis of the Value of Mitophagy and Immune Responses in Corneal Endothelial Dysfunction. [PDF]

Curr Issues Mol Biol
This study was conducted to elucidate the mitophagy-related differentially expressed genes (MRDEGs) in corneal endothelial dysfunction (CED) and to identify key hub genes that could provide insights into the disease pathogenesis and potential targeted therapies.
Guo R, Xu C, Yu Y, Ma M, Dong X, Wu J, Ouyang C, Ling J, Huang T.   +8 more
europepmc   +3 more sources