Mitochondrial Dysfunction and Mitophagy in Fuchs Endothelial Corneal Dystrophy [PDF]
Cells, 2021 Fuchs endothelial corneal dystrophy (FECD) is a genetically complex, heterogenous, age-related degenerative disease of corneal endothelial cells (CEnCs), occurring in the fifth decade of life with a higher incidence in females.
Varun Kumar, Ula V. Jurkunas
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Corneal endothelial dysfunction: etiology, pathogenesis, and current treatment approaches [PDF]
Клиническая офтальмология, 2019 The article reviews current approaches to the treatment of corneal endothelium dysfunction. The most common causes of endothelial decompensation are Fuchs’ corneal dystrophy and secondary bullous keratopathy.
S.V. Trufanov, E.P. Salovarova
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Animal models of corneal endothelial dysfunction to facilitate development of novel therapies. [PDF]
Ann Transl Med, 2021 Progressive corneal endothelial disease eventually leads to corneal edema and vision loss due to the limited regenerative capacity of the corneal endothelium in vivo and is a major indication for corneal transplantation.
Park S +7 more
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Corneal Endothelial Dysfunction Caused by Asclepias curassavica in a Young Farmer [PDF]
American Journal of Ophthalmology Case Reports, 2019 To introduce a case of corneal endothelial toxicity caused by Asclepias curassavica (Milkweed) in Korea.A 37-year-old Asian man presented with decreased vision and redness in the right eye, which developed after contact with Asclepias curassavica. At presentation, best-corrected visual acuity (BCVA) was 20/60 in the right eye.
Sang Beom Han, Joon Young Hyon
exaly +5 more sources
Therapy of corneal endothelial dysfunction with corneal endothelial cell-like cells derived from skin-derived precursors [PDF]
Scientific Reports, 2017 Corneal endothelial dysfunction occurs when corneal endothelial cells (CECs) are dramatically lost and eventually results in vision loss. Corneal transplantation is the only solution at present.
Xinyi Wu +5 more
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Generation and Feasibility Assessment of a New Vehicle for Cell-Based Therapy for Treating Corneal Endothelial Dysfunction. [PDF]
PLoS ONE, 2016 The corneal endothelium maintains corneal transparency by its pump and barrier functions; consequently, its decompensation due to any pathological reason causes severe vision loss due to corneal haziness.
Naoki Okumura +8 more
doaj +2 more sources
Journal of Biomedical Science, 2019 Human corneal endothelial cells are notorious for their restricted proliferative ability in vivo and in vitro. Hence, injury or dysfunction of these cells may easily result in blindness.
Shuangling Chen +6 more
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Extracellular Vesicles Derived From Human Corneal Endothelial Cells Inhibit Proliferation of Human Corneal Endothelial Cells [PDF]
Frontiers in Medicine, 2022 Corneal endothelial cells (CEnCs) are a monolayer of hexagonal cells that are responsible for maintaining the function and transparency of the cornea. Damage or dysfunction of CEnCs could lead to blindness.
Mohit Parekh +5 more
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Challenges of obtaining cultured corneal endothelial cells for regenerative purposes [PDF]
Вестник трансплантологии и искусственных органовHuman posterior corneal epithelium (corneal endothelium) has limited proliferative activity both in vivo and in vitro. Disease or dysfunction in these cells leads to impaired corneal transparency of varying degrees of severity, up to blindness. Currently,
D. S. Ostrovski +5 more
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Outcomes of Descemet stripping endothelial keratoplasty in cases of corneal endothelial dysfunction. [PDF]
Oman J Ophthalmol, 2022 BACKGROUND: Automated microkeratome is commonly used to get donor lenticules for Descemet stripping endothelial keratoplasty (DSEK); however, manual dissection of donor lenticules is also being done with good outcomes.
Srujana D, Bista N, Agrawal M.
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