mRNA-Based Nanomedicinal Products to Address Corneal Inflammation by Interleukin-10 Supplementation [PDF]
Pharmaceutics, 2021 The anti-inflammatory cytokine Interleukin-10 (IL-10) is considered an efficient treatment for corneal inflammation, in spite of its short half-life and poor eye bioavailability. In the present work, mRNA-based nanomedicinal products based on solid lipid
Mónica Vicente Pascual +2 more
exaly +4 more sources
Topical phenylbutyrate antagonizes NF-κB signaling and resolves corneal inflammation [PDF]
iScience, 2022 Summary: Chronic inflammation of the immune privileged cornea originating from viral or nonviral conditions results in significant vision loss. Topical corticosteroids are the common treatments for corneal inflammation, but the drugs cause serious and ...
Raghuram Koganti +5 more
doaj +3 more sources
Topical Administration of SLN-Based Gene Therapy for the Treatment of Corneal Inflammation by De Novo IL-10 Production [PDF]
Pharmaceutics, 2020 One of the main challenges in gene therapy is the issue of delivery, and it is especially relevant for the success of gene therapy in the cornea. In the present work, eye drops containing biocompatible non-viral vectors based on solid lipid nanoparticles
Mónica Vicente Pascual +2 more
exaly +4 more sources
Resolvin D1 alleviates lipopolysaccharide-induced in vitro corneal inflammation by modulating macrophage polarization through upregulation of c-Fos expression [PDF]
BioImpactsIntroduction: Bacterial keratitis refers to a prevalent sight-threatening ophthalmologic infection. Owing to the challenge of antimicrobial resistance in treating bacterial keratitis, novel therapeutic strategies are needed.
Qin Qin +8 more
doaj +2 more sources
Mechanical activation of PIEZO1 drives AP-1–dependent PTGS2/PGE2 signaling and corneal inflammation [PDF]
iScienceSummary: Abnormal mechanical stimulation, such as eye rubbing, is a critical risk factor for corneal diseases, yet the molecular mechanisms linking mechanical stimulation to inflammation remain unclear.
Zongzheng Zou +10 more
doaj +2 more sources
Allergology International, 2010 : Background: Atopic and vernal keratoconjunctivitis are severe types of ocular allergic disease characterized not only by conjunctival inflammation but also by corneal involvement.
Ken Fukuda, Naoyuki Yamada
exaly +3 more sources
Irradiated umbilical cord mesenchymal stem cell-coated high oxygen-permeable hydrogel lenses inhibit corneal inflammation and neovascularization after corneal alkali burns [PDF]
Scientific ReportsCorneal alkali burns can cause persistent inflammation and corneal neovascularization. In this study, we divided corneal alkali burned rabbits into the untreated group, the blank lens group, the radiation-treated umbilical cord mesenchymal stem cells ...
Siqi Song +9 more
doaj +2 more sources
Pro-inflammatory role of NLRP3 inflammasome in experimental sterile corneal inflammation [PDF]
Scientific Reports, 2019 We evaluated the role of NLR family pyrin domain containing 3 (NLRP3) inflammasome in sterile corneal inflammation caused by lipopolysaccharide (LPS) or alkali burns in C57BL6 mice or NLRP3 KO (Nlrp3 −/− ) mice.
Hiroaki Shimizu +2 more
doaj +2 more sources
Frontiers in Pharmacology, 2022 Corneal neovascularization (CNV) is a sight-threatening condition usually associated with various inflammatory settings including chemical injury. High mobility group box 1 (HMGB1) is identified as an inflammatory alarmin in diverse tissue damage.
Peihong Wang +27 more
doaj +1 more source
Zeb1 regulation of wound-healing-induced inflammation in alkali-damaged corneas
iScience, 2022 Summary: The cornea is an avascular tissue for vision clarity. Alkali burn could cause severe traumatic damage on the cornea with inflammation and neovascularization (NV), leading to vision reduction and blindness.
Wei Liang +9 more
doaj +1 more source