Results 121 to 130 of about 315,440 (342)

Regulation of Oxidative Stress in Corneal Endothelial Cells by Prdx6

Antioxidants, 2018
The inner layer of the cornea, the corneal endothelium, is post-mitotic and unable to regenerate if damaged. The corneal endothelium is one of the most transplanted tissues in the body.
Matthew Lovatt, Khadijah Adnan, Gary S. L. Peh, Jodhbir S. Mehta   +3 more
doaj   +1 more source

Identification of Therapeutic Targets of Inflammatory Monocyte Recruitment to Modulate the Allogeneic Injury to Donor Cornea [PDF]

, 2015
Purpose: We sought to test the hypothesis that monocytes contribute to the immunopathogenesis of corneal allograft rejection and identify therapeutic targets to inhibit monocyte recruitment.
Becker, DL, Chain, BM, Haas, CT, Lapp, T, Larkin, DFP, Noursadeghi, M, Thrasivoulou, C, Zaher, SS   +7 more
core   +1 more source

Dynamic Retinal Pathology in Glaucoma Progression Revealed by High‐Resolution Functional Imaging in Vivo

Laser &Photonics Reviews, EarlyView.
In this work, we investigated the dynamic retinal pathology of glaucoma from onset to late stages through longitudinal in vivo high‐resolution imaging in a silicone oil‐induced ocular hypertension (SOHU) glaucoma mouse model. We developed an optimized adaptive optics two‐photon excitation fluorescence microscopy (AO‐TPEFM) technique for morphological ...
Yiming Fu, Pham Binh Minh, Sicong He, Yingzhu He, Zhongya Qin, Ting Xie, Jianan Qu   +6 more
wiley   +1 more source

Transcriptomic Analysis of Cultured Corneal Endothelial Cells as a Validation for Their Use in Cell Replacement Therapy

Cell Transplantation, 2016
The corneal endothelium plays a primary role in maintaining corneal homeostasis and clarity and must be surgically replaced with allogenic donor corneal endothelium in the event of visually significant dysfunction.
Ricardo F. Frausto, Derek J. Le, Anthony J. Aldave M.D.   +2 more
doaj   +1 more source

Refractive change following pseudophakic vitrectomy: a retrospective review [PDF]

, 2008
Background To assess the occurrence and magnitude of refractive change in pseudophakic eyes undergoing 20 gauge pars plana vitrectomy without scleral buckling and to investigate possible aetiological factors.
Anthony Hildreth, CY Hu, David HW Steel, James Ng, JB Randleman, Jean-Pierre Danjoux, JR McEwan, JW Jeoung, L Zheng, M Shioya, O Cekic, O Findl, P Brazitikos, RV Campo, S Cisiecki, Sinead Byrne, T Eckert, T Oshika, Y Suzuki, YR Sharma   +19 more
core   +5 more sources

Repressed miR-34a Expression Dictates the Cell Fate to Corneal Endothelium Failure

, 2022
Junji Hamuro, Kazuko Asada, Morio Ueno, Tomoko Yamashita, Atsushi Mukai, Tomoko Fujita, Eiko Ito, Nobuhiro Hiramoto, Munetoyo Toda, Chie Sotozono, Shigeru Kinoshita   +10 more
openalex   +1 more source

AP-2β Is a Downstream Effector of PITX2 Required to Specify Endothelium and Establish Angiogenic Privilege During Corneal Development

Investigative Ophthalmology and Visual Science, 2016
Purpose The homeodomain transcription factor, PITX2, is at the apex of a genetic pathway required for corneal development, but the critical effector genes regulated by the PITX2 remain unknown. The purpose of this study was to discover and validate PITX2-
Lisheng Chen, Vanessa B Martino, Alan A. Dombkowski, T. Williams, J. West-Mays, P. Gage   +5 more
semanticscholar   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Effects of atracurium besylate on corneal endothelium of chickens: in vitro study

Pesquisa Veterinária Brasileira
: The aim of this study was to investigate the acute effects of atracurium besylate on cellular damage in corneal endothelium of chickens. Twenty healthy chicken eyes were assigned to the following groups: Group 1 (G1), experimental group (n=10); and ...
Celeste B. Guimarães, Luciane Albuquerque, Marcela Torikachvili, Eduarda V. Vargas, Cecilia C. Dall’Agnol, Tanise C. Silva, João A.T. Pigatto   +6 more
doaj   +1 more source

Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells [PDF]

, 2008
Purinergic signalling is important both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling.
Burnstock, G
core