Results 21 to 30 of about 802,092 (249)

Topical rosiglitazone is an effective anti-scarring agent in the cornea [PDF]

, 2013
Corneal scarring remains a major cause of blindness world-wide, with limited treatment options, all of which have side-effects. Here, we tested the hypothesis that topical application of Rosiglitazone, a Thiazolidinedione and ligand of peroxisome ...
Phipps, Richard P., Holly B Hindman, MacRae, Scott, Patricia J Sime, Krystel R Huxlin, David Ciufo, Jeon, Kye-Im, Richard P Phipps, Sime, Patricia J., DeMagistris, Margaret, Ciufo, David, Huxlin, Krystel R., Jens Bühren, Scott MacRae, Kye-Im Jeon, Margaret DeMagistris, Bühren, Jens, Hindman, Holly B.   +17 more
core   +2 more sources

Sectoral, tongue-shaped inflammatory posterior corneal stromal debris with adjacent scleritis and episcleritis of infectious etiologies

Indian Journal of Ophthalmology. Case Reports, 2023
We report an interesting corneal finding of sectoral, tongue-shaped posterior corneal stromal debris with adjacent episcleral inflammation in one case and scleral inflammation in the other case.
Kalpana Babu, Kavya Nagaraj, Vinaya Kumar Konana   +2 more
doaj   +1 more source

MMP-9 Downregulation with Lipid Nanoparticles for Inhibiting Corneal Neovascularization by Gene Silencing

Nanomaterials, 2019
Gene silencing targeting proangiogenic factors have been shown to be a useful strategy in the treatment of corneal neovascularization (CNV). Among interference RNA (RNAi) molecules, short-hairpin RNA (shRNA) is a plasmid-coded RNA able to down-regulate ...
Josune Torrecilla, Itziar Gómez-Aguado, Mónica Vicente-Pascual, Ana del Pozo-Rodríguez, María Ángeles Solinís, Alicia Rodríguez-Gascón   +5 more
doaj   +1 more source

Inhibiting corneal neovascularization by sustainably releasing anti-VEGF and anti-inflammation drugs from silica-thermogel nanohybrids

, 2021
Corneal neovascularization (CNV) is one of the main factors that induce blindness worldwide. To effectively inhibit CNV, a novel nanohybrid has been developed by incorporating anti-VEGF bevacizumab (BEV)-loaded mesoporous silica nanoparticles (BEV@MSN ...
Ning Lyu, Chang Huang, Xu, ZP, Xinghuai Sun, Fan, X, Jun Xiang, Sun, J, Xiangyu Fan, Huang, C, Xiang, J, Xu, J, Yujin Zhao, Zhi Ping Xu, Zhao, Y, Lyu, N, Sun, X, Jianguo Sun, Jianjiang Xu   +17 more
core   +1 more source

TREM-1 expression in rat corneal epithelium with Aspergillus fumigatus infection [PDF]

International Journal of Ophthalmology, 2015
AIM: To investigate the expression of triggering receptor expressed on myeloid cells-1 (TREM-1) in the aberrant inflammation within the corneal epithelium at early period of fungal infection. METHODS: A total of 65 Wistar rats were randomly divided into
Li-Ting Hu, Zhao-Dong Du, Gui-Qiu Zhao, Sheng Qiu, Nan Jiang, Jing Lin, Qian Wang, Qiang Xu   +7 more
doaj   +1 more source

Anti-angiogenic and anti-inflammatory effects of SERPINA3K on corneal injury. [PDF]

PLoS ONE, 2011
SERPINA3K is a member of the serine proteinase inhibitor (SERPIN) family. Here we evaluated the therapeutic effects of SERPINA3K on neovascularization and inflammation in a rat cornea alkali burn model that is commonly employed to study corneal wounding.
Xiaochen Liu, Zhirong Lin, Tong Zhou, Ronrong Zong, Hui He, Zhen Liu, Jian-xing Ma, Zuguo Liu, Yueping Zhou   +8 more
doaj   +1 more source

E3 ligase RNF5 inhibits type I interferon response in herpes simplex virus keratitis through the STING/IRF3 signaling pathway

Frontiers in Microbiology, 2022
Herpes simplex keratitis (HSK), caused by the herpes simplex virus 1 (HSV-1), is a major blinding disease in developed countries. HSV-1 can remain latent in the host for life and cannot be eradicated.
Zhi Liu, Likun Xia
doaj   +1 more source

Evaluation of interface quality in organ-cultured lamellar corneal transplants [PDF]

, 2012
Background: With increasing numbers of lamellar keratoplasties, eye banks are challenged to deliver precut lamellar donor tissue. In Europe, the most common technique of corneal storage is organ culture which requires a deswelling process before surgical
Kohnen, Thomas, Wolf, Armin, Kook, Daniel, Grüterich, Martin, Jagow, Burkhard von, Kampik, Anselm, Lackerbauer, Carlo A., Messmer, Elisabeth M.   +7 more
core   +1 more source

Innate Immune System Activation, Inflammation and Corneal Wound Healing

, 2022
Corneal wounds resulting from injury, surgeries, or other intrusions not only cause pain, but also can predispose an individual to infection. While some inflammation may be beneficial to protect against microbial infection of wounds, the inflammatory ...
Sarah H. Sutton, Mitchell A. Watsky, Wendy B. Bollag, Fortingo, Nyemkuna, Sutton, Sarah H., Samuel Melnyk, Nyemkuna Fortingo, Melnyk, Samuel, Bollag, Wendy B., Watsky, Mitchell A.   +9 more
core   +1 more source

Effect of tear deficiency on the course of endotoxin-induced keratitis

Journal of Ophthalmology, 2015
Background:In recent years, the problem of tear production disorders and dry eye syndrome (DES) has become increasingly important because of significant worldwide prevalence of DES.
T.B. Gaydamaka, S.Ya. Rafalyuk
doaj   +1 more source