Results 31 to 40 of about 959,050 (193)
The Journal of Clinical Investigation, 2022 Human pluripotent stem cells (hPSCs) hold great promise for the treatment of various human diseases. However, their therapeutic benefits and mechanisms for treating corneal endothelial dysfunction remain undefined.
Zongyi Li +15 more
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Influence of hyperhomocysteinemia on the cellular redox state - Impact on homocysteine-induced endothelial dysfunction [PDF]
, 2003 Hyperhomocysteinemia is an independent risk factor for the development of atherosclerosis. An increasing body of evidence has implicated oxidative stress as being contributory to homocysteines deleterious effects on the vasculature.
Keaney, John F. +5 more
core +1 more source
Human Bone Derived Collagen for the Development of an Artificial Corneal Endothelial Graft. In Vivo Results in a Rabbit Model. [PDF]
PLoS ONE, 2016 Corneal keratoplasty (penetrating or lamellar) using cadaveric human tissue, is nowadays the main treatment for corneal endotelial dysfunctions. However, there is a worldwide shortage of donor corneas available for transplantation and about 53% of the ...
Natalia Vázquez +9 more
doaj +1 more source
Atrial Natriuretic Peptide Protects against Histamine-Induced Endothelial Barrier Dysfunction in Vivo [PDF]
, 2008 Endothelial barrier dysfunction is a hallmark of many severe pathologies, including sepsis or atherosclerosis. The cardiovascular hormone atrial natriuretic peptide (ANP) has increasingly been suggested to counteract endothelial leakage.
Mayer, Bettina A. +9 more
core +1 more source
Frontiers in Endocrinology, 2021 Diabetic polyneuropathy (DPN) and endothelial dysfunction are prevalent complications of diabetes mellitus. Currently, there are two non-invasive markers for endothelial dysfunction: flow-mediated dilation and reactive hyperaemia peripheral arterial ...
Akihiko Ando +10 more
doaj +1 more source
Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase [PDF]
, 2009 Proline-rich tyrosine kinase 2 (PYK2) can be activated by angiotensin II (Ang II) and reactive oxygen species. We report that in endothelial cells, Ang II enhances the tyrosine phosphorylation of endothelial NO synthase (eNOS) in an AT1-, H2O2-, and PYK2-
Loot, Annemarieke E. +7 more
core +1 more source
RESTORATION OF CORNEA ENDOTHELIUM FUNCTION (REVIEW)
Сибирский научный медицинский журнал, 2019 Review highlights modern findings on molecular mechanisms of dysfunction of human corneal endothelial cells causes decline of vision. When water enters the corneal stroma, it disorganizes the regular arrangement of the collagen fibrils, which reduces ...
G. S. Baturina +3 more
doaj +1 more source
Biomaterials for corneal endothelial cell culture and tissue engineering
Journal of Tissue Engineering, 2021 The corneal endothelium is the posterior monolayer of cells that are responsible for maintaining overall transparency of the avascular corneal tissue via pump function.
Mohit Parekh +14 more
doaj +1 more source
Cell Transplantation, 2016 The corneal endothelium plays a primary role in maintaining corneal homeostasis and clarity and must be surgically replaced with allogenic donor corneal endothelium in the event of visually significant dysfunction.
Ricardo F. Frausto +2 more
doaj +1 more source
Evaluation of Corneal Endothelium Function by Combined Measurement of Corneal Volume and Specular Microscopy before and after Phacoemulsification [PDF]
Al-Azhar International Medical Journal, 2020 Background: Clarity of the cornea is fundamental for pure vision following cataract surgery including phacoemulsification . The pumping action of corneal endothelial cells acts to maintain this clarity through maintaining the corneal stroma dehydrated ...
omar salama +2 more
doaj +1 more source